胃食管反流病与喉癌关系的Meta分析

doi:10.6040/j.issn.1673-3770.0.2015.411

摘要/Abstract

摘要： 目的用Meta分析方法评价胃食管反流病与喉癌之间的关系。方法计算机检索Pubmed、Embase、Web of Knowledge、CBM和CNKI数据库,文献检索起至时间从建库到2015年5月止,收集公开发表的所有关于胃食管反流病与喉癌关系的病例对照研究,按纳入和排除标准筛选文献并评价纳入研究质量,应用RevMan 5.3和Stata13.1软件进行Meta分析,根据异质性检验结果选择模型并合并效应量OR值,并评价发表偏倚和敏感性分析。结果共纳入13个病例对照研究,Meta分析结果显示,喉癌组胃食管反流病的阳性率显著高于对照组［OR=2.68, 95%CI(1.94,3.70),P<0.000 01］。结论胃食管反流病可能是喉癌发生的一种危险因素。但是,考虑到研究间的异质性,还需设计更好的研究来进一步证明本Meta分析结论。

关键词: 胃食管反流病, 喉癌, Meta分析, 病例对照研究

Abstract: Objective To evaluate the relationship between gastroesophageal reflux disease and laryngeal carcinoma with meta-analyses. Methods The published studies of the relationship between gastroesophageal reflux disease and laryngeal carcinoma were searched in the Pubmed、Embase、Web of Knowledge、CBM and CNKI databases(from the date of establishment of the databases to May 2015). The trails selection based on inclusion and exclusion criteria, the quality of the included studies was assessed and meta-analysis was performed with RevMan 5.3 and Stata 13.1 software. The OR value of included studies were calculated after heterogeneity test and publication bias was assessed by Harbord method. Results A total of 13 studies were recruited. The Meta-analysis showed the positive rate of gastroesophageal reflux disease was significantly higher in the laryngeal carcinoma group compared with the control group ［OR=2.68, 95%CI(1.94, 3.70), P<0.000 01］. Conclusion Gastroesophageal reflux disease may be a significant risk factor for laryngeal carcinoma. However, given the heterogeneity of the published studies, future well-designed studies are needed.

Key words: Case-control study, Laryngeal carcinoma, Meta-analysis, Gastroesophageal reflux disease

中图分类号:

R739.6

李泽文,郭俊宇,周洁,严福波,杨志敏,丁珠华. 胃食管反流病与喉癌关系的Meta分析[J]. 山东大学耳鼻喉眼学报, 2016, 30(3): 40-46.

LI Zewen, GUO Junyu, ZHOU Jie, YAN Fubo, YANG Zhimin, DING Zhuhua. Relationship between gastroesophageal reflux disease and laryngeal carcinoma: a meta-analysis.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 40-46.

参考文献

[1] Pirzadeh A, Doustmohammadian N, Khoshbaten M, et al. Is there any association between Helicobacter Pylori infection and laryngeal carcinoma?[J]. Asian Pac J Cancer Prev, 2011, 12(4):897-900.
[2] Sturgis E M, Pytynia K B. After the smoke clears: environmental and occupational risks for carcinoma of the upper aerodigestivetract[J]. Cancer J, 2005, 11(2):96-103.
[3] Pavia M, Pileggi C, Nobile C G, et al. Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies[J]. Am J Clin Nutr, 2006, 83(5):1126-1134.
[4] Bacciu A, Mercante G, Ingegnoli A, et al. Effects of gastroesophageal reflux disease in laryngeal carcinoma[J]. Clin Otolaryngol Allied Sci, 2004, 29(5):545-548.
[5] Mercante G, Bacciu A, Ferri T, et al. Gastroesophageal reflux as a possible co-promoting factor in the development of the squamous-cell carcinoma of the oral cavity, of the larynx and of the pharynx[J]. Acta Otorhinolaryngol Belg, 2003, 57(2):113-117.
[6] El-Serag H B, Hepworth E J, Lee P, et al. Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer[J]. Am J Gastroenterol, 2001, 96(7):2013-2018.
[7] Doustmohammadian N, Naderpour M, Khoshbaten M, et al. Is there any association between esophagogastric endoscopic findings and laryngeal cancer?[J]. Am J Otolaryngol, 2011, 32(6):490-493.
[8] Vaezi M F, Qadeer M A, Lopez R, et al. Laryngeal cancer and gastroesophageal reflux disease: a case-control study[J]. Am J Med, 2006, 119(9):768-776.
[9] Cekin E, Ozyurt M, Erkul E, et al. The association between Helicobacter pylori and laryngopharyngeal reflux in laryngeal pathologies[J]. Ear Nose Throat J, 2012, 91(3):E6-E9.
[10] Koufman J A. The otolaryngologic manifestations of gastroesophageal reflux disease(GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury[J]. Laryngoscope, 1991, 101(4 Pt 2 Suppl53):1-78.
[11] Chen M Y, Ott D J, Casolo B J, et al. Correlation of laryngeal and pharyngeal carcinomas and 24-hour pH monitoring of the esophagus and pharynx[J]. Otolaryngol Head Neck Surg, 1998, 119(5):460-462.
[12] Ozlugedik S, Yorulmaz I, Gokcan K. Is laryngopharyngeal reflux an important risk factor in the development of laryngeal carcinoma?[J]. Eur Arch Otorhinolaryngol, 2006, 263(4):339-343.
[13] Francis D O, Maynard C, Weymuller E A, et al. Reevaluation of gastroesophageal reflux disease as a risk factor for laryngeal cancer[J]. Laryngoscope, 2011, 121(1):102-105.
[14] Wells G A, Shea B, OConnell D, et al. The Newcastle-Ottawa Scale(NOS)for assessing the quality of nonrandomized studies in meta-analyses[J]. Available: www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 25 November 2012.
[15] 张天嵩, 钟文昭, 张素, 等. Stata在Meta分析时异质性评价中的应用[J].循证医学, 2008,8(4): 231-234. ZHANG Tiansong, ZHONG Wenzhao, ZHANG Su, et al. Stata in assessing heterogeneity in meta-analysis[J]. J Evi-based Med, 2008, 8(4): 231-234.
[16] Harbord R M, Egger M, Sterne J A. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints[J]. Stat Med, 2006, 25(20):3443-3457.
[17] Dagli S, Dagli U, Kurtaran H, et al. Laryngopharyngeal reflux in laryngeal cancer[J]. Turk J Gastroenterol, 2004, 15(2):77-81.
[18] 赵一馨,张立红,张春芳,等. 喉癌患者并发咽喉反流的初步观察[J].中华耳鼻咽喉头颈外科杂志,2014,49(5):356-361. ZHAO Yixin, ZHANG Lihong, ZHANG Chunfang, et al. Research on the association of the laryngeal carcinoma and laryngopharyngeal reflux[J]. Chin J Otorhinolarynol Head Neck Surg, 2014, 49(5):356-361.
[19] Tae K, Jin B J, Ji Y B, et al. The role of laryngopharyngeal reflux as a risk factor in laryngeal cancer: a preliminary report[J]. Clin Exp Otorhinolaryngol, 2011, 4(2):101-104.
[20] Gabriel C E, Jones D G. The importance of chronic laryngitis[J]. J Laryngol Otol, 1960, 74:349-357.
[21] Krahulec I, Urbanova O, Simko S. Importance of laryngostroboscopic examination for diagnosis and therapy of chronic hypertrophic laryngitis[J]. Cesk Otolaryngol, 1976, 25(3):170-173.
[22] Wynder E L, Stellman S D. Comparative epidemiology of tobacco-related cancers[J]. Cancer Res, 1977, 37(12):4608-4622.
[23] Zeka A, Gore R, Kriebel D. Effects of alcohol and tobacco on aerodigestive cancer risks: a meta-regression analysis[J]. Cancer Causes Control, 2003, 14(9):897-906.

相关文章 15

[1]	叶树凤,张旭,苏凯,李贺杰,滕博. 喉癌喉部分切除术术后喉囊肿一例及文献复习[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 117-118.
[2]	李国彬,张占成,王新颜. 上调miR-200b对人喉癌Hep-2细胞增殖、迁移和侵袭能力的影响[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 53-57.
[3]	沈翎,林宗通,林兴,杨中婕. 儿童阻塞性睡眠呼吸暂停低通气综合征危险因素的[J]. 山东大学耳鼻喉眼学报, 2018, 32(2): 25-29.
[4]	林兴,林宗通,沈翎. 鼻窦球囊扩张治疗儿童慢性鼻窦炎的系统评价及Meta分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(6): 79-86.
[5]	张杰,陈雪梅,许安廷. 超声刀扁桃体切除术与低温等离子扁桃体切除术的对比研究[J]. 山东大学耳鼻喉眼学报, 2017, 31(5): 95-100.
[6]	王越,柯敏,韩芳芳,王文欢,翁鸿. EX-PRESS引流器植入术与小梁切除术治疗开角型青光眼有效性和安全性的Meta分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(2): 104-111.
[7]	许元腾,陈瑞庆,林功标,方秀玲,俞舒娟,梁晓华,张榕. RNAi沉默PDCD4基因对人喉癌Hep-2细胞增殖及β-catenin表达的影响[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 110-114.
[8]	包伟晶,宁佳羽,朱忠寿,魏日富,林昶. CO₂激光切除累及前联合的早期声门癌26例[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 101-105.
[9]	马玲国,郑朝攀,周敬淳,张博,龚桃根,张云静. CO₂激光治疗声门型喉癌远期疗效分析[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 98-100.
[10]	李晓明,宋琦,李红霞,陶振峰,申宇鹏,肖淑芬. 胸大肌肌皮瓣在侵犯下咽晚期头颈鳞癌手术切除术后缺损修复中的应用[J]. 山东大学耳鼻喉眼学报, 2016, 30(3): 4-9.
[11]	晋舒. 全喉切除术后气管感染对喉癌患者肺功能及肿瘤复发率的影响[J]. 山东大学耳鼻喉眼学报, 2016, 30(3): 37-39.
[12]	严羽, 朱江. 早期喉癌及喉癌前病变诊断的研究进展[J]. 山东大学耳鼻喉眼学报, 2015, 29(4): 80-85.
[13]	陈曦, 李进让. 鼻用激素治疗儿童阻塞性睡眠呼吸暂停低通气综合征疗效的Meta分析[J]. 山东大学耳鼻喉眼学报, 2015, 29(2): 9-11.
[14]	林丹，董伟达，陆美萍，邢光前，董佳迪，张伟强. MicroRNA-146a前体区基因多态性与江苏地区汉族人群喉癌遗传易感性的关联性分析[J]. 山东大学耳鼻喉眼学报, 2014, 28(2): 46-50.
[15]	徐媛媛，曾泉，洪苏玲，胡国华. 新辅助化疗联合同期放化疗与同期放化疗单独治疗鼻咽癌疗效及安全性的Meta分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(5): 8-14.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed