山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (1): 49-51.doi: 10.6040/j.issn.1673-3770.0.2014.342

• 论著 • 上一篇    下一篇

0.1%环孢素滴眼液联合玻璃酸钠滴眼液治疗眼干燥症

张菊, 吴欣怡   

  1. 山东大学齐鲁医院眼科, 山东 济南 250012
  • 收稿日期:2014-10-19 出版日期:2015-02-16 发布日期:2015-02-16
  • 通讯作者: 吴欣怡。E-mail:xywu8868@163.com E-mail:xywu8868@163.com
  • 作者简介:张菊。E-mail:845600140@qq.com

Effects of 01% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome

ZHANG Ju, WU Xin-yi   

  1. Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-10-19 Online:2015-02-16 Published:2015-02-16

摘要: 目的 观察0.1%环孢素滴眼液联合玻璃酸钠滴眼液治疗眼干燥症的疗效。方法 将60例(120眼)随机分为实验组与对照组,每组30例(60眼)。实验组每日给予0.1%环孢素滴眼液联合玻璃酸钠滴眼液,每日3次,1滴/次。对照组每日给予玻璃酸钠滴眼液,每日3次,1滴/次。两组均连续用药1个月。均以1个月为一疗程,治疗前后均行基础泪液分泌试验(SIt)、泪膜破裂时间(BUT)、角膜荧光素染色(FLs)检查,并对结果进行统计学分析。结果 治疗前两组SIt、BUT、FLs差异均无统计学意义(P>0.05)。治疗后两组SIt、BUT、FLs均较治疗前改善,差异有统计学意义(P<0.05)。治疗后实验组SIt、BUT、FLs优于对照组(P<0.05)。结论 0.1%环孢素滴眼液联合玻璃酸钠滴眼液治疗眼干燥症能有效缓解眼部不适症状,优于单用玻璃酸钠滴眼液。

关键词: 环孢素滴眼液, 人工泪液, 眼干燥症

Abstract: Objective To evaluate the effects of 0.1% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome. Methods A total of 60 patients (120 eyes) with dry eye syndrome were randomly divided into the experimental group (60 eyes) treated by 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops and the control group (60 eyes) treated by bysodium hyaluronate eye drops. Both groups were measured the Schirmer I test(SIt), tear film break-up time(BUT) and corneal fluorescein staining(FLs) before and after a month. Results There were no significant differences between the experimental group and the control group in SIt, BUT and FLs before treatment (P>0.05). After treatment, all the indicators of SIt, BUT and FLs of the experimental group and the control group were better than before (P<0.05). The experimental group was superior to the control group in the three indicators (SIt, BUT and FLs)(P<0.05). Conclusion 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops is effective in treatment of dry eye, and is superior to bysodium hyaluronate eye drops alone.

Key words: Dry eye syndrome, Cyclosporin eye drops, Artificial tears

中图分类号: 

  • R777.2
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[1] 杨梓超, 王育良. 眼干燥症的病因、发病机制及中西医结合治疗进展[J]. 山东大学耳鼻喉眼学报, 2015, 29(2): 91-93.
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