细胞焦亡在老年退行性疾病中的研究进展

doi:10.6040/j.issn.1673-3770.0.2022.090

摘要/Abstract

摘要： 细胞焦亡是一种主要通过炎症小体诱导炎性半胱氨酸天冬氨酸特异性蛋白酶家族激活进而切割焦亡蛋白Gasdermin家族,最终导致细胞膜成孔破裂释放细胞内容物引起强烈炎症反应的新型程序性细胞死亡方式。已有关于细胞焦亡通路的报道主要包括Caspase-1依赖的经典细胞焦亡通路、Caspase-11依赖的非经典的细胞焦亡通路、Caspase-3依赖的GSDME细胞焦亡通路及Caspase-8依赖的GSDMD细胞焦亡通路,而在这多条细胞焦亡信号通路中炎症小体与焦亡蛋白Gasdermins分别作为先行兵和执行者发挥着重要作用。近几年,随着老年化时代的到来,细胞焦亡在老年退行性疾病中的研究也成为热点。论文主要综述细胞焦亡的主要机制及其在老年性耳聋、年龄相关性黄斑变性、阿尔兹海默病等老年退行性疾病中的研究进展。

关键词: 细胞焦亡, 炎症小体, Gasdermin家族, 老年性耳聋, 年龄相关性黄斑变性, 阿尔兹海默病

Abstract: Pyroptosis is a process that mainly induces the activation of the inflammatory cysteine-aspartate-specific protease family through the inflammasome and subsequently cleaves the gasdermin family of pyroptotic proteins. This eventually leads to the rupture of cell membranes and release of cell contents, causing an intense novel programmed cell death mode of inflammatory responses. Currently reported pyroptosis pathways mainly include the caspase-1-dependent classical, caspase-11-dependent non-classical, caspase-3-dependent gasdermin E, and caspase-8-dependent gasdermin D pyroptosis pathways. In these multiple pyroptotic signaling pathways, the inflammasome and pyroptotic protein, gasdermins, play important roles as pioneers and executors. In recent years, with the advent of the aging era, research on pyroptosis in senile degenerative diseases has attracted attention. This article mainly reviews the main mechanism of pyroptosis and its research progress in senile degenerative diseases such as presbycusis, age-related macular degeneration, and Alzheimer's disease.

Key words: Pyroptosis, Inflammasome, Gasdermin family, Presbycusis, Age-related macular degeneration, Alzheimer's disease

中图分类号:

R764.43+6

周加敏,宋玉婉,孙岩. 细胞焦亡在老年退行性疾病中的研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(4): 172-180.

ZHOU Jiamin, SONG Yuwan, SUN Yan. Research progress of pyroptosis in senile degenerative diseases[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 172-180.

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