芳香烃受体抑制变应性鼻炎Th17免疫应答的研究进展

doi:10.6040/j.issn.1673-3770.0.2020.037

摘要/Abstract

摘要： 变应性鼻炎是指特应性个体暴露于变应原后由IgE介导的鼻变应性疾病。在探讨其发病机制时,仅单纯研究Th1/Th2细胞模式已不适用,而Th1/Th2及Thl7/Treg细胞模式近来受到广泛关注。芳香烃受体(AhR)属于螺旋-环-螺旋蛋白家族的成员,其在激活后能够通过调控树突状细胞和T淋巴细胞的分化进而发挥强大的免疫调节能力,这种潜能可以在某些自身免疫和过敏性疾病中发挥保护作用。综述AhR激活与AR患者Th17免疫应答相关性的研究,为AR的进一步诊断和治疗提供新的线索。

关键词: 变应性鼻炎, Th17, Treg, 芳香烃受体

Abstract: Allergic rhinitis(AR)is an immunoglobulin E(IgE)-mediated inflammatory response on the nasal mucous membranes that usually ensues contact with allergens. Studies on a Th1/Th2 cell model alone are not sufficient for discussing the pathogenesis of AR; hence, the Th1/Th2; Thl7/Treg cell model has recently been a topic of concern. The aryl hydrocarbon receptor(AhR)is a member of the basic helix-loop-helix/PER-ARNT-SIM family, which is activated by its ligand and expresses strong immunomodulation potential by regulating the differentiation of T lymphocytes and dendritic cells. This effect may play a protective role in autoimmune and allergic diseases. This report summarizes our study on the correlation between AhR activation and Th17 immune responses in AR patients, and provides new insights for further diagnosis and treatment of AR.

Key words: Allergic rhinitis, Th17, Treg, Aryl hydrocarbon receptor

中图分类号:

R765.21

杨艳艳,杨玉娟,宋西成. 芳香烃受体抑制变应性鼻炎Th17免疫应答的研究进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(1): 109-113.

YANG Yanyan, YANG Yujuan,SONG Xicheng. Progress in aryl hydrocarbon receptor-induced inhibition of Th17 immune response in allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 109-113.

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