内分泌激素与嗓音

doi:10.6040/j.issn.1673-3770.1.2020.117

摘要/Abstract

摘要： 内分泌系统与嗓音之间关系密切,激素水平波动会对发声系统的形态、结构产生影响,进而导致嗓音变化。喉部含大量的性激素和甲状腺激素受体,故性激素和甲状腺激素是导致嗓音障碍最重要的两种激素。性激素在人一生的不同阶段存在动态变化,会导致嗓音的改变,青春期和老年期变化最明显。嗓音训练治疗男声女调效果显著,极少需要手术。激素相关性药物对嗓音的影响显著,甚至不可逆,使用相关药物时需慎重。甲状腺激素降低引起的喉黏膜及声带水肿,极易被误诊为任克氏水肿,需注意鉴别诊断。耳鼻喉科医生应加深对嗓音障碍背后内分泌问题的认识,以做到更加清晰地识别。

关键词: 内分泌, 激素, 嗓音障碍, 男声女调, 声带水肿

Abstract: There is a close relationship between the endocrine system and the voice, and fluctuations in hormone levels have an impact on the shape and structure of the human vocal system, which in turn leads to voice changes. The larynx contains a large number of receptors for sex hormones and thyroid hormones, so sex hormones and thyroid hormones are the two most important hormones that cause voice disorders. Sex hormones have dynamic changes at different stages of human life, which can cause voice changes, which are most obvious in adolescence and old age. Mutational falsetto, also known as puberphonia, is very sensitive to voice training therapy, so it is necessary to be cautious when choosing surgical treatment. Furthermore, the hormone-related drugs has a significant and even irreversible impact on the voice, so caution should be used when using them. In addition, laryngeal mucosa and vocal cord edema caused by hypothyroidism can easily be misdiagnosed as Reinke's edema, which requires attention to distinguish. Finally, otolaryngologists should deepen their understanding of the endocrine problems behind voice disorders in order to more clearly identify the primary disease.

Key words: Endocrine, Hormones, Dysphonia, Mutational falsetto, Vocal cord edema

中图分类号:

R767.92

庄佩耘,刘昀逸. 内分泌激素与嗓音[J]. 山东大学耳鼻喉眼学报, 2021, 35(3): 5-9.

ZHUANG Peiyun, LIU Yunyi. Hormones and voice[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 5-9.

参考文献

[1] Abdul-Latif H, Robert TS, Mary JH. Laryngeal Manifestations of Systemic Diseases, Laryngeal Manifestasions of Endocrine Disorders[M]. United States of America:Plural Publishing, 2019.
[2] Kim JM, Shin SC, Park GC, et al. Effect of sex hormones on extracellular matrix of Lamina propria in rat vocal fold[J]. Laryngoscope, 2020, 130(3): 732-740. doi:10.1002/lary.28086.
[3] Kirgezen T, Sunter AV, Yigit O, et al. Sex hormone receptor expression in the human vocal fold subunits[J]. J Voice, 2017, 31(4): 476-482. doi:10.1016/j.jvoice.2016.11.005.
[4] Roy N, Peterson EA, Pierce JL, et al. Manual laryngeal reposturing as a primary approach for mutational falsetto[J]. Laryngoscope, 2017, 127(3): 645-650. doi:10.1002/lary.26053.
[5] Denizoglu II, Sahin M, Bayrak S, et al. Efficacy of doctorvox voice therapy technique for mutational falsetto[J]. J Voice, 2019, 33(6): 950.e1-950950.e8. doi:10.1016/j.jvoice.2018.05.012.
[6] Bruzzi C, Salsi D, Minghetti D, et al. Presbiphonya[J]. Acta Biomed, 2017,88(1): 6-10. doi: 10.23750/abm.v88i1.5266.
[7] 徐洁洁. 老年期嗓音的生理特征及保健[J]. 山东大学耳鼻喉眼学报, 2019, 33(3): 14-18. doi:10.6040/j.issn.1673-3770.1.2019.022. XU Jiejie. Physiological characteristics of voice and care of vocal health in the elderly[J]. J Otolaryngol Ophthalmol Shandong Univ, 2019, 33(3): 14-18. doi:10.6040/j.issn.1673-3770.1.2019.022.
[8] Rapoport S K, Jayme M, Nazaneen G. Voice Changes in the Elderly[J]. Otolaryngol Clin North Am, 2018, 51(4):759-768. doi: 10.1016/j.otc.2018.03.012.
[9] Shoffel-Havakuk H, Carmel-Neiderman NN, Halperin D, et al. Menstrual cycle, vocal performance, and laryngeal vascular appearance: an observational study on 17 subjects[J]. J Voice, 2018, 32(2): 226-233. doi:10.1016/j.jvoice.2017.05.001.
[10] Köyba??塂 ??塁anal S, Biçer YÖ, Kükner A, et al. Effect of pregnancy on vocal cord histology: an animal experiment[J]. Balkan Med J, 2016, 33(4): 448-452. doi:10.5152/balkanmedj.2016.15286.
[11] Akcam T, Bolu E, Merati AL, et al. Voice changes after androgen therapy for hypogonadotrophic hypogonadism[J]. Laryngoscope, 2004, 114(9): 1587-1591. doi:10.1097/00005537-200409000-00016.
[12] Hannoun A, Zreik T, Husseini ST, et al. Vocal changes in patients with polycystic ovary syndrome[J]. J Voice, 2011, 25(4): 501-504. doi:10.1016/j.jvoice.2009.12.005.
[13] Aydin K, Akbulut S, Demir MG, et al. Voice characteristics associated with polycystic ovary syndrome[J]. Laryngoscope, 2016, 126(9): 2067-2072. doi:10.1002/lary.25818.
[14] Hari Kumar KV, Garg A, Ajai Chandra NS, et al. Voice and endocrinology[J]. Indian J Endocrinol Metab, 2016, 20(5): 590-594. doi:10.4103/2230-8210.190523.
[15] Abaza MM, Levy S, Hawkshaw MJ, et al. Effects of medications on the voice[J]. Otolaryngol Clin North Am, 2007, 40(5): 1081-1090,viii. doi:10.1016/j.otc.2007.05.010.
[16] Rodney JP, Sataloff RT. The effects of hormonal contraception on the voice: history of its evolution in the literature[J]. J Voice, 2016, 30(6): 726-730. doi:10.1016/j.jvoice.2015.08.014.
[17] Amir O, Biron-Shental T, Shabtai E. Birth control pills and nonprofessional voice: acoustic analyses[J]. J Speech Lang Hear Res, 2006, 49(5): 1114-1126. doi:10.1044/1092-4388(2006/080).
[18] Kadakia S, Carlson D, Sataloff RT. The Effect of Hormones on the Voice[J]. J Singing, 2013, 69(5):571-574.
[19] Altman KW, Haines GK 3rd, Vakkalanka SK, et al. Identification of thyroid hormone receptors in the human larynx[J]. Laryngoscope, 2003, 113(11): 1931-1934. doi:10.1097/00005537-200311000-00014.
[20] Junuzovi c-Zuni c L, Ibrahimagi c A, Altumbabi c S. Voice characteristics in patients with thyroid disorders[J]. Eurasian J Med, 2019, 51(2): 101-105. doi:10.5152/eurasianjmed.2018.18331.
[21] Mohammadzadeh A, Heydari E, Azizi F. Speech impairment in primary hypothyroidism[J]. J Endocrinol Invest, 2011, 34(6): 431-433. doi:10.1007/BF03346708.
[22] 游龙贵, 张克辉, 张小安, 等. 甲状腺功能减退症致声音嘶哑误诊分析[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48(7): 596-597. doi:10.3760/cma.j.issn.1673-0860.2013.07.016.
[23] 洪剑霞,冯葆富. 内分泌障碍与发声障碍[J]. 国际耳鼻咽喉头颈外科杂志, 1978,1:8-12.

相关文章 15

[1]	许嘉, 李欣, 陈雯婧, 高娟娟, 卢星星, 伊海金. 联合应用内淋巴囊减压和局部激素治疗难治性梅尼埃病的短期与长期疗效分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 17-21.
[2]	毛泽凡陈曦,程雷. 喉神经内分泌癌的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 114-119.
[3]	王欢,胡俐,余洪猛. 慢性鼻窦炎相关嗅觉功能障碍研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 43-49.
[4]	资昊坤,肖旭平,李云秋. 口服糖皮质激素在慢性鼻窦炎伴鼻息肉围手术期的应用现状[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 98-103.
[5]	陈世琴,卫平存,胡云龙,胡金旺. 糖皮质激素三种不同鼻用法对鼻内镜术后黏膜转归的影响[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 195-201.
[6]	陈学军,高文,尹高菲,郭伟,黄俊伟,张洋. 鼻腔鼻窦神经内分泌癌8例并文献复习[J]. 山东大学耳鼻喉眼学报, 2021, 35(6): 77-82.
[7]	钟丽萍,官希龙,王晶晶,汤勇. 鼓室与全身应用激素治疗突发性耳聋的系统评价与Meta分析[J]. 山东大学耳鼻喉眼学报, 2021, 35(5): 1-10.
[8]	黄永望,傅德慧. 嗓音医学的范畴和疾病分类[J]. 山东大学耳鼻喉眼学报, 2021, 35(3): 1-4.
[9]	杨秀芬,尤冉,马秀梅,王康,王艳玲. 以医院为基础的中心性浆液性脉络膜视网膜病变流行病学调查及危险因素的研究[J]. 山东大学耳鼻喉眼学报, 2020, 34(4): 75-79.
[10]	姜洋,李莹,崔歌. 0.1%双氯芬酸钠滴眼液在SMILE术后疗效的观察[J]. 山东大学耳鼻喉眼学报, 2020, 34(2): 57-60.
[11]	张俊军,刘海莉,刘加福,秦小奉,杜洪明,王厚慧. 糖皮质激素不同给药方式治疗突发性聋的临床疗效及安全性研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 52-55.
[12]	刘建波,张环. 超声乳化联合玻璃体腔药物注射治疗白内障合并糖尿病性黄斑水肿[J]. 山东大学耳鼻喉眼学报, 2019, 33(2): 99-104.
[13]	杜经纬,冯俊,马鹏,李志勇,李红光. 鼻腔冲洗联合鼻用糖皮质激素对AR患者FeNO、肺功能及生活质量的影响[J]. 山东大学耳鼻喉眼学报, 2019, 33(1): 124-127.
[14]	黄凯丰. 糖皮质激素短疗程雾化吸入对嗜酸粒细胞性鼻窦炎伴鼻息肉患者鼻部症状及肾上腺皮质功能的影响[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 28-31.
[15]	李华斌, 赖玉婷. 慢性鼻-鼻窦炎的发病机制及诊疗进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 4-9.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed