山东大学耳鼻喉眼学报 ›› 2018, Vol. 32 ›› Issue (2): 99-102.doi: 10.6040/j.issn.1673-3770.0.2017.354

• ·论著· • 上一篇    下一篇

IgG4相关性眼病伴继发性青光眼病例分析

谢洪彬,杨美娜,陈青山,刘旭阳,樊宁   

  1. 知识创新; JCYJ20150401163247234);
    深圳市科技计划项目基础研究(自由探索; JCYJ20160428144701106)第一作者:谢洪彬。 E-mail:401982083@qq.com通讯作者:樊宁。 E-mail:szfanning@126.comDOI:10.6040/j.issn.1673-3770.0.2017.354IgG4相关性眼病伴继发性青光眼病例分析谢洪彬, 杨美娜, 陈青山, 刘旭阳, 樊宁(深圳市眼科医院 暨南大学附属深圳眼科医院 深圳大学眼视光学院, 广东 深圳 518020
  • 收稿日期:2017-08-16 出版日期:2018-03-20 发布日期:2018-03-20
  • 通讯作者: 樊宁. E-mail:szfanning@126.com
  • 基金资助:
    深圳市科技计划项目基础研究(知识创新)(JCYJ20150401163247234);深圳市科技计划项目基础研究(自由探索)(JCYJ20160428144701106)

Analysis of immunoglobulin G4-related ophthalmic disease associated with secondary glaucoma

XIE Hongbin, YANG Meina, CHEN Qingshan, LIU Xuyang, FAN Ning   

  1. Shenzhen Eye Hospital, Affiliated Shenzhen Eye Hospital of Jinan University, Joint College of Optometry of Shenzhen University, Shenzhen 518020, Guangdong, China
  • Received:2017-08-16 Online:2018-03-20 Published:2018-03-20

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摘要： 目的 免疫球蛋白G4-相关性疾病(IgG4-RD)是近年来逐渐被认识的一类相对少见的、与淋巴细胞密切相关的系统性疾病,IgG4-RD可累及一个或多个器官,当累及眼部组织时,则称为IgG4相关性眼病(IgG4-ROD)。本文分析IgG4相关性眼病伴继发性青光眼病例,探讨其治疗方法。 方法 分析IgG4相关性眼病伴继发性青光眼患者临床表现,综合组织活检、影像学检查、患者对激素治疗的应答以及长期观察等因素。 结果 血清IgG4水平升高是考虑该病最重要的血清学特征,具有较高的诊断价值,但特异性不高。本病需长期使用糖皮质激素治疗,多数患者对激素治疗应答良好,临床症状和器官功能均可得到改善,IgG4水平也有所降低。 结论 IgG4-ROD导致继发性青光眼是其并发症之一,其手术方式的选择和术后远期效果缺乏临床经验。该病变本身及长期使用激素所引起的眼部并发症值得关注。

关键词: IgG4相关性眼病, 糖皮质激素, 继发性青光眼

Abstract: Objective Immunoglobulin(Ig)G4-related disease has recently been recognized as a relatively rare systemic lesion with abnormal lymphocytes. IgG4-related disease can involve one or multiple organs, and is called IgG4-related ophthalmic disease(IgG4-ROD)when ocular tissue is involved. To analysis of IgG4-ROD associated with secondary glaucoma and to discuss its treatment method. Methods We analyzed clinical manifestations, biopsy, imaging examinations, the response to hormone therapy, and long-term observation. Results The serum IgG4 level is considered the most important serologic characteristic of the disease and has high diagnostic value but lacks specificity. Most patients respond to long-term glucocorticoid therapy, typically with symptomatic improvement, reductions in the size of masses or organ enlargement, improvement in organ function, and often a decrease in serum IgG4 levels. Conclusion Secondary glaucoma is one of the complications associated with IgG4-ROD, but there is still no consensus regarding the choice of surgical procedure, and the long-term postoperative outcome is unknown. It is important to recognize and address the complications of IgG4-ROD and the side effects associated with use of corticosteroids.

Key words: IgG4-related ophthalmic disease, Corticosteroid, Secondary glaucoma

中图分类号: 

  • R775.3
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