氧化应激与噪音性聋发病机制及治疗进展

doi:10.6040/j.issn.1673-3770.0.2017.185

山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (5): 101-103.doi: 10.6040/j.issn.1673-3770.0.2017.185

氧化应激与噪音性聋发病机制及治疗进展

张转,刘涛,白治丽,周长明

延安大学附属医院耳鼻喉科, 陕西延安 716000

收稿日期:2017-04-26 出版日期:2017-10-16 发布日期:2017-10-16
通讯作者: 刘涛. E-mail:hxlt002@163.com
基金资助:
陕西省科技技术研究发展项目(2013k14-02-27);延安市耳鼻咽喉头颈临床研究科技创新团队(2015CXTD-10);陕西省教育厅科学技术项目资助(2013JK0783)

Evolution of oxidative stress in the pathogenesis and treatment of noise-induced hearing loss.

ZHANG Zhuan, LIU Tao, BAI Zhili, ZHOU Changming

Department of Otorhinolaryngology, Affiliated Hospital of Yanan University, Yanan 716000, Shaanxi, China

Received:2017-04-26 Online:2017-10-16 Published:2017-10-16

摘要/Abstract

摘要： 噪音性聋属常见职业病,其致病机制的研究涉及组织、分子及基因等方面,衍生出机械学说、代谢学说、血管学说、钙离子平衡失调、神经因子缺乏及钾离子循环途径等学说。就氧化应激机制在噪音性聋发病中的作用及治疗进行综述。

关键词: 噪音性聋, 氧化应激, 活性氧

Abstract: Noise-induced hearing loss(NIHL)is a common professional disease. With the improvement in-depth study of recent advances in medicine. The pathogenesis of the disease has been studied from various aspects including the level of molecular and genetic organization, theory of machinery, metabolic theory, theory of blood vessels, imbalance of calcium ions, lack of nerve factors, potassium ion cycle, etc. This paper reviews the role of oxidative stress in the pathogenesis and treatment of NIHL.

Key words: Noise-induced hearing loss, Reactive oxygen species, Oxidative Stress

中图分类号:

R764.43

张转,刘涛,白治丽,周长明. 氧化应激与噪音性聋发病机制及治疗进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(5): 101-103.

ZHANG Zhuan, LIU Tao, BAI Zhili, ZHOU Changming. Evolution of oxidative stress in the pathogenesis and treatment of noise-induced hearing loss.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 101-103.

参考文献

[1] Hong O, Kerr MJ, Poling GL, et al. Understanding and preventing noise-induced hearing loss[J]. Dis Mon, 2013, 59(4):110-118.
[2] Yamashita D, Jiang HY, Schacht J, et al. Delayed production of free radicals following noise exposure[J]. Brain Res, 2004, 1019(1-2):201-209.
[3] 吴龙军, 黄益灯, 于宁,等. 依达拉奉对噪声性聋防治作用[J]. 中华耳科学杂志, 2014,12(1):142-146. WU Longjun, Huang Yideng, YU Ning, et al. Edaravone protects against noise-induced hearing loss[J]. Chin J Otol, 2014, 12(1): 142-146.
[4] Henderson D, Bielefeld EC, Harris KC, et al. The role of oxidative stress in noise-induced hearing loss[J]. Ear Hear, 2006, 27(1): 1-19.
[5] Valdez LB, Arnaiz SL, Bustamante J, et al. Free radical chem-istry in biological systems[J]. Biol Res, 2000, 33(2):65-70.
[6] Ohinata Y, Miller JR, Schacht J. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea[J]. Brain Res, 2000, 878(1-2):163-173.
[7] Bielefeld EC, Hu BH, Harris KC, et al. Damage and threshold shift resulting from cochlear exposure to Paraquat-generated superoxide[J]. Hear Res, 2005, 207(1-2):35-42.
[8] 孔维佳, 周梁. 耳鼻咽喉头颈外科:第三版[M]. 北京: 人民卫生出版社, 2015:683-654.
[9] Yang WP, Henderson D, Hu BH, et al. Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise[J]. Hear Res, 2004, 196(1-2):69-76.
[10] Beck MA. Selenium and host defence towards viruses[J]. Proc Nutr Soc, 1999, 58(3):707-711.
[11] 陈建雄, 李旭东, 罗杰明, 等. 噪声性听力损失易感人群外周血SOD1、SOD2、T-AOC及MDA水平分析[J]. 中国卫生工程学, 2012, 11(2):92-96. CHEN Jianxiong, LI Xudong, LUO Jieming, et al. Level analysis of SOD’T-AOC and MDA in noise-induced hearing loss susceptibility[J]. Chin J Public Health Eng, 2012, 11(2):92-96.
[12] Liu YM, Li XD, Guo X, et al. SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers[J]. Dis Markers, 2010, 28(3):137-147.
[13] Tuerdi A, Kinoshita M, Kamogashira T, et al. Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice[J]. Neurosci Lett, 2017, 642:123-128.
[14] Hight NG, McFadden SL, Henderson D, et al. Noise-induced hearingloss in chinchillas pre-treated with glutathione monoethylester andR-PIA[J]. Hear Res, 2003, 179(1-2):21-32.
[15] Kopke RD, Coleman JK, Liu J, et al. Candidates thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss[J]. Laryngoscope, 2002, 112(9):1515-1532.
[16] Usami S, Hjelle OP, Ottersen OP. Differential cellular distribution ofglutathione—an endogenous antioxidant—in the guinea pig innerear[J]. Brain Res, 1996, 743(1-2):337-340.
[17] Le Prell CG, Yamashita D, Minami SB, et al. Mechanisms of noise-induced hearing loss indicate multiple methods of prevention[J]. Hear Res, 2007, 226(1-2):22-43.
[18] Le Prell CG, Hughes LF, Miller JM. Free radical scavengers vitamins A,C,and E plus magnesium reduce noise trauma[J]. Free Radic Biol Med, 2007, 42(9):1454-1463
[19] 陈立伟. 饱和氢生理盐水对噪声性聋防护作用的分子病理机制研究[D]. 北京: 中国人民解放军医学院, 2014.
[20] Zhang JY, Liu C, Zhou L, et al. A review of hydrogen as a new medical therapy[J]. Hepato-gastroenterology, 2012, 59(116):1026.
[21] Hong Y, Chen S, Zhang JM. Hydrogen as a selective antioxidant:a review of clinical and experimental studies[J]. J Int MedRes, 2010, 38(6):1893-1903.
[22] Zhou Y, Zheng H, Ruan F, et al. Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs[J]. Neuroscience, 2012, 209:47-53.
[23] Asplund MS, Lidian A, Linder B, et al. Protective effect of edaravoneagainst tobramycin- induced ototoxicity[J]. Acta Oto- Laryngologica, 2009, 129(1):8-13.
[24] 高刚, 孙建军, 龚树生,等. 依达拉奉对豚鼠耳蜗急性声损伤的保护作用[J]. 中华耳鼻咽喉头颈外科杂志, 2009, 44(2):150-153. GAO Gang, SUN Jianjun, GONG Shusheng, et al. Edaravone protects hearing from acute acoustic trauma in guinea pigs[J]. Chin J Otorhinolaryngol Head Neck Surg, 2009, 44(2):150-153.
[25] Hong SJ, Im GJ, Chang J, et al. Protective effects of edaravoneagainst cisplatin-induced hair cell damage in zebrafish[J]. Int J Pediatr Otorhinolaryngol, 2013, 77(6):1025-1031.
[26] Tanaka K, Takemoto T, Sugahara K, et al. Post-exposure administration of edaravone attenuates noise-induced hearing loss[J]. Eur J Phar, 2005, 522(1-3):116-121.
[27] 卢燕, 于宁, 翟所强, 等. 内耳相关基础研究专辑饱和氢生理盐水对噪声性聋的预防作用[J]. 中华耳科学杂志, 2011, 9(3):276-280. LU Yan, YU Ning, ZHAI Suoqiang, et al. Saturated hydrogen saline protects against noise-induced hearing loss[J]. Chin J Otol, 2011, 9(3):276-280.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

氧化应激与噪音性聋发病机制及治疗进展

Evolution of oxidative stress in the pathogenesis and treatment of noise-induced hearing loss.

HTML

PDF (PC)

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

多维度评价

本文评价

推荐阅读 0

[1]	李小波,曹忠胜,辛洁,谢辰,陈锐. 罗格列酮对间歇性低氧小鼠氧化应激及认知功能的作用研究[J]. 山东大学耳鼻喉眼学报, 2017, 31(1): 45-49.
[2]	李延忠. 肥胖与阻塞性睡眠呼吸暂停[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 1-4.
[3]	李兰根, 伟伟, 张玉凤, 格日乐图, 杨佳, 张艳梅. SIRT1抗视网膜色素上皮细胞氧化应激作用的实验研究[J]. 山东大学耳鼻喉眼学报, 2015, 29(6): 56-59.
[4]	毕宏生,李树杰,崔彦,王慧 . 茶多酚防治STZ诱导的大鼠糖尿病性白内障的机制[J]. 山东大学耳鼻喉眼学报, 2008, 22(1): 1-05 .