山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (2): 75-77.doi: 10.6040/j.issn.1673-3770.0.2015.381

• 论著 • 上一篇    下一篇

七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎女性患者的疗效及安全性

李存杰1,孙宇2   

  1. 1.汉中市人民医院内分泌科, 陕西 汉中 723000;
    2.山东大学齐鲁医院内分泌科, 山东 济南 250012
  • 收稿日期:2015-09-05 出版日期:2016-04-16 发布日期:2016-04-16
  • 通讯作者: 孙宇. E-mail:sunyujn@aliyun.com E-mail:licunjie1972@126.co
  • 作者简介:李存杰. E-mail:licunjie1972@126.co

Clinical effect and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis.

LI Cunjie1, SUN Yu   

  1. 1. Department of Endocrinology, Peoples Hospital of Hanzhong City, Hanzhong 723000, Shaanxi, China;2. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2015-09-05 Online:2016-04-16 Published:2016-04-16

HTML

PDF (PC)

765

摘要： 目的 评价七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎女性患者的临床疗效及安全性。 方法 选取亚急性甲状腺炎女性患者80例,随机分为观察组和对照组,各40例。对照组口服泼尼松30 mg/d,分3次服用;治疗第三个周,口服泼尼松20 mg/d,分3次服用;随后每两周剂量减少5 mg,直至停药。观察组口服泼尼松5 mg/d,同时静脉滴注七叶皂苷钠10 mg/d,每10 d为一个疗程,每个疗程之间间隔一周,共治疗4周。于治疗前、治疗7 d、治疗1个月,以及治疗2个月时,检测两组患者促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、红细胞沉降率(ESR)、C-反应蛋白(CRP)以及纤维蛋白原(FIB)水平,症状消失时间及不良反应。 结果 组内比较,两组治疗前后不同时间点FT3、FT4、ESR、CRP、TSH水平差异具有统计学意义(P<0.05或P<0.01)。组间比较,治疗7 d时,观察组ESR、CRP、TSH低于对照组(P<0.05或P<0.01);治疗1个月时,观察组FT4、ESR低于对照组(P<0.01);治疗2个月,观察组CRP、FIB低于对照组(P<0.05)。观察组的症状缓解时间低于对照组(P<0.01),不良反应发生率低于对照组(P<0.01)。 结论 七叶皂苷钠联合小剂量的泼尼松治疗亚急性甲状腺炎患者,起效快、疗效好,不良反应少,值得临床推广应用。

关键词: 泼尼松, 七叶皂苷钠, 亚急性甲状腺炎

Abstract: Objective To investigate the efficacyt and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis. Methods A total of 80 patients with subacute thyroiditis were collected and randomly divided into the observation group and control group, with 40 cases in either group. Patients in the control group were given a total dosage of 30 mg/d oral prednisone, divided into 3 times per day. Two weeks later these patients were given a total dosage of 20 mg/d oral prednisone, divided into 3 times per day. Then the dosage was reduced by 5 mg every 2 weeks till withdrawal. Patients in the observation group were treated with 5 mg/d oral prednisone combined with 10 mg/d intravenous sodium aescinate. A 10-day course was set with an interval of 7 days. The treatment lasted for 4 weeks. The levels of thyroid stimulating hormone(TSH), free three iodine thyroid original ammonia acid(FT3), free thyroxine(FT4), red cell sedimentation rate(ESR), C-reactive protein(CRP)and fibrinogen(FIB)before treatment, 7 days, 1 month and 2 months after treatment were compared. The symptom alleviating time and incidence of adverse reactions in both groups were observed. Results Intra-group comparison: FT3, FT4, ESR, CRP, TSH levels showed statistical significances at different time points before and after treatment in the 2 groups respectively(P<0.05 or P<0.01). Inter-group comparison: ESR, CRP, TSH levels were lower in the observation group than in the control group 7 days after treatment(P<0.05 or P<0.01). FT4 and ESR levels were lower in the observation group than in the control group 1 month after treatment(P<0.01). CRP and FIB levels were lower in the observation group than in the control group 2 months after treatment(P<0.05). The symptom alleviating time and incidence of adverse reactions were lower in the observation group than in the control group(P<0.01). Conclusion Sodium aescinate combined with low dosage of prednisone is safe and effective in the treatment of subacute thyroiditis and worth of wide clinical application.

Key words: Sodium aescinate, Prednisone, Subacute thyroiditis

中图分类号: 

  • R581.4
[1] 李新秋, 王玉明. 七叶皂苷钠联合小剂量泼尼松治疗亚急性甲状腺炎20例疗效观察[J]. 海南医学, 2013, 24(1):9-11. LI Xinqiu, WANG Yuming. Clinical effect of sodium aescinate combined with low-dose prednisolonum in the treatment of 20 cases of subacute thyroiditis[J]. Hainan Med J, 2013, 24(1):9-11.
[2] 张星. 地塞米松与七叶皂苷钠联合治疗亚急性甲状腺炎临床效果评价[J]. 现代仪器与医疗, 2015, 21(3):103-104,107. ZHANG Xing. 地塞米松与七叶皂苷钠联合治疗亚急性甲状腺炎临床效果评价[J]. Modern Instruments & Mediccal Treatment, 2015, 21(3):103-104, 107.
[3] 陆静毅, 周健, 包玉倩, 等. Graves病合并亚急性甲状腺炎的临诊应对[J]. 中华内分泌代谢杂志, 2014, 30(6):523-525. LU Jingyi, ZHOU Jian, BAO Yuqian, et al. approach to the patient with graves’ disease and concomitant subacute thyroiditis: diagnosis and treatment[J]. Chin J Endocrinology and Metabolism, 2014, 30(6):523-525.
[4] 崔焕焕, 李艳玲, 卢斌, 等. 血清C反应蛋白在亚急性甲状腺炎诊断中的应用[J]. 中华内分泌代谢杂志, 2014, 30(5):414-416. CUI Huanhuan, LI Yanling, LU Bin, et al. Application of serum c-reactive protein in the diagnosis of subacute thyroiditis[J]. Chin J Endocrinology and Metabolism, 2014, 30(5):414-416.
[5] 应长江, 周晓燕, 周冬梅, 等. 清开灵联合糖皮质激素治疗亚急性甲状腺炎疗效观察[J]. 现代中西医结合杂志, 2015, 24(18):1995-1996, 1997. YING Changjiang, ZHOU Xiaoyan, ZHOU Dongmei, et al. To observe the curative effect of Qingkailing combined with glucocorticoids in the treatment of subacute thyroiditis[J]. Modern J Integrated Traditional Chin and West Med, 2015, 24(18):1995-1996, 1997.
[6] Bernecker C, Ostapczuk M, Vordenbäumen S, et al. HLA-A2 phenotype may be protective against Graves’ disease but not against Hashimotos thyroiditis in Caucasians[J]. Horm Metab Res, 2013, 45(1):74-77.
[7] 邵致格, 袁群, 韦亚萍. 单点和多点甲状腺肿块内注射地塞米松治疗亚急性甲状腺炎的比较[J]. 实用医学杂志, 2013, 29(17):2930-2931. SHAO Zhige, YUAN Qun, WEI Yaping. Comparison between mono- and multi- point intrathyroidal injection of dexamethasone to treat subacute thyroiditis[J]. J Practical Med, 2013, 29(17):2930-2931.
[8] Wang C J, Wu T J, Lee C T, et al. A misdiagnosed riedels thyroiditis successfully treated by thyroidectomy and tamoxifen[J]. J Formos Med Assoc, 2012, 111(12):719-723.
[9] 梅珊珊, 宋海庆, 丁建平, 等. 七叶皂苷钠的不良反应及防治[J]. 中华临床医师杂志(电子版), 2012, 6(24):8289-8291. MEI Shanshan, SONG Haiqing, DING Jianping, et al. Prevention and Cure of Adverse Reaction Caused by Escin Sodium Injection[J]. Chin J Clinicians(Electronic Edition), 2012, 6(24):8289-8291.
[10] 李常恩, 李新秋, 王玉明. 注射用七叶皂苷钠联合地塞米松磷酸钠注射液治疗亚急性甲状腺炎临床观察[J]. 河北中医, 2014, 36(8):1212-1214. LI Changen, LI Xinqiu, WANG Yuming. Observation of sodium aescine combined with intrathyroidal injection of dexamethasone on the treatment of subacute thyroiditis[J]. Hebei J Traditional Chin Med, 2014, 36(8):1212-1214.
[1] 严晓腾, 冯军. 分次激光联合泼尼松治疗孔源性局限性视网膜浅脱离的疗效分析[J]. 山东大学耳鼻喉眼学报, 2014, 28(4): 85-86.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 赵利敏，倪坤，吴佳丽，陈淑梅，李晓艳. 婴幼儿吸气性喉喘鸣病因分析与治疗[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 49 -51 .
[2] 史春生1，张庆泉2,王强2,孙岩2,葛长艺1. 软腭缺损修复组织瓣的特点[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 86 -88 .
[3] 张令1,孙传义1,许安廷2. 以耳聋就诊的岩尖胆脂瘤1例[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 93 -94 .
[4] 吴彦桥，邸斌，李军，高晓红 . 鼻内镜下难治性鼻出血出血点寻找及止血策略[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 1 -3 .
[5] 罗惠秀，范春涛，邓延华. 阻塞性睡眠呼吸暂停低通气综合征患儿扁桃体腺样体切除术临床疗效分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 17 -20 .
[6] 郝颖娟1，杨庆松2，周跃华2，易省平1，翟长斌2. 飞秒激光在薄瓣LASIK手术中制作的角膜瓣厚度形态观察[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 26 -31 .
[7] 闻华明1，李海祥2. 应用三角函数法估算LASIK术后人工晶状体度数[J]. 山东大学耳鼻喉眼学报, 2013, 27(5): 74 -76 .
[8] 朱见，贺青卿，郑鲁明，范子义，赵国伟，侯蕾，史后彬 . cN0甲状腺微小乳头状癌淋巴结转移高危因素及行预防性清扫临床分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(6): 9 -12 .
[9] 李少华，孙一帆，卢标清. 双软组织血管瓣填塞乳突术腔的临床研究[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 6 -7 .
[10] 魏希建1，阴瑞兰2，郭星3. 增殖诱导配体在喉鳞状细胞癌中的表达[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 14 -16 .
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发