不同分型慢性鼻-鼻窦炎患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性分析

doi:10.6040/j.issn.1673-3770.0.2017.422

摘要/Abstract

摘要： 目的分析不同分型慢性鼻-鼻窦炎(CRS)患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性。方法前瞻性选取2015年5月至2017年5月间在上海市宝山区大场医院和上海中医药大学附属曙光医院宝山分院接受治疗的150例CRS患者,收集患者临床资料,皮肤点刺试验的结果及外周血内中性粒细胞和嗜酸性粒细胞所占比率,分析其与CRS起病联系情况。结果 150例患者手术后病理诊断显示45例为中性粒细胞型,105例为嗜酸性粒细胞型;嗜酸性粒细胞的浸润型患者外周血内嗜酸性粒细胞所占比率高于中性粒细胞的浸润型患者,差异有统计学意义(P<0.05);慢性鼻-鼻窦炎不伴鼻息肉(CRSsNP)、慢性鼻-鼻窦炎伴息肉(CRSwNP)分型和免疫病理的分型在两种不同浸润型患者内分布对比差异无统计学意义(P>0.05)。结论 CRS病理组织内中性粒细胞和嗜酸性粒细胞的浸润程度与其外周血内嗜酸性粒细胞所占比率有关,局部嗜酸性粒细胞和外周血内嗜酸性粒细胞的浸润程度呈现为一致性。

关键词: 鼻-鼻窦炎, 慢性, 鼻息肉, 嗜酸性粒细胞, 中性粒细胞

Abstract: Objective To analyze the percentage of eosinophils and neutrophils in the blood of patients with chronic rhinosinusitis(CRS)and clinical differences in allergic reactions. Methods We prospectively selected 150 patients with CRS treated in Baoshan District Dacheng Hospital in Shanghai and Dawn Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from May 2015 to May 2017. Clinical data and skin prick test results were collected, and the ratio of neutrophils and eosinophils in the blood, and their association with the onset of CRS, were analyzed. Results The pathological diagnosis showed that 45 cases were neutrophilic and 105 cases were eosinophilic. The percentage of eosinophilic granulocytes in the blood of patients with infiltrating eosinophils was significantly higher than that in the blood of patients with infiltrating neutrophils(P < 0.05). There were no significant differences in the distribution of CRS without nasal polyps, CRS with nasal polyps, and immunopathological features between the two groups of infiltrated patients(P>0.05). Conclusion The degree of infiltration of neutrophils and eosinophils in the pathological tissues of CRS patients was related to the ratio of eosinophils in the blood, and the degree of infiltration of local eosinophils and peripheral blood eosinophils appeared to be consistent.

Key words: Neutrophils, Nasal polyps, Eosinophils, Rhinosinusitis, chronic

中图分类号:

R765.4

张劼,龚齐. 不同分型慢性鼻-鼻窦炎患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 54-57.

ZHANG Jie, GONG Qi. Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 54-57.

参考文献

[1] 伦杰, 张亚楠. 慢性鼻-鼻窦炎伴鼻息肉复发的相关影响因素分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(3):80-83. LUN Jie, ZHANG Yanan. Analysis on the factors related to the recurrence of chronic rhinosinusitis with nasal polyps[J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(3):80-83.
[2] Berlo DV, Vankelecom IFJ, Bruggen BVD. Parameters determining transport mechanisms through unfilled and silicalite filled PDMS-based membranes and dense PI membranes in solvent resistant nanofiltration: Comparison with pervaporation[J]. J Membrane Sci, 2011, 374(1):138-149.
[3] 王成硕, 娄鸿飞, 孟一帆, 等. 组织嗜酸粒细胞增多对慢性鼻-鼻窦炎伴鼻息肉复发的预测价值研究[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(4):268-272. WANG Chengshuo, LOU Hongfei, MENG Yifan, et al. Predictive significance of tissue eosinophilia for nasal polyp recurrence[J]. Chin J Otorhinolaryngol Head Neck Surg, 2016, 51(4):268-272.
[4] 朱丽, 马芙蓉, 王丽,等. 变应性鼻炎标准化变应原皮肤点刺试验[J]. 中国耳鼻咽喉头颈外科, 2007, 14(1):14-16. ZHU Li, MA Furong, WANG Li, et al. Analysis of skin prick test with standardized antigens in patients with allergic rhinitis[J]. Otorhinolaryngol Head Neck Surg, 2007, 14(1):14-16.
[5] 王彤, 周兵, 张盛忠,等. 慢性鼻-鼻窦炎CT筛窦分型组织病理学与预后相关性[J]. 中华耳鼻咽喉头颈外科杂志, 2008, 43(11):809-813. WANG Tong, ZHOU Bing, ZHANG Shengrong, et al. Histolopathologic features of CT scan typing of chronic rhinosinusitis and relation with prognosis[J]. J Otorhinolaryngol Head Neck Surg, 2008, 43(11):809-813.
[6] Ho J, Bailey M, Zaunders J, et al. Group 2 innate lymphoid cells(ILC2s)are increased in chronic rhinosinusitis with nasal polyps or eosinophilia[J]. Clin Exp Allergy J Br Society Allergy Clin Immunol, 2015, 45(2):394-396.
[7] 白银, 奥彦云, 徐丛,等. 慢性鼻-鼻窦炎临床表型及炎性特征的初步分析[J]. 临床耳鼻咽喉头颈外科杂志, 2017,5(2):107-110. BAI Yin, AO Yanyun, XU Chong, et al. Chronic rhinosinusitis CT ethmoid sinus histopathology and prognosis[J]. J Clin Otorhinolaryngol Head Neck Surg, 2017, 5(2):107-110.
[8] Shin HW, Kim DK, Park MH, et al. IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis[J]. J Allergy Clinical Immunol,2015, 135(6):1476-1480.
[9] 邹华, 刘翔, 田鹏, 等. 不同类型鼻息肉患者外周血Th17细胞含量的变化及意义[J]. 中国耳鼻咽喉头颈外科, 2016, 23(4):230-234. ZOU Hua, LIU Xiang, TIAN Peng, et al. Change of peripheral blood Th17 cells and its signiifcance in patients with different kinds of chronic rhinosinusitis with nasal polyps[J]. Chin Arch Otolaryngol Head Neck Surg, 2016, 23(4):230-234.
[10] Boita M, Garzaro M, Raimondo L, et al. Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression[J]. Innate Immunty, 2015, 21(2):167-172.
[11] Rugin A, Rusu T, Ioniuc I. Allergic comorbidities in bronchial asthmain children[J]. Rev Med Chir Soc Med Nat Iasi, 2010, 114(3):633-635.
[12] Rix I, Håkansson K, Larsen CG, et al. Management of chronic rhinosinusitis with nasal polyps and coexisting asthma: A systematic review[J]. Am J Rhinol Allergy, 2015, 29(3):193-195.
[13] 方利洲, 张剑青. 痰嗜酸性粒细胞检测与AECOPD全身激素使用关系[J]. 基因组学与应用生物学, 2016, 35(7):1623-1628.
[14] 梁联哨,邓静敏, 邹小英, 等.中性粒细胞性慢性持续期哮喘患者治疗前后外周血和诱导痰中嗜酸性粒细胞阳离子蛋白水平及其临床意义[J]. 广西医学, 2016, 38(3):324-327. LIANG Lianshao, DENG Jingmin, ZOU Xiaoying, et al. Peripheral blood and induced sputum levels of eosinophil cationic protein in patients with chronic persistent neutrophilic asthma before and after treatment and its clinical significance[J]. Guangxi Med J, 2016, 38(3):324-327.
[15] Yacoub MR, Trimarchi M, Cremona G, et al. Are atopy and eosinophilic bronchial inflammation associated with relapsing forms of chronic rhinosinusitis with nasal polyps[J]. Clin Mol Allergy, 2015, 13(1):23-26.

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