山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (5): 21-23.doi: 10.6040/j.issn.1673-3770.0.2016.413

• 睡眠呼吸障碍性疾病 • 上一篇    下一篇

阻塞性睡眠呼吸暂停低通气综合征患者血脂代谢与颈动脉内膜斑块形成的相关性

刘雅璇1,高西美2,徐萍2,王岩1,李延忠1   

  1. 山东大学 1.齐鲁医院耳鼻咽喉头颈外科/卫生部耳鼻喉科学重点实验室;
    2.健康体检中心, 山东 济南 250012
  • 收稿日期:2016-09-23 出版日期:2016-10-20 发布日期:2016-10-20
  • 通讯作者: 李延忠. E-mail:liyanzhong@sdu.edu.cn E-mail:343373839@qq.co
  • 作者简介:刘雅璇. E-mail:343373839@qq.co
  • 基金资助:
    国家自然科学基金(81170903)

Lipid metabolism and plaque development of carotid artery in patients with obstructive sleep apnea-hypopnea syndrome.

LIU Yaxuan1, GAO Ximei2, XU Ping2, WANG Yan1, LI Yanzhong   

  1. 1. Department of Otorhinolaryngology Head and Neck Surgery, Key Laboratory of Otolaryngology of Head Ministry;2. Department of Physical Examination Center, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2016-09-23 Online:2016-10-20 Published:2016-10-20

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摘要： 目的 探讨阻塞性睡眠呼吸暂停低通气综合症(OSAHS)患者血脂代谢及颈动脉内膜斑块形成情况。 方法 选取经多导睡眠监测诊断为OSAHS的男性患者99例为OSAHS组,并按睡眠呼吸暂停低通气指数(AHI)分为轻中度组(10例)、重度组(34例)和极重度组(55例),同时选取健康查体人员48例为对照组,受试者均采取空腹血测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,所有OSAHS患者均行颈动脉彩超检查并比较不同程度OSAHS患者颈动脉内膜斑块发生率的差异性。 结果 结果与对照组相比,各OSAHS组BMI均升高,HDL-C均降低,差异均有统计学意义(P<0.05),重度和极重度OSAHS组TG较对照组均升高(P<0.05),TC及LDL-C的差异无统计学意义(P>0.05)。相关性分析提示:OSAHS患者的IMT与AHI呈正相关(r=0.32, P=0.001),与平均SpO2呈负相关(r=-0.233, P=0.02),与最低SpO2无明显相关(r=-0.168, P=0.096)。极重度OSAHS患者的斑块发生率分别高于轻中度患者和重度患者,差异均有统计学意义(P<0.05)。 结论 OSAHS可能影响患者的血脂代谢及颈动脉内膜斑块的发生,极重度OSAHS患者颈动脉内膜斑块的发生率明显升高。

关键词: 睡眠呼吸暂停,阻塞性, 颈动脉内膜斑块, 脂质代谢

Abstract: Objective To explore the lipid metabolism disorder and plaque development of carotid artery in obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods A total of 99 OSAHS patients diagnosed by polysomnogram(PSG)were divided into the mild-moderate group(n=10), the severe group(n=34),and the profound group(n=55)according to the apnea-hypopnea index(AHI), and 48 healthy people severed as controls. Peripheral blood was collected from every individual after fasting. Blood lipid indexes including total cholesterol(TC), plasma triglycerides(TG), high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were measured. All patients in the OSAHS group underwent color Doppler ultrasonography of cervical artery. The intima-media thickness(IMT)and carotid plaques were recorded. Results Compared with the control group, BMI in different severity OSAHS groups were higher(P<0.05), the level of HDL-C was lower(P<0.01), the level of TG in severe and profound OSASH groups was higher(P<0.05), but the levels of TC and LDL-C had no significant differences(P>0.05). In the OSAHS groups, the IMT was positively correlated with AHI(P<0.05), but negatively correlated with mean SpO2(P>0.05). There was no significant correlation between AHI and minimum SpO2(P>0.05). There were significant differences in the incidence rate of carotid artery plaque among profound and other two OSAHS groups(P<0.05). Conclusion Abnormity of blood lipid metabolism existed in OSAHS patients, meanwhile, the incidence of carotid artery plaque of profound OSAHS patients increased more significantly.

Key words: Carotid artery plaque, Sleep apnea-hypopneasyndrome, obstructive, Lipid metabolism

中图分类号: 

  • R766
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[1] 李延忠. 肥胖与阻塞性睡眠呼吸暂停[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 1-4.
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