慢性鼻窦炎嗅觉障碍嗅上皮中IGF-1R和Ki-67的表达及意义

山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (3): 55-.

慢性鼻窦炎嗅觉障碍嗅上皮中IGF-1R和Ki-67的表达及意义

刘庆华1，李志春2

1.厦门大学附属第一医院耳鼻咽喉-头颈外科，福建厦门 361003；
2.福建医科大学附属第一医院耳鼻咽喉-头颈外科，福建福州 350004

收稿日期:2010-12-12 修回日期:2011-01-24 出版日期:2011-06-16 发布日期:2011-06-16
通讯作者: 李志春，男，主任医师，教授，主要从事鼻科疾病的临床与基础研究。
作者简介:刘庆华（1980- ），男，主治医师，主要从事鼻科学的临床与基础研究。 Email：liuqinghua529@sina.com

IGF-1R and Ki-67 expressions in olfactory epithelium of patients suffering from dysosmia caused by chronic sinusitis

LIU Qing-hua1, LI Zhi-chun2

Department of Otolaryngology & Head and Neck Surgery, 1. Affiliated First Hospital of Xiamen University, Xiamen 361003, Fujian, China;
2. Affiliated First Hospital of Fujian Medical University, Fuzhou 350004, Fujian, China

Received:2010-12-12 Revised:2011-01-24 Online:2011-06-16 Published:2011-06-16

摘要/Abstract

摘要：

目的探讨慢性鼻－鼻窦炎嗅觉功能障碍的发病机制和胰岛素样生长因子－1R（insulin-like growth factor 1 R， IGF-1R）和Ki-67在嗅黏膜中表达的意义。方法取32例慢性鼻－鼻窦炎患者作为失嗅组，11例单纯鼻中隔偏曲行鼻中隔矫正术者作为对照组，应用免疫组织化学技术检测IGF-1R和Ki-67在两组嗅黏膜表达的分布。结果与对照组相比，实验组嗅黏膜Ki-67和IGF-1R表达明显减少（P<0.05）。结论慢性鼻-鼻窦炎嗅黏膜的再生能力明显减弱，与IGF1R减少有关。

关键词: 胰岛素样生长因子1R; Ki67;鼻窦炎；嗅上皮；嗅觉障碍

Abstract:

Objective To study the pathogenesis of dysosphresia in patients with chronic sinusitis, and to discuss expressions and significance of IGF-1R and Ki-67 in olfactory mucosa. Methods There were 32 cases of chronic sinusitis in the experimental group, and 11 cases in the control group. IGF-1R and Ki-67 expressions were determined by immunohistochemistry.Tissue sections were observed under an optical microscope. Results Expressions of IGF-1R and Ki-67 in the olfactory epithelium of 32 patients suffering from the dysosmia were lighter than those in the control group(P<0.05). Conclusion IGF-1R promoting regeneration in the olfactory epithelium was notably decreased in the ofactory epithelium of chronic sinusitis patient and may lead to ofactory dysfunction.

Key words: Insulin-like growth factor 1 R; Ki-67; Sinusitis; Olfactory epithelium; Dysosmia

中图分类号:

R765.6+3

刘庆华1，李志春2. 慢性鼻窦炎嗅觉障碍嗅上皮中IGF-1R和Ki-67的表达及意义[J]. 山东大学耳鼻喉眼学报, 2011, 25(3): 55-.

LIU Qing-hua1, LI Zhi-chun2. IGF-1R and Ki-67 expressions in olfactory epithelium of patients suffering from dysosmia caused by chronic sinusitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 55-.

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