山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (6): 29-32.doi: 10.6040/j.issn.1673-3770.1.2017.036

• 甲状腺癌的规范化诊断与治疗·论著 • 上一篇    下一篇

乙酰肝素酶和D2-40在儿童甲状腺癌中的表达及临床意义

潘永杰1,2,庞文会1,孙国臣1,孙彦1,张虹3   

  1. 1. 青岛大学附属医院耳鼻咽喉头颈外科, 山东 青岛 266003;
    2. 临沂市妇女儿童医院耳鼻咽喉头颈外科, 山东 临沂 276000;
    3. 青岛大学附属医院小儿外科, 山东 青岛 266003
  • 收稿日期:2017-10-09 出版日期:2017-12-16 发布日期:2017-12-16
  • 通讯作者: 庞文会. E-mail:pangwenhui2005@126.com
  • 基金资助:
    国家自然青年基金(81700889)

Expression and clinical significance of Heparanase and D2-40 in pediatric thyroid carcinoma.

PAN Yongjie1,2, PANG Wenhui1, SUN Guochen1, SUN Yan1, ZHANG Hong3   

  1. 1. Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China;2. Women and Childrens Hospital of Linyi, Linyi 276000, Shandong, China;3. Department of Pediatric Surgery, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China
  • Received:2017-10-09 Online:2017-12-16 Published:2017-12-16

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摘要： 目的 探讨乙酰肝素酶(Hpa)和D2-40在儿童甲状腺癌(年龄≤18岁)中的表达及临床意义。 方法 采用免疫组化SP法检测儿童甲状腺癌与成人甲状腺癌中Hpa和D2-40的表达情况。 结果 Hpa和D2-40在儿童甲状腺癌及成人甲状腺癌中均呈高表达,且两种蛋白在儿童甲状腺癌中的表达均与淋巴结转移程度密切相关,其中Hpa的表达还与肿瘤组织类型有关,但与年龄、性别和是否侵犯包膜无关。 结论 Hpa和D2-40在儿童甲状腺癌中高表达,且与淋巴结转移密切相关,因此可作为儿童甲状腺癌患者生物学特征的指标。

关键词: 乙酰肝素酶, 儿童, 甲状腺癌, D2-40

Abstract: Objective To analyze the expression and clinical significance of heparanase( Hpa)and D2-40 in pediatric thyroid carcinoma. Methods Immunohistochemical SP method was used to check the expression of Hpa and D2-40 in pediatric thyroid carcinoma and adult thyroid carcinoma. The expression of Hpa and D2-40 in thyroid carcinoma and its clinical significance were analyzed. Results Hpa and D2-40 were highly expressed in pediatric thyroid carcinoma and adult thyroid carcinoma. The expression of the two proteins in pediatric thyroid carcinoma and adult thyroid carcinoma were related to the degree of lymph node metastasis, but it has nothing to do with age,sex,tissue type and whether capsule invasion. Conclusion The Hpa and D2-40 in pediatric thyroid carcinoma and adult thyroid carcinoma were all highly expressed, and they ware closely related to the lymph node metastasis, so Hpa and D2-40 can be used as the biological characteristics index of pediatric thyroid carcinoma.

Key words: Heparanase, Child, Thyroid carcinoma, D2-40

中图分类号: 

  • R581
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