山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (1): 21-26.doi: 10.6040/j.issn.1673-3770.0.2016.507

• 论著 • 上一篇    下一篇

阻塞性睡眠呼吸暂停低通气综合征儿童中血清维生素D检测的意义

刘婷,王岩,李延忠   

  1. 山东大学齐鲁医院耳鼻咽喉科/卫生部耳鼻喉科学重点实验室, 山东 济南 250012
  • 收稿日期:2016-12-09 出版日期:2017-02-16 发布日期:2017-02-16
  • 通讯作者: 李延忠. E-mail:liyanzhong@sdu.edu.cn
  • 基金资助:
    国家自然科学基金(81170903)

Relationship between vitamin D and obstructive sleep apnea hypopnea syndrome in children.

  1. Department of Otorhinolaryngology, Key Laboratory of Otolaryngology of Head Ministry, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2016-12-09 Online:2017-02-16 Published:2017-02-16

摘要: 目的 探讨血清维生素D检测对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)儿童的临床意义。 方法 选择因打鼾症状于山东大学齐鲁医院耳鼻咽喉科治疗的儿童69例作为实验组,70例健康儿童作为对照组,化学发光免疫测定法检测139例儿童的外周血清25(OH)D水平。有打鼾症状儿童69例根据睡眠监测结果将其分为OSAHS组(47例),单纯鼾症组(22例),69例儿童采取空腹血测定血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,并采用Conners 父母症状问卷从品行问题、学习问题、心身障碍、焦虑、冲动-多动、多动指数方面评估两组儿童行为认知异常。 结果 (1) 对照组与单纯鼾症组、OSAHS组研究对象血清25(OH)D水平分别为(25.38±10.87)、(22.00±7.84)、(17.92±6.32)ng/mL,差异有统计学意义(F=9.458, P<0.001);OSAHS组25(OH)D水平低于对照组,差异有统计学意义(P<0.001),单纯鼾症组25(OH)D水平与对照组及OSAHS组差异均无统计学意义(P值均>0.05);(2) 肥胖(-)儿童中,OSA(+)儿童25(OH)D水平明显低于OSA(-)儿童,差异有统计学意义(P=0.001)。OSA(+)儿童中,肥胖(+)儿童与肥胖(-)儿童25(OH)D水平差异无统计学意义(P=0.566); (3) OSAHS组25(OH)D水平与焦虑呈正相关(r=0.337, P=0.020),与最低血氧饱和度(LSaO2)、低通气指数(AHI)、品行问题、学习问题、心身障碍、冲动-多动、多动指数、TG、TC、HDL-C、LDL-C无明显相关性(r值均<0.5, P值均>0.05)。 结论 25(OH)D在OSAHS儿童体内降低,对进一步了解OSAHS儿童的病理生理改变有一定的临床意义。

关键词: 睡眠呼吸暂停,阻塞性, 儿童, 维生素D

Abstract: Objective To investigate the clinical significance of detecting serum vitamin D level in children with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods During June and Octorber 2016, 69 children with snoring were divided into the OSAHS group(n=47)and primary snoring(PS)group(n=22)according to the apnea-hypopnea index(AHI), and 70 healthy children without snoring served as controls. Venous blood was drawn from each child to measure the serum level of 25(OH)D, triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C). Childrens behaviors were assessed with Conners Parent Symptom Questionnaire(PSQ). Results (1) The mean serum 25(OH)D level of the control, PS and OSAHS groups were 25.38±10.87 ng/mL, 22.00±7.84 ng/mL, and 17.92±6.32 ng/mL(F=9.458, P<0.001). There was significant difference between the OSAHS group and the control group(P<0.001), but no statistical difference between the PS group and the control group(P>0.05). (2) Non-obese children with OSA had significantly lower 25(OH)D level than non-obese children without OSA(P=0.001). There were no significant difference between obese children with OSA and non-obese children with OSA(P=0.566). (3) The 25(OH)D level of the OSAHS group showed positive correlation with anxiety(r=0.337, P=0.020), but no significant correlation with AHI, PSQ, TG, TC, HDL-C and LDL-C(r<0.5, P>0.05). Conclusion The level of serum 25(OH)D is significantly decreased in children with OSAHS, which may help to explore the pathophysiological changes of OSAHS.

Key words: Sleep apnea, obstructive, Vitamin D, Children

中图分类号: 

  • R766.7
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