山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (3): 60-63.doi: 10.6040/j.issn.1673-3770.0.2016.370

• 变应性鼻结膜炎防治进展·综述 • 上一篇    下一篇

变应性鼻炎中医证候动物模型的研究进展

李莉珠1,吴卿1,易欣1,田理2   

  1. 1.成都中医药大学, 四川 成都 610075;
    2.成都中医药大学附属医院, 四川 成都 610072
  • 收稿日期:2016-08-23 出版日期:2017-06-16 发布日期:2017-06-16
  • 通讯作者: 田理. E-mail:tiandr@gmail.com

Research progress on the animal model of allergic rhinitis in traditional Chinese medicine.

LI Lizhu1, WU Qing1, YI Xin1, TIAN Li2   

  1. 1. Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China;2. Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China
  • Received:2016-08-23 Online:2017-06-16 Published:2017-06-16

HTML

PDF (PC)

771

摘要： 变应性鼻炎(AR)是临床最常见的耳鼻喉科疾病之一。中医药对AR的研究和防治已进入细胞学、分子生物学水平,中医证候动物模型的建立是连接中医基础和临床的桥梁与纽带,建立能够较好地模拟具有中医证候的人类AR的动物模型有助于深入研究中医药防治该病的作用及其机制。

关键词: 动物模型, 中医证候, 变应性鼻炎

Abstract: Allergic rhinitis(AR)is one of the most common diseases of the otolaryngological department. The research on prevention and treatment of Traditional Chinese Medicine(TCM)function on AR had reached the stage of cytology as well as molecular.The establishment of syndrome differentiated animal model can enhance the connection between TCM basis and clinic. To establish an animal model which can reflect syndrome differentiation of human AR contributes to deeper study of function mechanism of prevention and treatment of TCM on AR.

Key words: Animal model, Syndrome of traditional Chinese medicine, Allergic rhinitis

中图分类号: 

  • R765.21
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 变应性鼻炎诊断和治疗指南(2015年,天津)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(1):6-24. Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. Chinese guidelines for diagnosis and treatment of allergic rhinitis[J]. Chin J Otorhinolaryngol Head Neck Surg, 2016, 51(1):6-24.
[2] Reed SD, Lee TA, Mc Crory DC. The economic burden of allergic rhinitis: a criticle evaluation of the literature[J]. Pharmacoeccnmics, 2004, 22(3):345-361.
[3] 王世贞,谢立平.卫气虚与变应性鼻炎相关性的初步试验研究[J].中国中西医结合耳鼻咽喉科杂志,1995,3(1):4-7.
[4] Tanaka K, Okamoto Y, Nagaya Y, et al. Anasal allergy model devel-oped in the guinea pig by intranasal application of 2,4-toluene di-Isocyanate[J]. Int Areh Allergy Appl Immunol, 1988, 85(4):392-397.
[5] 陈炯垣,赖月,李冬日,等.混合人血清诱发豚鼠过敏反应死亡模型的改良[J].法医学杂志,2012,28(6):408-412.
[6] 张永靖.变应性鼻炎动物模型造模综述[J].内蒙古医学杂志,2014,46(6):693-696.
[7] 冯纬云.变应性鼻炎动物模型造模综述[J].广西中医学院学报,2009,12(2):77-79.
[8] 李萌,魏肖云,汪受传,等.变应性鼻炎动物模型的研究现状[J].现代中西医结合杂志,2013,22(12):1360-1363.
[9] 陈小野.实用中医证候动物模型学[M].北京:北京医科大学、中国协和医科大学联合出版社,1993:110.
[10] 陈宇,唐月英,周美玲,等.益气固表法治疗肺气虚型变应性鼻炎的研究[J].中华中医药杂志,2015,30(9):3337-3340. CHEN Yu, TANG Yueying, ZHOU Meiling, et al. Effects of tonifying qi and strengthening exterior on treatment of allergic rhinitis rats with lung qi deficiency syndrome[J]. Chin J Trad Chin Med Pharmacy, 2015, 30(9):3337-3340.
[11] 邓婧,彭成,彭顺林,等.鼻敏颗粒对肺气虚型变应性鼻炎大鼠血清IL-4 IL-10水平的影响[J].四川中医,2014,32(8):59-61. DENG Jing, PENG Cheng, PENG Shunlin, et al. Effects of Bimin Granules on serum IL-4 and IL-10 levels of lung-qi-deficiency rats with allergic rhinitis[J]. J Sichuan Trad Chin Med, 2014, 32(8):59-61.
[12] 刘瑶,彭顺林,尹红,等.芪龙颗粒对肺气虚型变应性鼻炎大鼠血清 IL-1 和 IL-4 水平的影响[J].中国实验方剂学杂志,2012,18(14):224-226. LIU Yao, PENG Shunlin, YIN Hong, et al. Influence of Qilong Granula on IL-1 and IL-4 in serum in allergic rhinitis rats with lung-qi-deficiency[J]. Chin J Exp Trad Med Formulae, 2012, 18(14):224-226.
[13] 卢健敏.温肺止流丹对肺气虚变应性鼻炎模型大鼠鼻黏膜组织IL-4mRNA 表达和血清IL-4的影响[J].陕西中医学院学报,2013,36(3):95-96.
[14] 席斌,田道法.变应性鼻炎肺气虚证与血清IL-4和IFN-γ相关性的实验研究[J].中国中西医结合耳鼻咽喉科杂志,2007,15(3):166-170. XI Bin, TIAN Daofa. Experimental study on the association of serum levels of IL-4 and IFN-r with the development of allergic rhinitis in the pattern of Lung Qi deficiency among guinea pigs[J]. Chin Otorhinolaryngol J Integ Med, 2007, 15(3):166-170.
[15] 邱宝珊,刘蓬,黄可儿,等.补中益气汤对脾虚型变应性鼻炎的治疗作用[J].中药新药与临床药理,2003,14(3):147-149. QIU Baoshan, LIU Peng, HUANG Keer, et al. Effect of BuzhongYiqi Decoction for allergic rhinitis with spleen-qi deficiency in guinea pigs[J]. Trad Chin Drug Res Clin Pharmacol, 2003, 14(3):147-149.
[16] 王宇,严道南.脾气虚与变应性鼻炎模型大鼠相关机理的研究[J].南京中医药大学学报,2011,27(2):140-143. WANG Yu, YAN Daonan. Related mechanism between spleen-qi deficiency and allergic rhinitis in rats[J]. J Nanjing TCM Univ, 2011, 27(2):140-143.
[17] 付文祥,谢慧,熊大经,等.脾虚型AR大鼠鼻黏膜白介素mRNA的活性表达[J].中华中医药学刊,2010,28(12):2486-2488. FU Wenxiang, XIE Hui, XIONG Dajing, et al. Activity expression of interleuk in mRNA in nasal mucosa of rats with spleen deficiency type AR[J]. Chin Arch Trad Chin Med, 2010, 28(12):2486-2488.
[18] 李瑛.摄鼽止氯汤对肾阳虚型变应性鼻炎大鼠血清细胞因子IL-5、ECP的影响[D].成都:成都中医药大学,2012.
[19] 阮岩,杨占军,陈蔚,等.温肾补阳法对肾阳虚变应性鼻炎大鼠模型血清Th1/Th2细胞因子表达的影响[J].中药新药与临床药理,2006,17(1):29-31. RUAN Yan, YANG Zhanjun, CHEN Wei, et al. Influence of kidney-yang warming therapy on expression of Th1/Th2 cytokines in rats with allergic rhinitis[J]. Trad Chin Drug Res Clin Pharmacol, 2006, 17(1):29-31.
[20] 贺敏.阳和汤对肾阳虚变应性鼻炎大鼠鼻黏膜ICAM-1,VCAM-1表达的影响[D].成都:成都中医药大学,2008.
[21] 徐慧贤,阮岩,王世贞,等.豚鼠肾阳虚变应性鼻炎模型的建立[J].中药新药与临床药理,2005,16(6):427-429. XU Huixian, RUAN Yan, WANG Shizhen, et al. Establishment of guinea pig models of allergic rhinitis with kidney-yang deficiency[J]. Trad Chin Drug Res Clin Pharmacol, 2005, 16(6):427-429.
[22] 钟筱华,张海丹.肾阳虚变应性鼻炎动物模型的研究[J].中国中医药现代远程教育,2010,8(4):168-170. ZHONG Xiaohua, ZHANG Haidan. Adenine deficiency produced an animal model of allergic rhinitis development[J]. Chin Med Modern Dist Edu Chin, 2010, 8(4):168-170.
[23] 赵秀杰,董霞,杨占泉,等.鼻超敏反应实验模型的建立[J].中华耳鼻咽喉科杂志,1993,28(1):17-18.
[1] 王坛,武珂,李连庆,宫丽丽. 皮下免疫治疗注射后出现全身不良反应的伴发因素及处理[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 71-74.
[2] 卢汉桂,林歆胜,姚丹勉,魏永新,李创伟. 变应性鼻炎大鼠IL-35的表达及对辅助性T细胞免疫调节的影响[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 66-70.
[3] 浦洪波,杜晓东. 无锡地区2 000例变应性鼻炎变应原检测结果分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 105-107.
[4] 陈鸣,俞雪飞. 浅谈伴有变应性鼻炎的慢性鼻窦炎的治疗[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 18-22.
[5] 吴湘萍. 患者管理方式对变应性鼻炎舌下含服粉尘螨滴剂疗效的影响[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 68-72.
[6] 李松,王宗贵,杨景朴,张竹萍. 鼻内镜下翼管神经切断术进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(1): 72-76.
[7] 郅莉莉,宋道亮. 嗜酸性粒细胞及IL5在上颌窦后鼻孔息肉与鼻息肉中表达的差异[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 43-46.
[8] 万文锦,王文,程雷. 尘螨变应性鼻炎皮下免疫治疗与舌下免疫治疗的荟萃分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 103-108.
[9] 胡锦东,刘新泉. 干眼动物模型研究进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 109-113.
[10] 朱新华. 变应性鼻炎冲击免疫治疗的临床应用[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 13-17.
[11] 史丽,赵莉,张红萍. 变应性鼻炎的长期抗炎治疗[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 9-12.
[12] 刘静. 基于整体观念变应性鼻炎的中医辨证论治[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 28-30.
[13] 程雷,钱俊俊,田慧琴. 变应性鼻炎研究的若干进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 1-3.
[14] 许昱,陶泽璋. 重视变应性鼻炎药物治疗的规范化和个体化[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 4-8.
[15] 刘英,叶小静,赵春丽,季青,黄谦. 季节性变应性鼻炎预防性治疗观察[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 37-40.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 李兆生,洪燕丽,许振跃,洪 斌,陈瑞坤 . 复杂气管、支气管异物4例并文献复习[J]. 山东大学耳鼻喉眼学报, 2008, 22(2): 176 -179 .
[2] 王春雨,张芬,张庆泉,王永福,王艳,柳忠禄,康莎莎,赵元阳,王贝贝,李志云. 鼻内镜下经鼻内进路行腭正中囊肿微创手术21例临床分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 84 -86 .
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发