Caveolin-1在下咽鳞癌中的表达及其临床意义

山东大学耳鼻喉眼学报 ›› 2012, Vol. 26 ›› Issue (5): 22-24.

Caveolin-1在下咽鳞癌中的表达及其临床意义

叶萍，孙睿杰，金童，钱晔，魏东敏，潘新良

山东大学齐鲁医院耳鼻咽喉头颈外科；卫生部耳鼻咽喉科学重点实验室，济南 250012

收稿日期:2012-03-31 发布日期:2012-10-16
通讯作者: 潘新良，博士生导师。E-mail:panxinl@yahoo.com.cn
作者简介:叶萍。E-mail:yeping0531@yahoo.com.cn
基金资助:
国家自然科学基金(30772411)

Expression and significance of Caveolin-1 in hypopharyngeal carcinoma

YE Ping, SUN Rui-jie, JIN Tong, QIAN Ye, WEI Dong-min, PAN Xin-liang

Department of Otorhinolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University/Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan 250012, China

Received:2012-03-31 Published:2012-10-16

摘要/Abstract

摘要：

目的研究Caveolin-1在下咽鳞癌组织中的表达情况，探讨其在下咽鳞癌发生发展中的作用机制。方法采用免疫组化法检测Caveolin-1在69例下咽鳞癌及10例癌旁正常组织中的表达，统计分析两者之间的相关性。结果 Caveolin-1在下咽癌组织中的阳性率为34.78%，在对照组中Caveolin-1存在个别表达或无阳性表达，两者表达差异有统计学意义(P<0.05)；Caveolin-1的表达程度与病理类型、转移相关，而与下咽鳞癌患者性别、临床分期和原发部位之间差异无统计学意义(P>0.05)。结论下咽鳞癌中Caveolin-1的表达明显增高并与肿瘤的转移行为有关，有可能作为下咽鳞癌预后不良的病理标志之一。

关键词: 下咽肿瘤；肿瘤，鳞状细胞；Caveolin-1

Abstract:

Objective To evaluate the expression of caveolin-1 in hypopharyngeal squamous cell carcinoma (HSCC) and investigate its association with pathological features and clinical outcome. Methods Caveolin-1 expression was determined by immunohistochemistry using rabbit polyclonal antibody against caveolin-1 in 69 paraffin embedded primary HSCC and 10 normal hypopharyngeal mucosa specimens. Associations between caveolin-1 expression and pathological features and clinical outcomes were analyzed with a chi-square test. Results The caveolin-1 expression in HSCC was much higher than in the normal mucosa. The positive rate of caveolin-1 was 0% in the normal mucosa but 34.78% in the primary tumors. Increased caveolin-1 expression had been reported to be associated with various pathological parameters, including higher Gleason score and lymph node metastasis. Although no significant association between caveolin-1 expression and gender or primary position was observed, caveolin1 was distinctively increased in cases with lymph node metastases (P<0.05). Conclusion Over-expression of Caveolin-1 could be a common finding in the aggressive types of HSCC. Caveolin-1 might play an important role in invasion and metastatic progression of HSCC.

Key words: Hypopharyngeal carcinoma; Squamous cell carcinoma; Caveolin-1

中图分类号:

R739.6

叶萍，孙睿杰，金童，钱晔，魏东敏，潘新良. Caveolin-1在下咽鳞癌中的表达及其临床意义[J]. 山东大学耳鼻喉眼学报, 2012, 26(5): 22-24.

YE Ping, SUN Rui-jie, JIN Tong, QIAN Ye, WEI Dong-min, PAN Xin-liang. Expression and significance of Caveolin-1 in hypopharyngeal carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(5): 22-24.

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