IL-17在慢性鼻-鼻窦炎患者血浆中的表达及其意义

山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (3): 58-61.

IL-17在慢性鼻-鼻窦炎患者血浆中的表达及其意义

韩学锋，张磊，魏晓，李学忠

山东大学齐鲁医院耳鼻咽喉-头颈外科，济南 250012

收稿日期:2011-03-28 修回日期:2011-05-02 出版日期:2011-06-16 发布日期:2011-06-16
通讯作者: 李学忠(1964- ),男,医学博士,主任医师,教授,主要从事鼻科学的基础与临床研究工作。 Email: lxzebyh@163.com
作者简介:韩学锋(1983- ),男,硕士研究生,主要从事鼻科学的研究工作。 Email:hl-doctor@163.com
基金资助:
山东省科技攻关项目（2010G0020236）。

The plasma levels of IL-17 and its significance in chronic rhinosinusitis

HAN Xue-feng, ZHANG Lei, WEI Xiao, LI Xue-zhong

Department of Otolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University, Jinan 250012, China

Received:2011-03-28 Revised:2011-05-02 Online:2011-06-16 Published:2011-06-16

摘要/Abstract

摘要：

目的本实验旨在研究IL-17在慢性鼻-鼻窦炎患者血浆中的表达情况，探讨其在慢性鼻-鼻窦炎发生发展中的影响机制。方法收集伴有鼻息肉慢性鼻鼻窦炎患者38例(CRSwNP)、不伴有鼻息肉慢性鼻-鼻窦炎(CRSsNP)患者32例（柠檬酸钠抗凝）及对照组来自于门诊体检健康者28例的空腹晨血，采用ELISA法检测血浆中IL-17的含量。结果正常对照组血浆IL-17的浓度为 1.6100（1.2575~1.9830)pg／mL ；慢性鼻-鼻窦炎组为8．2483（4.8868~10.1075) pg／mL； CRSwNP组为8.2430(6.2778~10.3610) pg／mL ； CRSsNP组为8.2550（4.8783~10.1650) pg／mL。IL-17在正常人与慢性鼻-鼻窦炎患者血浆中表达差异有统计学意义（P＜0.05），但在CRSwNP 组与CRSsNP组差异无统计学意义。结论慢性鼻-鼻窦炎患者血浆中IL-17明显高于正常人，推测其在慢性鼻-鼻窦炎的发生发展中起重要作用。

关键词: IL-17；慢性鼻-鼻窦炎；鼻息肉

Abstract:

Objective To detect expression of IL-17 in the plasma of chronic rhinosinusitis patients, and to investigate the possible role of IL-17 in the mechanism of chronic rhinosinusitis. Methods All the enrolled patients were divided into 3 groups: the chronic rhinosimusitis with nasal polyps (CRSwNP) group (38 cases), theCRSsNP group (32 cases), and the control group (28 cases). The plasma level of IL-17 was detected by ELISA. Results ① The plasma level of IL-17 was 1.6100（1.2575-1.9830) pg/mL in the control group, 8.2483(4.8868-10.1075) pg/mL in the chronic rhinosinusitis group, of which it was 8.2430(6.2778-10.3610) pg/mL in the CRSwNP group and 8.2550（4.8783-10.1650) pg/mL in the CRSsNP group. ② A significant difference was found between the chronic rhino-sinusitis group and the control group(P<0.05). Expression of IL-17 in the CRSwNP and CRSsNP groups was significantly higher than that in the control group. However, there was no significant difference between the CRSwNP and CRSsNP groups in expression of IL-17. Conclusion The plasma level of IL-17 in chronic rhino-sinusitis patients was significantly higher than that of normal people, suggesting that IL-17 might play an important role in the development of chronic rhinosinusitis.

Key words: IL-17; Chronic rhinosinusitis；Nasal polyps

中图分类号:

R765.4

韩学锋，张磊，魏晓，李学忠. IL-17在慢性鼻-鼻窦炎患者血浆中的表达及其意义[J]. 山东大学耳鼻喉眼学报, 2011, 25(3): 58-61.

HAN Xue-feng, ZHANG Lei, WEI Xiao, LI Xue-zhong. The plasma levels of IL-17 and its significance in chronic rhinosinusitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 58-61.

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