山东大学耳鼻喉眼学报 ›› 2019, Vol. 33 ›› Issue (5): 153-157.doi: 10.6040/j.issn.1673-3770.0.2018.314

• 综述 • 上一篇    

角膜胶原交联术治疗感染性角膜疾病研究进展

高芯1,综述1,2,王旭2(),审校1,2   

  1. 1. 济南大学 山东省医学科学院医学与生命科学学院，山东 济南 250200
    2. 济南市第二人民医院眼表疾病科，山东 济南 250000
  • 收稿日期:2018-07-03 修回日期:2019-08-15 出版日期:2019-09-20 发布日期:2019-10-15
  • 通讯作者: 王旭 E-mail:wangxuzou@126.com

A review of corneal collagen cross-linking for the treatment of infectious corneal disease

Xin GAO1,Xu WANG1,2   

  1. 1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, Shandong，China
    2. Ocular Surface Department，Jinan Second People′s Hospital，Jinan 250000, Shandong，China
  • Received:2018-07-03 Revised:2019-08-15 Online:2019-09-20 Published:2019-10-15

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摘要：

角膜胶原交联术（CXL）利用紫外光A和感光剂核黄素，介导角膜基质内胶原纤维相互交联,提高角膜机械硬度和角膜基质的生物力学稳定性，从而阻止圆锥角膜等扩张性疾病的进展。近年来，经过临床研究发现，CXL对感染性角膜疾病的治疗也能取得良好的治疗效果，因此CXL成为了一种安全、有效的治疗感染性角膜疾病的新方法。综述该技术在治疗感染性角膜疾病方面的研究进展，回顾分析了该技术的基本原理，治疗感染性角膜疾病的作用机制、适应证、禁忌证、治疗技术的研究。

关键词: 角膜胶原交联术, 感染性角膜疾病, 适应证, 禁忌证

Abstract:

Corneal collagen crosslinking (CXL) using ultraviolet light (UVA)-riboflavin photochemistry increases corneal rigidity and improves biomechanical stability of the stroma, thereby limiting the progression of corneal expansion. In recent years, CXL has also been used as a safe and effective treatment for infectious corneal diseases. In this paper, we review the basic principles, indications, and contraindication of CXL for the treatment of infectious corneal disease.

Key words: Corneal collagen cross linking, Infectious corneal disease, Indications, Contraindication

中图分类号: 

  • R772.2
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