山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (6): 22-23.doi: 10.6040/j.issn.1673-3770.0.2016.178

• 论著 • 上一篇    下一篇

碳酸氢钠联合氟康唑注射液治疗真菌性外耳道炎35例

沈莉   

  1. 溧阳市中医医院耳鼻喉科, 江苏 溧阳 213300
  • 收稿日期:2016-04-21 出版日期:2016-12-16 发布日期:2016-12-16
  • 作者简介:沈莉. E-mail:shenli_pig@sohu.com

Efficacy of sodium bicarbonate and fluconazole in the treatment of fungal otitis externa.

SHEN Li   

  1. Department of Otolaryngology, Liyang Traditional Chinese Medicine Hospital, Liyang 213300, Jiangsu, China
  • Received:2016-04-21 Online:2016-12-16 Published:2016-12-16

摘要: 目的 探讨碳酸氢钠联合氟康唑注射液治疗真菌性外耳道炎的疗效。 方法 使用随机平行对照方法,将真菌性外耳道炎患者105例,分为治疗组(碳酸氢钠联合氟康唑注射液耳浴);对照一组(氟康唑注射液耳浴);对照二组(2%水杨酸酒精耳浴),每组35例,连用10 d为一疗程,随访一年观察疗效。 结果 3个组的总有效率分别为91.43%、85.71%、77.14%,治疗组疗效优于2个对照组(P<0.05)。 结论 碳酸氢钠联合氟康唑注射液治疗真菌性外耳道炎的疗效优于单独采用氟康唑注射液或2%水杨酸酒精。

关键词: 碳酸氢钠, 氟康唑, 水杨酸, 真菌性外耳道炎

Abstract: Objective To explore the clinical efficacy of sodium bicarbonate combined with fluconazole in the treatment of fungal otitis externa. Methods Using random parallel control method, 105 patients with fungal otitis externa were divided into three groups: the treatment group(ear bath with sodium bicarbonate plus fluconazole injection); control group 1(ear bath with fluconazole injection); control group 2(ear bath with 2% salicylic acid alcohol), with 35 cases in each group. The treatment lasted for 10 days. The patients were followed up for one year to observe the curative effect. Results The total effective rate of the 3 groups were 91.43%, 85.71%, and 77.14%. The efficacy of the treatment group was better than that of the control groups(P<0.05). Conclusion Sodium bicarbonate combined with fluconazole is better than 2% salicylic acid alcohol or fluconazole alone in the treatment of fungal otitis externa.

Key words: Fluconazole, Salicylic acid, Sodium bicarbonate, Fungal otitis externa

中图分类号: 

  • R763
[1] 尹世芬. 外耳道真菌病三种抗真菌药物治疗的效果观察[J]. 齐齐哈尔医学院学报, 2012, 33(8):1005-1006. YIN Shifen. Observation on clinical application of three kinds of anti-fungis on fungi disease of outer ears[J]. J Qiqihar Med Univ, 2012, 33(8):1005-1006.
[2] Jia X, Liang Q, Chi F, et al. Otomycosis in Shanghai: aetiology, clinical features and therapy[J]. Mycoses, 2012, 55(5):404-409.
[3] 吴小飞. 氟康唑氯化钠注射液外用于外耳道治疗真菌性外耳道炎的可行性及安全性[J]. 社区医学杂志, 2012, 10(22):6-7. WU Xiaofei. Feasibility and safety of external application of fluconazole and sodium chloride injection for fungal otitis externa[J]. J Community Med, 2012, 10(22):6-7.
[4] 舒畅, 吴庆莲, 吴雯. 氟康唑注射液灌洗法治疗真菌性外耳道炎73例[J]. 中国伤残医学, 2011, 19(9):57. SHU Chang, WU Qinglian, WU Wen. Fluconazole injection irrigation treatment for 73 cases of fungal otitis externa[J]. Chin J Traumaz Disability Med, 2011, 19(9):57.
[5] 白素萍. 碱性溶液耳浴加微波照射治疗真菌性外耳道炎的观察与护理[J]. 全科护理, 2010, 8(5):377-378. BAI Suping. Observation and nursing care of patients with external auditory canal otomycosis treated with alkaline solution ear bath and microwave irradiation[J]. Chin General Nursing, 2010, 8(5):377-378.
[1] 许丽平. 碳酸氢钠溶液漱口联合制霉菌素混悬液雾化吸入治疗真菌性咽喉炎32例[J]. 山东大学耳鼻喉眼学报, 2017, 31(2): 121-122.
[2] 朱江彬, 孙秀芹, 南兵卫, 郝宗生. 5%碳酸氢钠液与制霉菌素片混合制剂纱条治疗真菌性外耳道炎156例[J]. 山东大学耳鼻喉眼学报, 2015, 29(6): 82-83.
[3] 黄雄超, 廖首本, 董仕婷, 钟海建, 覃永前. 氟康唑注射液耳浴治疗真菌性外耳道炎71例[J]. 山东大学耳鼻喉眼学报, 2015, 29(3): 29-30.
[4] 杨琨, 吴莎, 华清泉. 长期注射水杨酸钠对大鼠下丘GAD67和GABAAα1、c-fos表达的影响[J]. 山东大学耳鼻喉眼学报, 2015, 29(1): 24-27.
[5] 帅少帅, 何夏怡, 宁红珠, 罗友琼, 梁斯敏. 角膜基质层注射治疗真菌性角膜炎[J]. 山东大学耳鼻喉眼学报, 2014, 28(5): 76-78.
[6] 刘春青,刘海成,侯峥. 耳内镜下治疗真菌性外耳道炎77例[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 51-52.
[7] 魏婷婷1,赵德安1,高兴强1,苏文玲1,朱艳双1,赵岩2. Arc/arg3.1基因在耳鸣大鼠模型听觉脑干中的表达情况[J]. 山东大学耳鼻喉眼学报, 2010, 24(01): 21-24.
[8] 凡启军,黄治物,梅 玲,肖伯奎 . 荧光定量PCR测定水杨酸钠作用后大鼠耳蜗基因的表达[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 212-214 .
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 赵利敏,倪坤,吴佳丽,陈淑梅,李晓艳. 婴幼儿吸气性喉喘鸣病因分析与治疗[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 49 -51 .
[2] 史春生1,张庆泉2,王强2,孙岩2,葛长艺1. 软腭缺损修复组织瓣的特点[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 86 -88 .
[3] 张令1,孙传义1,许安廷2. 以耳聋就诊的岩尖胆脂瘤1例[J]. 山东大学耳鼻喉眼学报, 2013, 27(2): 93 -94 .
[4] 吴彦桥,邸斌,李军,高晓红 . 鼻内镜下难治性鼻出血出血点寻找及止血策略[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 1 -3 .
[5] 罗惠秀,范春涛,邓延华. 阻塞性睡眠呼吸暂停低通气综合征患儿扁桃体腺样体切除术临床疗效分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 17 -20 .
[6] 郝颖娟1,杨庆松2,周跃华2,易省平1,翟长斌2. 飞秒激光在薄瓣LASIK手术中制作的角膜瓣厚度形态观察[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 26 -31 .
[7] 闻华明1,李海祥2. 应用三角函数法估算LASIK术后人工晶状体度数[J]. 山东大学耳鼻喉眼学报, 2013, 27(5): 74 -76 .
[8] 朱见,贺青卿,郑鲁明,范子义,赵国伟,侯蕾,史后彬 . cN0甲状腺微小乳头状癌淋巴结转移高危因素及行预防性清扫临床分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(6): 9 -12 .
[9] 李少华,孙一帆,卢标清. 双软组织血管瓣填塞乳突术腔的临床研究[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 6 -7 .
[10] 魏希建1,阴瑞兰2,郭星3. 增殖诱导配体在喉鳞状细胞癌中的表达[J]. 山东大学耳鼻喉眼学报, 2014, 28(1): 14 -16 .