山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (2): 75-77.doi: 10.6040/j.issn.1673-3770.0.2015.381

• 论著 • 上一篇    下一篇

七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎女性患者的疗效及安全性

李存杰1,孙宇2   

  1. 1.汉中市人民医院内分泌科, 陕西 汉中 723000;
    2.山东大学齐鲁医院内分泌科, 山东 济南 250012
  • 收稿日期:2015-09-05 出版日期:2016-04-16 发布日期:2016-04-16
  • 通讯作者: 孙宇. E-mail:sunyujn@aliyun.com E-mail:licunjie1972@126.co
  • 作者简介:李存杰. E-mail:licunjie1972@126.co

Clinical effect and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis.

LI Cunjie1, SUN Yu   

  1. 1. Department of Endocrinology, Peoples Hospital of Hanzhong City, Hanzhong 723000, Shaanxi, China;2. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-09-05 Online:2016-04-16 Published:2016-04-16

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摘要： 目的 评价七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎女性患者的临床疗效及安全性。 方法 选取亚急性甲状腺炎女性患者80例,随机分为观察组和对照组,各40例。对照组口服泼尼松30 mg/d,分3次服用;治疗第三个周,口服泼尼松20 mg/d,分3次服用;随后每两周剂量减少5 mg,直至停药。观察组口服泼尼松5 mg/d,同时静脉滴注七叶皂苷钠10 mg/d,每10 d为一个疗程,每个疗程之间间隔一周,共治疗4周。于治疗前、治疗7 d、治疗1个月,以及治疗2个月时,检测两组患者促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、红细胞沉降率(ESR)、C-反应蛋白(CRP)以及纤维蛋白原(FIB)水平,症状消失时间及不良反应。 结果 组内比较,两组治疗前后不同时间点FT3、FT4、ESR、CRP、TSH水平差异具有统计学意义(P<0.05或P<0.01)。组间比较,治疗7 d时,观察组ESR、CRP、TSH低于对照组(P<0.05或P<0.01);治疗1个月时,观察组FT4、ESR低于对照组(P<0.01);治疗2个月,观察组CRP、FIB低于对照组(P<0.05)。观察组的症状缓解时间低于对照组(P<0.01),不良反应发生率低于对照组(P<0.01)。 结论 七叶皂苷钠联合小剂量的泼尼松治疗亚急性甲状腺炎患者,起效快、疗效好,不良反应少,值得临床推广应用。

关键词: 泼尼松, 七叶皂苷钠, 亚急性甲状腺炎

Abstract: Objective To investigate the efficacyt and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis. Methods A total of 80 patients with subacute thyroiditis were collected and randomly divided into the observation group and control group, with 40 cases in either group. Patients in the control group were given a total dosage of 30 mg/d oral prednisone, divided into 3 times per day. Two weeks later these patients were given a total dosage of 20 mg/d oral prednisone, divided into 3 times per day. Then the dosage was reduced by 5 mg every 2 weeks till withdrawal. Patients in the observation group were treated with 5 mg/d oral prednisone combined with 10 mg/d intravenous sodium aescinate. A 10-day course was set with an interval of 7 days. The treatment lasted for 4 weeks. The levels of thyroid stimulating hormone(TSH), free three iodine thyroid original ammonia acid(FT3), free thyroxine(FT4), red cell sedimentation rate(ESR), C-reactive protein(CRP)and fibrinogen(FIB)before treatment, 7 days, 1 month and 2 months after treatment were compared. The symptom alleviating time and incidence of adverse reactions in both groups were observed. Results Intra-group comparison: FT3, FT4, ESR, CRP, TSH levels showed statistical significances at different time points before and after treatment in the 2 groups respectively(P<0.05 or P<0.01). Inter-group comparison: ESR, CRP, TSH levels were lower in the observation group than in the control group 7 days after treatment(P<0.05 or P<0.01). FT4 and ESR levels were lower in the observation group than in the control group 1 month after treatment(P<0.01). CRP and FIB levels were lower in the observation group than in the control group 2 months after treatment(P<0.05). The symptom alleviating time and incidence of adverse reactions were lower in the observation group than in the control group(P<0.01). Conclusion Sodium aescinate combined with low dosage of prednisone is safe and effective in the treatment of subacute thyroiditis and worth of wide clinical application.

Key words: Sodium aescinate, Prednisone, Subacute thyroiditis

中图分类号: 

  • R581.4
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