自噬及其在青光眼中的研究进展

doi:10.6040/j.issn.1673-3770.0.2018.606

摘要/Abstract

摘要：

自噬是细胞通过降解更新细胞内异常的蛋白质、糖原、受损细胞器等累积物，并释放出对细胞有利的小分子物质进行二次利用，以维持细胞内稳态的一种细胞代谢过程。自噬调控异常与人体多种疾病相关，包括肿瘤、免疫性疾病、神经退行性疾病等。近年来发现，自噬参与青光眼疾病的生理病理过程，在其促进神经节细胞的生存和死亡方面仍存在一定的争议。故深入研究自噬的发生及机制，对全面了解自噬对青光眼疾病发生发展有着重要意义。

关键词: 自噬, 神经退行性疾病, 青光眼

Abstract:

Autophagy is a cellular metabolic process in which cells degrade and renew abnormal proteins, glycogen, damaged organelles, and other accumulations and release small molecules favorable for secondary utilization by cells to maintain intracellular homeostasis. It is a unique life phenomenon in eukaryotic cells and plays an important role in cell growth, development, and aging. Activation of abnormal autophagy is associated with various diseases, including tumor, immune disorders, and neurodegenerative diseases, in the human body. In recent years, it has been found that autophagy is involved in the physiological and pathological process of glaucoma; however, whether autophagy promotes the survival or death of retinal ganglion cells remains controversial. Therefore, an in-depth study on the occurrence and mechanism of autophagy is of great significance for a comprehensive understanding of the role of autophagy in the pathogenesis of glaucoma.

Key words: Autophagy, Neurodegenerative diseases, Glaucoma

中图分类号:

R774

刘瑞宝,赵颖,郭明璐,段钰,吴艳霞,路雪婧. 自噬及其在青光眼中的研究进展[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 158-161.

Ruibao LIU,Ying ZHAO,Minglu GUO,Yu DUAN,Yanxia WU,Xuejing LU. Autophagy and its research progress in glaucoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 158-161.

参考文献 31

1	方灏, 吴昌静, 李斯慧, 等 . 自噬与视网膜疾病[J]. 解剖科学进展, 2016, 22(4): 429-431. doi:10.16695/j.cnki. 1006-2947.2016.04.020 . doi: 10.16695/j.cnki.1006-2947.2016.04.020
	FANG Hao , WU Changjing , LI Sihui , et al . Autophagy and retinal diseases[J]. Progress of Anatomical Sciences, 2016, 22(4): 429-431. doi:10.16695/j.cnki.1006-2947.2016.04.020 . doi: 10.16695/j.cnki.1006-2947.2016.04.020
2	Zhang HB , Sun NX , Liang HC ，et al . 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model[J]. Jpn J Ophthalmol，2012，56(4):407-415. doi: 10.1007/s10384-012-0136-5 . doi: 10.1007/s10384-012-0136-5
3	Olzscha H , Schermann SM , Woerner AC , et al . Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions[J]. Cell, 2011, 144(1): 67-78. doi:10.1016/j.cell.2010.11.050 . doi: 10.1016/j.cell.2010.11.050
4	Murrow L , Debnath J . Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease[J]. Annu Rev Pathol, 2013, 8: 105-137. doi:10.1146/annurev-pathol-020712-163918 . doi: 10.1146/annurev-pathol-020712-163918
5	Feng YC , He D , Yao ZY , et al . The machinery of macroautophagy[J]. Cell Res, 2014, 24(1): 24-41. doi:10.1038/cr.2013.168 . doi: 10.1038/cr.2013.168
6	Yu L , Chen Y , Tooze SA . Autophagy pathway: Cellular and molecular mechanisms[J]. Autophagy, 2018, 14(2): 207-215. doi:10.1080/15548627.2017.1378838 . doi: 10.1080/15548627.2017.1378838
7	Stolz A , Ernst A , Dikic I . Cargo recognition and trafficking in selective autophagy[J]. Nat Cell Biol, 2014, 16(6): 495-501. doi:10.1038/ncb2979 . doi: 10.1038/ncb2979
8	冯会超 . 细胞自噬与神经退行性疾病机制的研究进展[J]. 临床与病理杂志, 2018, 38(3): 659-663. doi:10.3978/j.issn.2095-6959.2018.03.033 . doi: 10.3978/j.issn.2095-6959.2018.03.033
	FENG Huichao . Advances in mechanisms of autophagy and neurodegenerative diseases[J]. International Journal of Pathology and Clinical Medicine, 2018, 38(3): 659-663. doi:10.3978/j.issn.2095-6959.2018.03.033 . doi: 10.3978/j.issn.2095-6959.2018.03.033
9	Randhawa R , Sehgal M , Singh TR , et al . Unc-51 like kinase 1 (ULK₁) in silico analysis for biomarker identification: a vital component of autophagy[J].Gene,2015, 562(1): 40-49. doi:10.1016/j.gene.2015.02.056 . doi: 10.1016/j.gene.2015.02.056
10	Wang Y , Xu K , Zhang HB , et al . Retinal ganglion cell death is triggered by paraptosis via reactive oxygen species production: a brief literature review presenting a novel hypothesis in glaucoma pathology[J]. Mol Med Rep, 2014, 10(3): 1179-1183. doi:10.3892/mmr. 2014. 2346 . doi: 10.3892/mmr. 2014. 2346
11	Weinreb RN , Aung T , Medeiros FA . The pathophysiology and treatment of glaucoma: a review[J]. JAMA, 2014, 311(18): 1901-1911. doi:10.1001/jama. 2014. 3192 . doi: 10.1001/jama. 2014. 3192
12	Cho KJ , Kim JH , Park HY , et al . Glial cell response and iNOS expression in the optic nerve head and retina of the rat following acute high IOP ischemia-reperfusion[J]. Brain Res, 2011, 1403: 67-77. doi:10.1016/j.brainres. 2011.06.005 . doi: 10.1016/j.brainres. 2011.06.005
13	Li R , Jin YP , Li Q , et al . MiR-93-5p targeting PTEN regulates the NMDA-induced autophagy of retinal ganglion cells via AKT/mTOR pathway in glaucoma[J]. Biomed Pharmacother, 2018, 100: 1-7. doi:10.1016/j.biopha.2018.01.044 . doi: 10.1016/j.biopha.2018.01.044
14	Park HY , Kim JH , Park CK . Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model[J]. Cell Death Dis, 2012, 3: e290. doi:10.1038/cddis.2012.26 . doi: 10.1038/cddis.2012.26
15	Wang Y , Huang CQ , Zhang HB , et al . Autophagy in glaucoma: Crosstalk with apoptosis and its implications[J]. Brain Research Bulletin, 2015, 117: 1-9. doi:10.1016/j.brainresbull.2015.06.001 . doi: 10.1016/j.brainresbull.2015.06.001
16	Deng SF , Wang M , Yan ZC , et al . Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model[J]. PLoS One, 2013, 8(10): e77100. doi:10.1371/journal.pone.0077100 . doi: 10.1371/journal.pone.0077100
17	Piras A , Gianetto D , Conte D , et al . Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure[J]. PLoS One, 2011, 6(7): e22514. doi:10.1371/journal.pone.0022514 . doi: 10.1371/journal.pone.0022514
18	Hirt J , Porter K , Dixon A , et al . Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model[J]. Cell Death Discov, 2018, 4: 14. doi:10.1038/s41420-018-0077-y . doi: 10.1038/s41420-018-0077-y
19	Stamer WD , Acott TS . Current understanding of conventional outflow dysfunction in glaucoma[J]. Curr Opin Ophthalmol, 2012, 23(2): 135-143. doi:10.1097/ICU.0b013e32834ff23e . doi: 10.1097/ICU.0b013e32834ff23e
20	Porter K , Nallathambi J , Lin YZ , et al . Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis[J]. Autophagy, 2013, 9(4): 581-594. doi:10.4161/auto.23568 . doi: 10.4161/auto.23568
21	Porter K , Hirt J , Stamer WD , et al . Autophagic dysregulation in glaucomatous trabecular meshwork cells[J]. Biochim Biophys Acta, 2015, 1852(3): 379-385. doi:10.1016/j.bbadis.2014.11.021 . doi: 10.1016/j.bbadis.2014.11.021
22	Stothert AR , Fontaine SN , Sabbagh JJ , et al . Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma[J]. Exp Eye Res, 2016, 144: 38-45. doi:10.1016/j.exer.2015.08.017 . doi: 10.1016/j.exer.2015.08.017
23	Kunchithapautham K , Rohrer B . Autophagy is one of the multiple mechanisms active in photoreceptor degeneration[J]. Autophagy, 2007, 3(1): 65-66. doi:10.4161/auto.3431 . doi: 10.4161/auto.3431
24	Park HL , Kim JH , Park CK . Different contributions of autophagy to retinal ganglion cell death in the diabetic and glaucomatous retinas[J]. Sci Rep, 2018, 8(1): 13321. doi:10.1038/s41598-018-30165-7 . doi: 10.1038/s41598-018-30165-7
25	Kaarniranta K , Kauppinen A , Blasiak J , et al . Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration[J]. Future Med Chem, 2012, 4(17): 2153-2161. doi:10.4155/fmc. 12. 169 . doi: 10.4155/fmc. 12. 169
26	Rodríguez-Muela N , Germain F , Mariño G , et al . Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice[J]. Cell Death Differ, 2012, 19(1): 162-169. doi:10.1038/cdd.2011.88 . doi: 10.1038/cdd.2011.88
27	Su WR , Li ZH , Jia Y , et al . Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model[J]. PLoS One, 2014, 9(6): e99719. doi:10.1371/journal.pone.0099719 . doi: 10.1371/journal.pone.0099719
28	Fingert JH , Robin AL , Stone JL , et al . Copy number variations on chromosome 12q14 in patients with normal tension glaucoma[J]. Hum Mol Genet, 2011, 20(12): 2482-2494. doi:10.1093/hmg/ddr123 . doi: 10.1093/hmg/ddr123
29	Fingert JH . Primary open-angle glaucoma genes[J]. Eye (Lond), 2011, 25(5): 587-595. doi:10.1038/eye. 2011.97 . doi: 10.1038/eye. 2011.97
30	Alward WL , Fingert JH , Coote MA, et al . Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC₁A)[J]. N Engl J Med, 1998, 338(15): 1022-1027. doi:10.1056/NEJM-199804093381503 . doi: 10.1056/NEJM-199804093381503
31	Tucker BA, Solivan-Timpe F , Roos BR , et al . Duplication of TBK₁ stimulates autophagy in iPSC-derived retinal cells from a patient with normal tension glaucoma[J]. J Stem Cell Res Ther, 2014, 3(5): 161. doi:10.4172/2157-7633.1000161 . doi: 10.4172/2157-7633.1000161

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