山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (5): 43-46.doi: 10.6040/j.issn.1673-3770.0.2015.290

• 论著 • 上一篇    下一篇

变应性鼻炎患者外周血EOS-CSF、IL-5水平及EOS数目对局部皮质类固醇激素治疗效果的评价

张辉1, 郑成彩2, 冯慧伟1, 郭成浩3   

  1. 1. 山东大学第二医院耳鼻咽喉头颈外科, 山东 济南 250033;
    2. 日照市东港区人民医院耳鼻咽喉科, 山东 日照 276800;
    3. 山东大学医学院, 山东 济南 250012
  • 收稿日期:2015-07-13 修回日期:2015-09-21 出版日期:2015-10-16 发布日期:2015-10-16
  • 通讯作者: 郭成浩,E-mail:chenghaoguo@sdu.edu.cn E-mail:chenghaoguo@sdu.edu.cn
  • 作者简介:张辉,E-mail:lucy_zhang@sdu.edu.cn
  • 基金资助:
    山东省科技攻关项目(2009gg10002025)

Valuation of the therapeutic effect of the nasal steroid hormone spray to detect EOS-CSF, IL-5 levels, EOS number of peripheral blood in allergic rhinitis patients

ZHANG Hui1, ZHENG Chengcai2, FENG Huiwei1, GUO Chenghao3   

  1. 1. Department of Otolaryngology & Head and Neck Surgery, The Second Hospital of Shandong Uuniversity, Jinan 250033, Shandong, China;
    2. Department of Otolaryngology, The Donggang Hospital of Rizhao City, Rizhao 276800, Shandong, China;
    3. The Medical School of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-07-13 Revised:2015-09-21 Online:2015-10-16 Published:2015-10-16

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摘要： 目的 检测持续性中重度变应性鼻炎(AR)患者局部应用皮质类固醇激素治疗前后外周血中嗜酸粒细胞集落形成因子(EOS-CSF)、白介素5(IL-5)的水平,判断AR症状缓解以及临床药物治疗效果评价的方便快速的实验室指标。方法 研究分AR组、AR治疗4周组、AR治疗12周组及正常对照组。采用ELAISA方法检测外周血EOS-CSF、IL-5水平,常规计数外周血嗜酸粒细胞(EOS)。应用视觉模拟量表(VAS)评价患者的鼻部症状。结果 AR组血中EOS-CSF和IL-5水平及外周血中EOS数目明显高于正常对照组。AR治疗4、12周组与AR相比,IL-5和EOS-CSF水平及外周血中EOS数目都明显降低。患者血清IL-5水平与EOS计数呈正相关(r=0.63, P<0.05);血清EOS-CSF水平与EOS计数呈正相关(r=0.68, P<0.05)。结论 经鼻用类固醇激素治疗后,检测外周血EOS-CSF和IL-5及查外周血EOS数目可用以监测变应性鼻炎治疗效果并对调整用药提供指导。

关键词: 鼻炎, 嗜酸粒细胞集落形成因子, 嗜酸粒细胞, 变应性, 白介素5

Abstract: Objective To detect the levels of eosinophil colony stimulating factor (EOS-CSF), interleukin-5(IL-5) and eosinophil(EOS) numbers in persistent moderately and severe allergic rhinitis patients'peripheral blood and to investigate the relationship between the levels of EOS-CSF and IL-5 and the clinic symptom of AR patients after using the Mometasone Furoate Aqueous Nasal Spray. Methods The levels of EOS-CSF and IL-5 in peripheral blood serum were detected by enzyme linked immunosorbent assay (ELISA). The number of EOS of fresh blood smear were observed by stained by Wright Giemsa method. The patients' nasal symptoms were evaluated by visual analogue scale. Results The levels of IL-5 and EOS-CSF and the EOS number in the AR group were significantly higher than in the normal control group.There was significant reduction of IL-5 and EOS-CSF in the patients after therapy. The data showed that the IL-5 level and EOS-CSF were positively correlated with EOS number. Conclusion Detection EOS-CSF, IL-5 and EOS number of peripheral blood in AR patients after treatment with nasal steroid hormone can be used to monitor the efficacy of treatment and provide guidance to adjust medication.

Key words: Allergic rhinitis, Interleukin 5, Eosinophil, Eosinophil colony stimulating factor

中图分类号: 

  • R765.4
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