IL-36在慢性鼻-鼻窦炎伴鼻息肉中的研究进展

doi:10.6040/j.issn.1673-3770.0.2020.146

摘要/Abstract

摘要： 白介素-36(IL-36)是IL-1超家族成员(IL-1F)之一,在上皮细胞和特异性免疫细胞中具有生物活性,主要功能包括促进细胞的活化、分泌细胞因子和趋化因子、招募和激活不同的免疫细胞等。近年有学者研究发现,IL-36家族在慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)发病中具有一定的作用。就IL-36的生物学特征及其在慢性鼻-鼻窦炎伴鼻息肉中促进炎症反应、组织重塑、破坏上皮屏障等方面的研究进展进行综述。

关键词: IL-36, CRSwNP, 免疫应答, 组织重塑, 上皮屏障

Abstract: Interleukin-36(IL-36), a member of the IL-1 superfamily(IL-1F), is biologically active in epithelial cells and in specific immune cells. Its main functions include promoting cell activation, secreting cytokines and chemokines, and recruiting and activating different immune cells. Recent studies have found that the IL-36 family has a role in the pathogenesis of chronic rhinosinusitis with nasal polyps(CRSwNP). This article reviews the research progress and biological characteristics of IL-36 in promoting the inflammatory response, tissue remodeling, and disrupting the epithelial barrier in chronic rhinosinusitis with nasal polyps.

Key words: IL-36, CRSwNP, Immune response, Tissue Inhibitor of Metalloproteinases, Epithelial barrier

中图分类号:

765.4

慕婷婷,杨玉娟,张宇,宋西成. IL-36在慢性鼻-鼻窦炎伴鼻息肉中的研究进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(1): 114-118.

MU Tingting, YANG Yujuan. Research progress of IL-36 in chronic rhinosinusitis with nasal polyps[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 114-118.

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