重组人p53腺病毒注射液（今又生）联合放疗治疗复发性鼻咽癌疗效观察

山东大学耳鼻喉眼学报 ›› 2010, Vol. 24 ›› Issue (5): 13-16.

重组人p53腺病毒注射液（今又生）联合放疗治疗复发性鼻咽癌疗效观察

刘蓉蓉，姬长友，陈继川

第三军医大学大坪医院野战外科研究所耳鼻咽喉-头颈外科，重庆 400042

收稿日期:2010-01-27 修回日期:2010-06-22 出版日期:2010-10-16 发布日期:2010-10-16
作者简介:刘蓉蓉，女，主治医师，主要从事耳鼻喉疾病的临床研究。Email: rongrongliu123@126.com

Clinical effect of recombinant human p53 adv injection (gendicine) in combination with radiotherapy in patients suffering from recurrent nasopharyngeal carcinoma

LIU Rong-rong， JI Chang-you， CHEN Ji-chuan

Department of Otorhinolaryngology & Head and Neck Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China

Received:2010-01-27 Revised:2010-06-22 Online:2010-10-16 Published:2010-10-16

摘要/Abstract

摘要：

目的观察重组人p53腺病毒注射液联合放疗治疗复发性鼻咽癌的疗效及不良反应。方法以我院2005年1月至2006年12月期间收治的30例复发性鼻咽癌患者为研究对象。用非随机分组法将研究对象分为两组：实验组（15例），采用重组人p53腺病毒注射液肿瘤局部多点注射联合放疗；对照组（15例），采用经典放化同步治疗，分别于首次治疗后8周、6月、12月各随访1次，观察两组的疗效差异。通过CT测量肿瘤最大长径以确定肿瘤大小变化，并采用卡氏评分法评估患者生存质量。结果重组人p53腺病毒注射液联合放疗对复发性鼻咽癌疗效满意，治愈率达20%，临床获益率为100%，除发热外，无其他严重不良反应，疗效及患者生存质量均明显优于放化同步治疗。结论重组人p53腺病毒注射液联合放疗治疗复发性鼻咽癌安全、有效。

关键词: 重组人p53腺病毒注射液；放射治疗；鼻咽肿瘤

Abstract:

Objective To evaluate the therapeutic effect of and adverse reaction of recombinant human p53 adv injection (gendicine) in combination with radiotherapy in patients suffering from recurrent nasopharyngeal carcinoma. Methods A total of 30 intermittent patients with diagnoses of recurrent nasopharyngeal carcinoma from January 2005 to December 2006 were included in this study, of which 15 cases received treatment of gendicine in combination with radiotherapy(the experimental group), and the other 15 cases were given typical chemotherapy and radiotherapy (the control group). All patients were followed-up on week 8, month 6, and month 12 after the first therapy. The therapeutic effect was evaluated by the change of tumor size and living quality measured by CT and Karnofsky Score, respectively. Results The curative rate of the 5 patients treated by gendicine reached 20%, and the total effective rate was 100%, and except of fever, no other obvious adverse reaction was observed. Both the therapeutic effect and adverse reaction of gendicine were advanced compared with typical chemotherapy in combination with radiotherapy. Conclusion Gendicine in combination with radiotherapy is effective and safe for most patients with recurrent nasopharyngeal carcinoma.

Key words: Recombinant human p53 adv injection; Radiotherapy; Nasopharyngeal carcinoma

中图分类号:

R739.6

刘蓉蓉，姬长友，陈继川. 重组人p53腺病毒注射液（今又生）联合放疗治疗复发性鼻咽癌疗效观察[J]. 山东大学耳鼻喉眼学报, 2010, 24(5): 13-16.

LIU Rong-rong， JI Chang-you， CHEN Ji-chuan. Clinical effect of recombinant human p53 adv injection (gendicine) in combination with radiotherapy in patients suffering from recurrent nasopharyngeal carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(5): 13-16.

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