Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 76-80.doi: 10.6040/j.issn.1673-3770.0.2018.423

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Clinical significance and correlation between MIF and GSK-3β expression in laryngeal squamous cell carcinoma

ZOU Liangyu1, LI Lianhe2, YUE Wenhui2, HAN Zhipeng3, ZHANG Zihui3   

  1. Department of Otolaryngology, Chaoyang Central Hospital, Chaoyang 122000, Liaoning, China;
    3. Department of Pathology, Chaoyang Central Hospital, Chaoyang 122000, Liaoning, China
  • Published:2019-03-28

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Abstract: Objective To investigate the clinical significance and correlation of macrophage migration inhibitory factor(MIF)and glycogen synthase kinase-3(GSK-3β)expression in laryngeal squamous cell carcinoma. Methods The expression of MIF and GSK-3β in cancerous tissues and corresponding non-cancerous tissues of 30 patients with laryngeal squamous cell carcinoma were examined by immunohistochemistry and compared with mucosal tissues from 10 patients without laryngeal squamous cell carcinoma. The relationship between MIF and GSK-3β expression in laryngeal tissue and the clinicopathological factors of patients was analyzed. The correlation between MIF and GSK-3β expression in laryngeal squamous cell carcinoma was also investigated. Results The expression rates of MIF in laryngeal carcinoma tissues, adjacent tissues and non-cancerous laryngeal mucosa were 73.33%, 40.00%, 20.00%, respectively. The expression rates of GSK-3β in the three tissue types mentioned above were 70.00%, 13.33%, and 20.00%, respectively. MIF and GSK-3β expression were correlated with tumor differentiation, TNM stage and lymph node metastasis, but not associated with age, gender, smoking history or drinking history (P>0.05). MIF and GSK-3β expression were also correlated with each other (r=0.592, P=0.003). Conclusion Increased MIF and GSK-3β expression can occur in laryngeal squamous cell carcinoma and in laryngeal squamous cell carcinoma disease progression. MIF and GSK-3β may be used as potential biomarkers for laryngeal cancer and as indicators of progression and prognosis during observation and monitoring of laryngeal cancer patients.

Key words: Laryngeal neoplasms, Macrophage migration inhibitory factor, Glycogen synthase kinase-3, Biomarkers

CLC Number: 

  • R767
[1] 黄兆选,汪吉宝,孔维佳, 等.实用耳鼻咽喉头颈外科学[M].北京:人民卫生出版社, 2008: 488-493.
[2] Guo T, Califano JA. Molecular biology and immunology of head and neck cancer[J]. Surg Oncol Clin N Am, 2015, 24(3): 397-407. doi: 10.1016/j.soc.2015.03.002.
[3] Chang KP, Lin SJ, Liu SC, et al. Low-molecular-mass secretome profiling identifies HMGA2 and MIF as prognostic biomarkers for oral cavity squamous cell carcinoma[J]. Sci Rep, 2015, 5: 11689. doi: 10.1038/srep11689.
[4] Mishra R, Nagini S, Rana A. Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression[J]. Mol Cancer, 2015, 14: 20. doi: 10.1186/s12943-015-0300-x.
[5] Goto H, Kawano K, Kobayashi I, et al. Expression of cyclin D1 and GSK-3beta and their predictive value of prognosis in squamous cell carcinomas of the tongue[J]. Oral Oncol, 2002, 38(6): 549-556.
[6] Gao SG, Li SG, Duan XX, et al. Inhibition of glycogen synthase kinase 3 beta(GSK3β)suppresses the progression of esophageal squamous cell carcinoma by modifying STAT3 activity[J]. Mol Carcinog, 2017, 56(10): 2301-2316. doi: 10.1002/mc.22685.
[7] Park H, Lee M, Kim DW, et al. Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis[J]. Obstet Gynecol Sci, 2016, 59(6): 470. doi: 10.5468/ogs.2016.59.6.470.
[8] Kaidanovich-Beilin O, Woodgett JR. GSK-3: functional insights from cell biology and animal models[J]. Front Mol Neurosci, 2011, 4: 40. doi: 10.3389/fnmol.2011.00040.
[9] Leis H, Segrelles C, Ruiz S, et al. Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis[J]. Mol Carcinog, 2002, 35(4): 180-185. doi: 10.1002/mc.10087.
[10] Liu RM, Sun DN, Jiao YL, et al. Macrophage migration inhibitory factor promotes tumor aggressiveness of esophageal squamous cell carcinoma via activation of Akt and inactivation of GSK3β[J]. Cancer Lett, 2018, 412: 289-296. doi:10.1016/j.canlet.2017.10.018.
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