IVR联合PDT治疗湿性年龄相关性黄斑变性的临床观察

doi:10.6040/j.issn.1673-3770.0.2016.227

摘要/Abstract

摘要： 目的观察雷珠单抗联合光动力疗法治疗湿性年龄相关性黄斑变性(wAMD)的长期有效性及安全性。方法回顾分析wAMD患者11例(11眼),均在初始接受了玻璃体腔注射雷珠单抗0.5 mg后7 d内联合标准剂量的光动力疗法(PDT),并根据患者复诊情况行玻璃体腔注射雷珠单抗(IVR)再治疗或者观察。统计患者最佳矫正视力(BCVA)、中心视网膜厚度(CRT)、眼压(IOP)及IVR再治疗次数。结果治疗后第2、3、6个月患者BCVA较治疗前提高(P<0.05);治疗后第18个月患者BCVA较治疗前平均提高了(7.31±15.00)个字母,CRT较治疗前下降(P<0.05);IOP治疗前后无统计学差异;前18个月患者IVR再治疗平均次数为1.55次(0~8次)。结论 IVR联合PDT可降低wAMD临床干预次数并延长疗效。

关键词: 血管内皮生长因子, 光动力疗法, 湿性年龄相关性黄斑变性, 联合疗法

Abstract: Objective To investigate the potential long-term benefit of combination of intravitreal ranibizumab with photodynamic therapy for the treatment for wet age-related macular degeneration(wAMD). Methods A retrospective review was conducted on 11 eyes of 11 patients that received intravitreal ranibizumab(IVR)0.5 mg combined with standard photodynamic therapy(PDT)within 7 days, and thereafter retreatment as required with intravitreal ranibizumab monotherapy for at least 18 months. Collected data included: best-corrected visual acuity(BCVA), central retinal thickness(CRT), intraocular pressure(IOP)and number of retreatment. Results The mean BCVA was apparently improved from baseline at the 2nd, 3rd and 6th month of follow-up compared to baseline(P<0.05, showing improvement of 7.31±15.00 letters from baseline at eighteen months of follow-up. )Meanwhile, CRT decreased significantly compared with pre-treatment(P<0.05). During the treatment, IOP kept steady with no statistical difference between pre- and post-treatment.The study eyes received an average of 1.55 times(range: 0 to 8)of intravitreal anti-VEGF reagent injection during the total 18 months period after initial combination therapy. Conclusion Combination therapy could reduce times of intravitreal anit-VEGF reagent injection and maintaine long-lasting effect on wAMD.

Key words: Wet age-related macular degeneration, Vascular endothelial growth factor, Photodynamic therapy, Combination therapy

中图分类号:

R774

王翠,颜昕,赵博军. IVR联合PDT治疗湿性年龄相关性黄斑变性的临床观察[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 94-97.

WANG Cui, YAN Xin, ZHAO Bojun. Combination of intravitreal ranibizumab with photodynamic therapy in the treatment of wet age-related macular degeneration.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 94-97.

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