山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (5): 1-4.doi: 10.6040/j.issn.1673-3770.0.2016.404

• 述评 •    下一篇

肥胖与阻塞性睡眠呼吸暂停

李延忠   

  1. 山东大学 齐鲁医院耳鼻咽喉头颈外科/卫生部耳鼻喉科学重点实验室, 山东 济南 250012
  • 收稿日期:2016-09-19 出版日期:2016-10-20 发布日期:2016-10-20
  • 通讯作者: 李延忠. E-mail:liyanzhong@sdu.edu.cn

Obesity and obstructive sleep apnea.

LI Yanzhong   

  1. Department of Otolaryngology &Head and Neck Surgery, Qilu Hospital of Shandong University / Key Laboratory of Otolaryngology of Health Ministry, Shandong University, Jinan 250012, Shandong, China
  • Received:2016-09-19 Online:2016-10-20 Published:2016-10-20

HTML

PDF (PC)

1174

摘要： 肥胖与OSA之间的关系是睡眠呼吸疾病领域一个新的热点,目前尚不清楚两者是因果关系还是伴随关系。肥胖胜过其他颅面畸形诱发阻塞性睡眠呼吸暂停(OSA),OSA 的频率与严重程度与体质量指数和肥胖相关,现就OSA与脂质代谢紊乱、脂肪肝、代谢性炎症、氧化应激四个方面的关系做一述评。

关键词: 氧化应激, 脂质代谢紊乱, 睡眠呼吸暂停,阻塞性, 脂肪肝, 代谢性炎症, 肥胖

Abstract: The relationship between obesity and obstructive sleep apnea-hypopnea syndrome(OSAHS)has become a new hot spot in the research of sleep-disordered breathing. Whether there is a cause-and-effect or accompanying relationship between them is not yet clear. Compared with craniofacial malformations, obesity is more likely to induce obstructive sleep apnea syndrome(OSA). The frequency and severity of OSA are related to BMI and obesity. This paper discusses the relationship from four aspects: lipid metabolism disorder, fatty liver, metabolic inflammation, and oxidative stress.

Key words: Obesity, Fatty liver, Metabolic inflammation, Obstructive sleep apnea hypopnea syndrome, Disorder of lipid metabolism, Oxidative stress

中图分类号: 

  • R766.7
[1] Malhotra A, White D P. Obstructive sleep apnea[J]. Lancet, 2002, 360(9328): 237-245.
[2] Olea E, Agapito M T, Gallego-Martin T, et al. Intermittent hypoxia and diet-induced obesity: effects on oxidative status, sympathetic tone, plasma glucose and insulin levels, and arterial pressure[J]. J Appl Physiol, 2014, 117(7): 706-19.
[3] Toyama Y, Chin K, Chihara Y, et al. Association between sleep apnea, sleep duration, and serum lipid profile in an urban, Smale, working population in Japan[J]. Chest, 2013, 143(3): 720-728.
[4] Ge H, Cha J Y, Gopal H, et al. Differential regulation and properties of Angiopoietin-like proteins 3 and 4[J]. J Lipid Res, 2005, 46(7): 1484-1490.
[5] Shimamura M, Matsuda M, Ando Y, et al. Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma riglyceride-increasing factor[J]. Biochem Biophys Res Commun, 2004, 322(3): 1080-1085.
[6] van Rossum C T, Hoebee B, van Baak M A, et al. Genetic variation in the leptin receptor gene leptin and weight gain in young Dutch adults[J]. Obes Res, 2003, 11(3): 377-86.
[7] Zhen Y Q, Wu Y M, Sang Y H, et al. 2, 3-Oxidosqualene cyclase protects liver cells from the injury of intermittent hypoxia by regulating lipid metabolism[J]. Sleep Breath, 2015, 19(4): 1475-1481.
[8] Gharib S A, Khalyfa A, Abdelkarim A, et al. Intermittent hypoxia activates temporally coordinated transcriptional programs in visceral adipose tissue[J]. J Mol Med(Berl), 2012, 90(4): 435-445.
[9] Tanne F, Gagnadoux F, Chazouilleres O, et al. Chronic liver injury during obstructive sleep apnea[J]. Hepatology, 2005, 41(6): 1290-1296.
[10] Sookoian S, Pirola C J. Obstructive sleep apnea is associated with fatty liver and abnormal liver enzymes: a meta-analysis[J]. Obes Surg, 2013, 23(11): 1815-1825.
[11] Musso G, Cassader M, Olivetti C, et al. Association of obstructive sleep apnea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis[J]. Obes Rev, 2013, 14(5): 417-431.
[12] Ar?soy A, Sertogullar?ndan B, Ekin S, et al. Sleep Apnea and Fatty Liver Are Coupled Via Energy Metabolism[J]. Med Sci Monit, 2016, 19(22): 908-913.
[13] St-Onge M P, Shechter A. Sleep disturbances, body fat distribution, food intake and/or energy expenditure: pathophysiological aspects[J]. Horm Mol Biol Clin Investig, 2014, 17(1): 29-37.
[14] Hotamisligil G S. Inflammation and metabolic disorders[J]. Nature, 2006, 444(7121): 860-867.
[15] Li J, Savransky V, Nanayakkara A, et al. Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia[J]. J Appl Physiol(1985), 2007, 102(2): 557-563.
[16] Savransky V, Nanayakkara A, Vivero A, et al. Chronic intermittent hypoxia predisposes to liver injury[J]. Hepatology, 2007, 45(4): 1007-1013.
[17] Lu C H, Lin H C, Huang C C, et al. Increased circulating endothelial progenitor cells and anti-oxidant capacity in obstructive sleep apnea after surgical treatment[J]. Clin Chim Acta, 2015, 25(448): 1-7.
[1] 张转,刘涛,白治丽,周长明. 氧化应激与噪音性聋发病机制及治疗进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(5): 101-103.
[2] 李小波,曹忠胜,辛洁,谢辰,陈锐. 罗格列酮对间歇性低氧小鼠氧化应激及认知功能的作用研究[J]. 山东大学耳鼻喉眼学报, 2017, 31(1): 45-49.
[3] 李兰根, 伟伟, 张玉凤, 格日乐图, 杨佳, 张艳梅. SIRT1抗视网膜色素上皮细胞氧化应激作用的实验研究[J]. 山东大学耳鼻喉眼学报, 2015, 29(6): 56-59.
[4] 梅栩彬, 邹新博, 赵立民, 邹慧中, 陈正岗, 刘文君. 阻塞性睡眠呼吸暂停综合征慢性低氧与非酒精性脂肪肝的相关性[J]. 山东大学耳鼻喉眼学报, 2015, 29(5): 11-13.
[5] 毕宏生,李树杰,崔 彦,王 慧 . 茶多酚防治STZ诱导的大鼠糖尿病性白内障的机制[J]. 山东大学耳鼻喉眼学报, 2008, 22(1): 1-05 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 赵利敏，倪坤，吴佳丽，陈淑梅，李晓艳. 婴幼儿吸气性喉喘鸣病因分析与治疗[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 49 -51 .
[2] 史春生1，张庆泉2,王强2,孙岩2,葛长艺1. 软腭缺损修复组织瓣的特点[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 86 -88 .
[3] 张令1,孙传义1,许安廷2. 以耳聋就诊的岩尖胆脂瘤1例[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 93 -94 .
[4] 吴彦桥，邸斌，李军，高晓红 . 鼻内镜下难治性鼻出血出血点寻找及止血策略[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 1 -3 .
[5] 罗惠秀，范春涛，邓延华. 阻塞性睡眠呼吸暂停低通气综合征患儿扁桃体腺样体切除术临床疗效分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 17 -20 .
[6] 郝颖娟1，杨庆松2，周跃华2，易省平1，翟长斌2. 飞秒激光在薄瓣LASIK手术中制作的角膜瓣厚度形态观察[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 26 -31 .
[7] 闻华明1，李海祥2. 应用三角函数法估算LASIK术后人工晶状体度数[J]. 山东大学耳鼻喉眼学报, 2013, 27(5): 74 -76 .
[8] 朱见，贺青卿，郑鲁明，范子义，赵国伟，侯蕾，史后彬 . cN0甲状腺微小乳头状癌淋巴结转移高危因素及行预防性清扫临床分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(6): 9 -12 .
[9] 李少华，孙一帆，卢标清. 双软组织血管瓣填塞乳突术腔的临床研究[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 6 -7 .
[10] 魏希建1，阴瑞兰2，郭星3. 增殖诱导配体在喉鳞状细胞癌中的表达[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 14 -16 .
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发