山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (4): 94-97.doi: 10.6040/j.issn.1673-3770.0.2015.526

• 论著 • 上一篇    下一篇

血浆1-3-β-D葡聚糖对真菌性鼻窦炎的诊断价值

余鹏举1, 许风雷2, 杨军1, 陈伟3, 江满杰3   

  1. 1. 江苏省昆山市中医医院耳鼻咽喉科, 江苏 昆山 215300;
    2. 山东大学第二医院耳鼻咽喉头颈外科, 山东 济南 250000;
    3. 南京军区南京总医院耳鼻咽喉-头颈外科, 江苏 南京 210002
  • 收稿日期:2015-12-11 出版日期:2016-08-16 发布日期:2016-08-16
  • 作者简介:余鹏举. E-mail:ypj1025@163.com

Diagnostic value of plasma 1-3-β-D glucan for fungal rhinosinusitis.

YU Pengju1, XU Fenglei2, YANG Jun1, CHEN Wei3, JIANG Manjie   

  1. 1. Department of otorhinolaryngology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan 215300, Jiangsu, China;2. ENT &HN Surgery Department, The Second Hospital of Shandong University, Jinan 250000, Shandong, China;3. Department of Otolaryngology-Head Neck Surgery, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu, China
  • Received:2015-12-11 Online:2016-08-16 Published:2016-08-16

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摘要： 目的 明确血浆1-3-β-D葡聚糖对真菌性鼻窦炎的诊断价值。 方法 选择2014年1月至2015年12月接受鼻窦炎手术的患者,依据术后病理诊断分为观察组(真菌性鼻窦炎)及对照组(细菌性鼻窦炎)。比较手术前后外周血1-3-β-D葡聚糖、C-反应蛋白(CRP)及降钙素原(PCT)的改变。 结果 共纳入符合研究条件的患者83例,其中观察组41例,对照组42例。观察组术前血浆1-3-β-D葡聚糖水平显著高于对照组(P<0.05),术后1-3-β-D葡聚糖水平显著降低(P<0.05)。相关性分析显示,观察组术前血浆1-3-β-D葡聚糖水平与PCT(t=0.701, P=0.002)及CRP(t=0.846, P=0.002)均呈现显著正相关。ROC曲线分析显示,当1-3-β-D葡聚糖取值为12.0 pg/mL时对感染的诊断敏感性为90.48%,特异性为95.12%,优于PCT及CPR。 结论 1-3-β-D葡聚糖对真菌性鼻窦炎的诊断较为可靠,有望成为辅助术前诊断的实用指标。

关键词: C-反应蛋白, 1-3-β-D葡聚糖, 真菌性鼻窦炎, 诊断, 降钙素原

Abstract: Objective To analyze the value of plasma 1-3-β-D glucan for diagnosis of fungal rhinosinusitis. Methods Patients with nasosinusitis underwent surgery treatment at our hospital from 2014 to 2015 were selected and divided into observation group(fungal rhinosinusitis)and control group(bacterial rhinosinusitis)according to the postoperative pathological diagnosis. Changes of 1-3-β-D glucan, C-reactive protein(CRP)and procalcitonin(PCT)in peripheral blood were compared. Results A total of 83 patients were enrolled, in which 41 cases were divided in observation group and 42 cases were divided in control group. Patients in observation group had a higher level of 1-3-β-D glucan than that of control group before surgery(P<0.05), but decreased significantly after surgery(P<0.05). Correlation analysis showed that, for patients in observation group, the levels of 1-3-β-D glucan had significant positive correlation with CRP(t=0.846, P=0.002)and PCT(t=0.701, P=0.002). ROC analysis showed that the 1-3-β-D glucan cut-off point value of 12.0 pg/mL, as used for the diagnosis of fungal rhinosinusitis, provided a sensitivity of 90.48%, a specificity of 95.12%, better than these of CRP and PCT. Conclusion Plasma 1-3-β-D glucan assay for diagnosis of fungal rhinosinusitis is reliable and it has potential to become a practical indicator for auxiliary preoperative diagnosis.

Key words: Diagnosis, C-reactive protein, 1-3-β-D glucan, Procalcitonin, Fungal rhinosinusitis

中图分类号: 

  • R765.4
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