JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 31-35.doi: 10.6040/j.issn.1673-3770.0.2015.318

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Effect of NLRP3 inflammasome in the pathogenesis and relapse of eosinophilic nasal polyps.

DU Zhihong1, YU Yafeng2.   

  1. 1. Department of Otorhinolaryngology, Gaochun Peoples Hospital, Nanjing 211300, Jiangsu, China;2. Department of Otorhinolaryngology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China
  • Received:2015-08-02 Online:2016-02-16 Published:2016-02-16

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Abstract: Objective To explore the possible effect and mechanism of NLRP3 inflammasome in the pathogenesis and relapse of eosinophilic nasal polyps(ENP). Methods According to HE staining, the nasal polyp tissues from 80 cases of ENP(ENP group)and 24 cases of recurrent essinophilic nasal polyps(RENP, RENP group)as well as middle turbinate mucosa from 30 cases of deviated nasal septum(control group)were selected. The number of eosinophil(EOS)infiltration in all patients was detected and observed by HE staining. The immunohistochemistry was used to detect the expression of NLRP3 inflammasome, IL-1β and IL-18 in three groups, and the correlation between NLRP3 inflammasome and the number of EOS infiltration was analyzed in ENP and RENP groups. Results The expression of IL-1β and IL-18 in both ENP and RENP groups was higher than in control group(P<0.05), but no significant difference was presented between ENP group and RENP group(P>0.05). The expression of NLRP3 inflammasome in RENP group was higher significantly than in ENP group and control group(P<0.01), and the number of EOS infiltration more than ENP group(P<0.05)and control group(P<0.01). The expression of NLRP3 inflammasome in both ENP and RENP groups positively correlated with the number of EOS infiltration. Conclusion NLRP3 inflammasome, IL-1β and IL-18 were all associated with the pathogenesis of ENP closely, and NLRP3 inflammasome may involve in the relapse of ENP.

Key words: Eosinophil, NLRP3 inflammasome, Nasal polyps, Recurrent

CLC Number: 

  • R765.2
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