mTOR通路在耳蜗中的研究进展

doi:10.6040/j.issn.1673-3770.0.2023.448

摘要/Abstract

摘要： 耳聋一直是临床上的治疗难题,随着社会老龄化不断加重,耳聋患者的数量逐年递增,耳聋严重影响患者的生活质量并加重了社会负担。找到关键的干预靶点,对于耳聋的预防和治疗意义重大。mTOR位于细胞生长、代谢、增殖和存活等过程的中心位置。近来,mTOR通路在耳蜗中的作用受到了广泛关注。最新的研究表明,mTOR通路在内耳毛细胞和螺旋神经元的增殖分化、功能维持、衰老及存活中均发挥着重要作用,而内耳毛细胞和螺旋神经元是听觉形成中的关键环节,因此,mTOR信号有希望成为耳聋新的治疗靶点。论文对mTOR通路在耳蜗中的研究现状进行梳理,总结mTOR通路在耳蜗中的调控机制,并探讨该领域未来仍需解决的问题及可能的研究方向。

关键词: mTOR, 耳聋, 毛细胞, 细胞死亡

Abstract: Deafness, a growing clinical challenge exacerbated by societal aging, increasingly affects patients' quality of life and adds to the social burden. Identifying effective intervention targets is crucial for the prevention and treatment of deafness. mTOR (target protein of rapamycin) is central to the processes of cell growth, metabolism, proliferation, and survival. Recent studies suggest that the mTOR pathway is essential for the proliferation, differentiation, maintenance, aging, and survival of cochlear inner ear hair cells and spiral neurons, which are essential for hearing. This paper reviews current research on the mTOR pathway in the cochlea, summarizes its regulatory mechanisms, and discusses unresolved issues and potential future research directions, highlighting the promise of mTOR as a novel therapeutic target for deafness.

中图分类号:

R764.43

李钰,刘皓,王敏,付小龙,李文. mTOR通路在耳蜗中的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 112-118.

LI Yu, LIU Hao, WANG Min, FU Xiaolong, LI Wen. Research progress on mTOR signaling pathway in cochlea[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 112-118.

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