山东大学耳鼻喉眼学报 ›› 2019, Vol. 33 ›› Issue (4): 155-161.doi: 10.6040/j.issn.1673-3770.0.2018.561
闫志刚,张慧慧,于丹,刘岩,文连姬,王迪
YAN Zhigang, ZHANG Huihui, YU Dan, LIU Yan, WEN Lianji, WANG Di
摘要: 阻塞性睡眠呼吸暂停综合征(OSAS)是一种发病率较高的睡眠及呼吸障碍性疾病,可对全身多系统及器官产生损害。近年研究发现,OSAS可导致认知功能障碍,但其具体发病机制尚不明确,可能与慢性间歇低氧、睡眠结构紊乱等有关。认知功能障碍对OSAS患者的生活及工作产生了诸多不利影响。对OSAS伴发的认知功能障碍进行早期诊断及治疗对认知功能障碍的改善具有积极意义。
中图分类号:
[1] | 王红梅, 李连贺. 神经心理量表联合事件相关电位对中、重度阻塞性睡眠呼吸暂停低通气综合征患者轻度认知功能障碍的评价[J]. 山东大学耳鼻喉眼学报,2018, 32(2): 56-61. doi:10.6040/j.issn.1673-3770.0.2017.427. WANG Hongmei, LI Lianhe. The evaluation on mild cognitive impairment in patients with moderate-severe obstructive sleep apnea and hypopnea syndrome using neuropsychological scales and event related potential[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(2): 56-61. doi:10.6040/j.issn.1673-3770.0.2017.427. |
[2] | Bucks RS, Olaithe M, Rosenzweig I, et al. Reviewing the relationship between OSA and cognition: Where do we go from here?[J]. Respirology, 2017, 22(7): 1253-1261. doi:10.1111/resp.13140. |
[3] | D'Rozario AL, Cross NE, Vakulin A, et al. Quantitative electroencephalogram measures in adult obstructive sleep apnea-potential biomarkers of neurobehavioural functioning[J]. Sleep Medicine Reviews, 2017, 36: 29-42. doi:10.1016/j.smrv.2016.10.003. |
[4] | Zhou L, Chen P, Peng YT, et al. Role of oxidative stress in the neurocognitive dysfunction of obstructive sleep apnea syndrome[J]. Oxidative Medicine and Cellular Longevity, 2016, 2016: 1-15. doi:10.1155/2016/9626831. |
[5] | Polsek D, Gildeh N, Cash D, et al. Obstructive sleep apnoea and Alzheimer's disease: in search of shared pathomechanisms[J]. Neuroscience & Biobehavioral Reviews, 2018, 86: 142-149. doi:10.1016/j.neubiorev.2017.12.004. |
[6] | 吴宏赟, 齐向华. 功能磁共振在睡眠障碍中的应用进展[J]. 中国医药导报, 2014, 11(6): 159-161,166. WU Hongyun, QI Xianghua. Research application of functional magnetic resonance image in the sleep disorders[J]. China Medical Herald, 2014, 11(6): 159-161,166. |
[7] | Van Eldik LJ, Wainwright MS. The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain. Restor Neurol Neurosci, 2003, 21(3-4): 97-108. |
[8] | Wang WH, He GP, Xiao XP, et al. Relationship between brain-derived neurotrophic factor and cognitive function of obstructive sleep apnea/hypopnea syndrome patients[J]. Asian Pacific Journal of Tropical Medicine, 2012, 5(11): 906-910. doi:10.1016/s1995-7645(12)60169-2. |
[9] | Nasreddine ZS, Phillips NA, Bédirian V,et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment[J]. Am Geriatr Soc,2005,53(4):695-699. doi:10.1111/j.1532-5415.2005.53221.x. |
[10] | O'Driscoll C, Shaikh M. Cross-cultural applicability of the montreal cognitive assessment(MoCA): a systematic review[J]. JAD, 2017, 58(3): 789-801. doi:10.3233/jad-161042. |
[11] | Yang LX, Tang X, Zhou N, et al. Application and reliability verification of Beijing-based cognitive assessment scale of montreal in cognitive function of adult OSAHS[J]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2018, 32(1): 58-64. |
[12] | Popovic IM, Lovrencic-Huzjan A, Simundic AM, et al. Cognitive performance in asymptomatic patients with advanced carotid disease[J]. Cognitive And Behavioral Neurology, 2011, 24(3): 145-151. doi:10.1097/wnn.0b013e3182313020. |
[13] | 穆新暖, 王滨, 王晓芝, 等. 呼吸睡眠暂停低通气患者脑功能的功能性MRI诊断[J]. 放射学实践, 2017, 32(1): 16-20. doi:10.13609/j.cnki.1000-0313.2017.01.004. MU Xinnuan, WANG Bin, WANG Xiaozhi, et al. Functional magnetic resonance imaging in obstructive sleep apnea hypopnea syndrome patients before and after continuous positive airway pressure treatment[J]. Radiologic Practice, 2017, 32(1): 16-20. doi:10.13609/j.cnki.1000-0313.2017.01.004. |
[14] | Pereira AC, Mao XL, Jiang CS, et al. Dorsolateral prefrontal cortex GABA deficit in older adults with sleep-disordered breathing[J]. Proc Natl Acad Sci USA, 2017, 114(38): 10250-10255. doi:10.1073/pnas.1700177114. |
[15] | Tummala S, Palomares J, Kang DW, et al. Global and regional brain non-gaussian diffusion changes in newly diagnosed patients with obstructive sleep apnea[J]. Sleep, 2016, 39(1): 51-57. doi:10.5665/sleep.5316. |
[16] | Inoue Y, Nanba K, Kojima K, et al. P300 abnormalities in patients with severe sleep apnea syndrome[J]. Psychiatry and Clinical Neurosciences, 2001, 55(3): 247-248. doi:10.1046/j.1440-1819.2001.00844.x. |
[17] | Puskás S, Kozák N, Sulina D, et al. Quantitative EEG in obstructive sleep apnea syndrome: a review of the literature[J]. Reviews in the Neurosciences, 2017, 28(3): 265-270. doi:10.1515/revneuro-2016-0064. |
[18] | Puche JE,Mu(~overn)oz U, García-Magari(~overn)o M,et al. Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy[J]. Biofactors,2016,42(1):60-79.doi:10.1002/biof.1255. |
[19] | Izumi S, Ribeiro-Filho FF, Carneiro G, et al. IGF-1 levels are inversely associated with metabolic syndrome in obstructive sleep apnea[J]. JCSM, 2016, 12(4): 487-493. doi:10.5664/jcsm.5672. |
[20] | Mysliwiec V, Gill J, Matsangas P, et al. IGF-1: a potential biomarker for efficacy of sleep improvement with automatic airway pressure therapy for obstructive sleep apnea[J]. Sleep Breath, 2015, 19(4): 1221-1228. doi:10.1007/s11325-015-1142-x. |
[21] | Kanbay A, Demir NC, Tutar N, et al. The effect of CPAP therapy on insulin-like growth factor and cognitive functions in obstructive sleep apnea patients[J]. The Clinical Respiratory Journal, 2017, 11(4): 506-513. doi:10.1111/crj.12365. |
[22] | Hoyos CM, Killick R, Keenan DM, et al. Continuous positive airway pressure increases pulsatile growth hormone secretion and circulating insulin-like growth factor-1 in a time-dependent manner in men with obstructive sleep apnea: a randomized sham-controlled study[J]. Sleep, 2014, 37(4): 733-741. doi:10.5665/sleep.3580. |
[23] | 李洁,冯明亮.阻塞性睡眠呼吸暂停低通气综合征患者血清S-100β、神经元特异性烯醇化酶水平变化及其与认知功能的相关性[J].实用心脑血管肺病杂志, 2017,25(4):162-164. doi:10.3969/j.issn.1008-5971.2017.04.047. LI Jie,FENG Mingliang.Change of serum levels of S-100β and NSE in patients with obstructive sleep apnea hypopnea syndrom and the correlation with cognitive function [J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2017, 25(4):162-164.doi:10.3969/j.issn.1008-5971.2017.04.047. |
[24] | JIANG Qingsong, LIANG Ziliang, WU Minjie, et al. Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMP8 mice[J]. Chinese Medical Journal, 2011, 124(10): 1540-1544. doi:10.3760/cma.j.issn.0366-6999.2011.10.019. |
[25] | Giacobbo BL, Corrêa MS, Vedovelli K, et al. Could BDNF be involved in compensatory mechanisms to maintain cognitive performance despite acute sleep deprivation? An exploratory study[J]. International Journal of Psychophysiology, 2016, 99: 96-102. doi:10.1016/j.ijpsycho.2015.11.008. |
[26] | 梁春荣, 刘雨辉, 王叶冉, 等. 阿尔茨海默病患者外周血炎症因子水平与认知功能的相关性研究[J]. 解放军医学杂志, 2014, 39(2): 133-137. doi:10.11855/j.issn.0577-7402.2014.02.11. LIANG Chunrong, LIU Yuhui, WANG Yeran, et al. Correlation between serum inflammatory factor levels and cognitive function in patients with Alzheimer's disease[J]. Medical Journal of Chinese People's Liberation Army, 2014, 39(2): 133-137. doi:10.11855/j.issn.0577-7402.2014.02.11. |
[27] | Hansson O, Zetterberg H, Buchhave P, et al. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study[J]. The Lancet Neurology, 2006, 5(3): 228-234. doi:10.1016/s1474-4422(06)70355-6. |
[28] | 谭曦舒,李立群,胡玲玲,等.OSAHS患者HCY、SAA水平与认知功能的关系研究[J].中国现代医学杂志,2017,27(1): 82-85. doi:10.3969/j.issn.1005-8982.2017.01.016. TAN Xishu, LI Liqun,HU Lingling,et al. Correlations of serum homocysteine and amyloid protein A levels with cognitive function in patients with obstructive sleep apnea hypopnea syndrome[J].China Journal of Modern Medicine, 2017, 27(1):82-85.doi:10.3969/j.issn.1005-8982.2017.01.016. |
[29] | Canessa N,Castronovo V,Cappa SF,et al.Obstructive sleep apnea: Brain structural changes and neurocognitive function before and after treatment.Am J Respir Crit Care Med, 2011, 183(10):1419-1426. doi:10.1164/rccm.201005-0693OC. |
[30] | Dalmases M, Solé-Padullés C, Torres M, et al. Effect of CPAP on cognition, brain function, and structure among elderly patients with OSA[J]. Chest, 2015, 148(5): 1214-1223. doi:10.1378/chest.15-0171. |
[31] | Engleman HM, Martin SE, Deary IJ, et al. Effect of CPAP therapy on daytime function in patients with mild sleep apnoea/hypopnoea syndrome[J]. Thorax, 1997, 52(2): 114-119. doi:10.1136/thx.52.2.114. |
[32] | Rosenzweig I, Glasser M, Crum WR, et al. Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure[J]. EBio Medicine, 2016, 7: 221-229. doi:10.1016/j.ebiom.2016.03.020. |
[33] | Jurádo-Gámez B, Guglielmi O, Gude F, et al. Effects of continuous positive airway pressure treatment on cognitive functions in patients with severe obstructive sleep apnoea[J]. Neurología(English Edition), 2016, 31(5): 311-318. doi:10.1016/j.nrleng.2015.03.008. |
[34] | Bardwell WA, Ancoli-Israel S, Berry CC, et al. Neuropsychological effects of one-week continuous positive airway pressure treatment in patients with obstructive sleep apnea: a placebo-controlled study[J]. Psychosomatic Medicine, 2001, 63(4): 579-584. doi:10.1097/00006842-200107000-00010. |
[35] | Mulgrew AT, Lawati NA, Ayas NT, et al. Residual sleep apnea on polysomnography after 3 months of CPAP therapy: clinical implications, predictors and patterns[J]. Sleep Medicine, 2010, 11(2): 119-125. doi:10.1016/j.sleep.2009.05.017. |
[36] | Karimi M, Hedner J, Lombardi C, et al. Driving habits and risk factors for traffic accidents among sleep apnea patients-a European multi-centre cohort study[J]. J Sleep Res, 2014, 23(6): 689-699. doi:10.1111/jsr.12171. |
[37] | Avellar ABCC, Carvalho LBC, Prado GF, et al. Pharmacotherapy for residual excessive sleepiness and cognition in CPAP-treated patients with obstructive sleep apnea syndrome: a systematic review and meta-analysis[J]. Sleep Medicine Reviews, 2016, 30: 97-107. doi:10.1016/j.smrv.2015.10.005. |
[38] | 张盼盼, 汪彦辉, 韩晓庆, 等. 丁苯酞对老年OSAHS患者氧化应激及认知功能的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2018, 32(18): 1422-1425. doi:10.13201/j.issn.1001-1781.2018.18.014. ZHANG Panpan, WANG Yanhui, HAN Xiaoqing, et al. Effect of butylphthalide on oxidative stress and cognitive function in old obstructive sleep apnea hypopnea syndrome patients[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2018, 32(18): 1422-1425. doi:10.13201/j.issn.1001-1781.2018.18.014. |
[39] | Lal C, Siddiqi N, Kumbhare S, et al. Impact of medications on cognitive function in obstructive sleep apnea syndrome[J]. Sleep Breath, 2015, 19(3): 939-945. doi:10.1007/s11325-014-1105-7. |
[40] | Voss MW, Vivar C, Kramer AF, et al. Bridging animal and human models of exercise-induced brain plasticity[J]. Trends in Cognitive Sciences, 2013, 17(10): 525-544. doi:10.1016/j.tics.2013.08.001. |
[1] | 刘鸣. 早期声门癌的内镜治疗[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 6-9. |
[2] | 崔晓波. 诱导化疗在局部晚期下咽癌治疗中的意义[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 10-17. |
[3] | 申宇鹏,宋琦,李晓明. 喉癌前病变的病因、分子机制和处理策略[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 25-30. |
[4] | 钟晓声,杨海弟,郑亿庆. 突发性聋伴耳鸣的治疗与转归[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 43-46. |
[5] | 张贵阳,黄河,冼志,张汉文,谢桂彩. 粉尘螨滴剂舌下含服免疫治疗对不同年龄段变应性鼻炎患者的临床效果评估[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 60-65. |
[6] | 罗通勇,杨华清,岳胜清,贾全凡,袁龙. 帕尼单抗和紫杉醇一线治疗复发或转移性头颈肿瘤Ⅱ期患者效果观察[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 71-75. |
[7] | 宋凡,黄炜峻,许华俊,关建,易红良. 阻塞性睡眠呼吸暂停综合征患者颈动脉弹性与氧化应激反应的关系[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 99-104. |
[8] | 季迪,陈祥,余林. 软腭平面手术联合舌骨悬吊术治疗阻塞性睡眠呼吸暂停综合征效果的Meta分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 124-130. |
[9] | 刘燕,魏萍,寇巍,胡思洁,武小芳,刘萌雅,陈成,姚红兵. 儿童腺样体肥大与耳鼻咽喉科常见疾病关系的研究进展[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 149-154. |
[10] | 赵青,周涵,殷敏,冯剑,张佳程,刘雅琴,沈宇杰,林子萍,董伟达. 鼻咽纤维血管瘤术前超选择性血管栓塞的应用价值[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 100-105. |
[11] | 郎永耀,杨云,刘晴,徐林弟,林子萍. 咽喉反流性疾病的影响因素及治疗效果分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 119-123. |
[12] | 冯剑,周涵,董伟达. 喉癌内镜诊断技术研究进展[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 129-133. |
[13] | 殷敏,程雷. 鼾症命名之我见[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 19-22. |
[14] | 李晓璐. 前庭性偏头痛与几种常见周围性眩晕的鉴别诊断[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 23-26. |
[15] | 王登元,陈智斌,王杪琳. 伴发梅尼埃病的良性阵发性位置性眩晕的临床特点[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 61-65. |
|