山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (6): 1-4.doi: 10.6040/j.issn.1673-3770.0.2016.062

• 论著 •    下一篇

突发性聋患者血脂分析

刘阳云,张彩霞,江文,陈琼,常恩格,赵花香,杨会   

  1. 湖南师范大学医学院第二附属医院/解放军第163中心医院耳鼻喉科, 湖南 长沙 410003
  • 收稿日期:2016-02-20 出版日期:2016-12-16 发布日期:2016-12-16
  • 作者简介:刘阳云. E-mail:879418362@qq.com

Analysis of blood lipids in patients with sudden sensorineural hearing loss.

LIU Yangyun, ZHANG Caixia, JIANG Wen, CHEN Qiong, CHANG Enge, ZHAO Huaxiang, YAN Hui   

  1. Department of Otolaryngology, Second Affiliated Hospital of Medical College of Hunan Normal University / No.163 Hospital of PLA, Changsha 410003, Hunan, China
  • Received:2016-02-20 Online:2016-12-16 Published:2016-12-16

摘要: 目的 研究血脂与突发性聋(突聋)发病的相关性,为血脂某些指标较高的人群提供预防措施,降低突聋发病率。 方法 检测68例突聋患者(突聋组)及同期住院的80例非突聋患者(对照组)血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、载脂蛋白a(Apo-A)和载脂蛋白β(Apo-β)的水平,统计分析两组间各血脂指标的差异。 结果 突聋组与对照组间甘油三酯(TG)差异有统计学意义(P<0.05),其余各指标差异无统计学意义(P>0.05);不同听力学曲线及不同听力下降程度的患者之间血脂各指标差异无统计学意义(P>0.05)。 结论 血脂中TG升高与突发性聋的发病有一定的关系,控制TG对预防突聋的发生可能有一定的意义。

关键词: 突发性聋, 甘油三酯, 血脂, 预防

Abstract: Objective To explore the correlation between blood lipids and sudden sensorineural hearing loss(SSHL), in order to provide preventive measures. Methods A total of 68 SSHL cases(SSHL group)and 80 non-SSHL cases(control group)were enrolled. The level of total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), apolipoprotein A(Apo-A)and apolipoprotein B(Apo-B)in the two groups of patients were measured and compared. Results There was statistical difference in the level of TG between the two groups(P<0.05), while there was no statistical difference in the other indicators(P>0.05). There was no statistical difference in the blood lipids between patients with different curves of audiology and patients with various degrees of hearing loss(P>0.05). Conclusion Increased TG level is related to the occurrence of the SSHL. Controlling the level of TG may help to prevent SSHL.

Key words: Blood lipid, Sudden sensorineural hearing loss, Prevention, Triglyceride

中图分类号: 

  • R764
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉头颈外科学分会. 突发性聋的诊断和治疗指南(2015)[J]. 中华耳鼻咽喉头颈外科杂志, 2015, 50(6): 443-447. Editorial Board of Chinese Journal of Otorhinolaryngology Head and neck surgery, Chinese Medical Association of Otorhinolaryngology, Head and Neck Surgery. Guideline of diagnosis and treatment of sudden deafness(2015)[J]. Chin J Otorhinolarynol Head Neck Surg, 2015, 50(6):443-447.
[2] Stachler R J, Chandrasekhar S S, Archer S M, et al. Clinical practice guideline:sudden hearing loss[J]. Otolaryngol Head Neck Surg, 2012, 146:S1- S35.
[3] Mohammed A A. Lipid profile among patients with sudden sensorineural hearing loss[J]. Indian J Otolaryngol Head Neck Surg, 2014, 66(4):425-428.
[4] 韩德民. 规范突发性聋的诊断与治疗[J]. 中国医学文摘(耳鼻咽喉科学), 2008, 23(1):1-2.
[5] 陈成芳, 王明明, 樊兆民, 等. 血脂与突发性聋发病及疗效的相关分析[J].中华耳鼻咽喉头颈外科杂志, 2015, 50(10):793-798. CHEN Chengfeng, WANG Mingming, FAN Zhaomin, et al. Correlations between the pathogenesis and prognosis of sudden sensorineural hearing loss and blood lipid[J]. Chin J Otorhinolarynol Head Neck Surg, 2015, 50(10):793-798.
[6] Oiticica J, Bittar R S. Metabolic disorders prevalence in sudden deafness[J]. Clinics, 2010, 65(11):1149-1153.
[7] Simpson A N, Matthews L J, Dubno J R. Lipid and C-reactive protein levels as risk factors for hearing loss in older adults[J]. Otolaryngol Head Neck Surg, 2013, 148(4):664-670.
[8] 徐宏鸣, 翁婷雯, 董频.突发感音神经性聋同血脂异常关系的研究进展[J].中华耳科学杂志, 2013, 11(3):461-463. XU Hongming, WENG Tingwen, DONG Pin. Research progress of the correlation on idiopathic sensorineural sudden hearing loss and blood lipid metabolism abnormalities[J]. Chin J Otology, 2013, 11(3):461-463.
[9] Rudack C, Langer C, Stoll W, et al. Vascular risk factors in sudden hearing loss[J]. Thromb Haemost, 2006, 95(3):454-461.
[10] 鲍凤香, 张燕平, 刘伟伟. 突发性聋与血脂代谢异常和血浆纤维蛋白原增高的相关性分析[J]. 听力学及言语疾病杂志, 2015, 23(2):156-159. BAO Fengxiang, ZHANG Yanping, LIU Weiwei. The correlation analysis between serum lipid metabolism abnormalities and increased plasma fibrinogen of sudden hearing loss[J]. J Audiol Speech Pathol, 2015, 23(2):156-159.
[11] Thakur J S, Mohindroo N K, Vasanthalakshmi M S, et al. Auditory brainstem evoked responses in hyperlipidaemia: effect of various lipid fractions on auditory function[J]. J Laryngol Otol, 2012, 126(3):249-256.
[12] Feron O, Dessy C, Desager J P, et al. Hydroxy-methylglutarylcoenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance[J]. Circulation, 2001, 103(1):113-118.
[13] Rossenbach J, Mueller G A, Lange K, et al. Lipid apheresis improves microcirculation of the upper limbs[J]. J Clin Apher, 2011, 26(4):167-173.
[14] Watt J, Kennedy S, Ahmed N, et al. The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD[J]. Open Heart, 2016, 28, 3(1):e000342.
[15] Stokes K Y. Microvascular responses to hypercholesterolemia: the interactions between innate and adaptive immune responses[J]. Antioxid Redox Signal, 2006, 8(7-8):1141-1151.
[16] Millán J, Pintó X, Muñoz A, et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention[J]. Vasc Health Risk Manag, 2009, 5:757-765.
[17] Sokup A, Góralczyk B, Góralczyk K, et al. Triglycerides as an early pathophysiological marker of endothelial dysfunction in nondiabetic women with a previous history of gestational diabetes[J]. Acta Obstet Gynecol Scand, 2012, 91(2):182-188.
[1] 李致富,高玉. 玻璃体切除术后视野缺损的机制研究及预防[J]. 山东大学耳鼻喉眼学报, 2025, 39(3): 168-176.
[2] 陈利群,沙玛丽·哈力木别克,王静,王富江,易湘龙. 数码视疲劳的眼表参数变化及预防缓解措施[J]. 山东大学耳鼻喉眼学报, 2025, 39(3): 177-182.
[3] 王鑫,原晶晶,郝鹏鹏,闫占峰,刘建华,钟利群,刘思溟,吴薇,赵晓阳,张莹. 中药复方治疗突发性聋的疗效和可能机制:一项结合网络药理学研究的回顾性临床分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 6-17.
[4] 郭翔,马永强,伊海金. 突发性聋磁共振检查的现状与进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 140-144.
[5] 李培培,卢彦青,侯楠. 机器学习预测模型在突发性聋中的临床应用研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 145-151.
[6] 陈丹萍,何子键,虞幼军,周晓娓. 儿童突发性聋10年住院病例的疗效及预后相关因素分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 16-22.
[7] 朱慧涛,陈丽倩,陶艳丽. 扁桃体术后口干发生机制及防治研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 131-135.
[8] 梁俊杰,张佳佳,张琳婧,孟言,李阳,白鹏. 中西医结合治疗突发性聋合并手足口病1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 91-95.
[9] 张佳佳,石安妮,邢御,洪玉颖,白鹏. 针刺联合西药治疗全聋型突发性聋1例与文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 88-92.
[10] 董淋,温思露,邓玉琴,陶泽璋. 他汀类药物在过敏性疾病中的治疗作用探讨[J]. 山东大学耳鼻喉眼学报, 2024, 38(1): 106-114.
[11] 于竺君,宁云红,谭智敏. 饮食对变应性疾病的影响[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 206-214.
[12] 艾自琴,李军政. 免疫疫苗在头颈部鳞状细胞癌中的研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(2): 143-150.
[13] 杨晰珺,关建,吴海莺. 阻塞性睡眠呼吸暂停低通气综合征与血脂紊乱关系的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 133-138.
[14] 谭玉芳,易天华. 鼻咽癌放疗后突发性聋18例[J]. 山东大学耳鼻喉眼学报, 2021, 35(1): 35-39.
[15] 梁慧敏,汪李琴,万文锦, 施赛磊,袁静,沈宇杰,张佳程,毛泽凡,倪璟滋, 潘奕文,陈智斌,程雷. 耳鼻咽喉科内镜室新型冠状病毒感染防控方案的探讨与实践[J]. 山东大学耳鼻喉眼学报, 2020, 34(2): 88-92.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!