Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (2): 139-143.doi: 10.6040/j.issn.1673-3770.0.2021.052

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Tetrandrine regulates autophagy in tumor cells

YAO Zhouzhou   

  1. ZHANG Gehua, CHANG LihongGuidanceDepartment of Otorhinolaryngology & Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, Guangdong, China
  • Published:2022-04-15

Abstract: Autophagy is a highly conserved cellular process mediated by lysosomes, which is important to maintain cell homeostasis. It is closely related to the occurrence and development of many diseases and plays a dual role in tumor.Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the traditional Chinese medicine, exhibits the antitumor activity with multiple bioactivities in vivo and in vitro. Recently, the activity of tetrandrine in regulating autophagy has attracted much attention. This paper reviews the research progress of tetrandrine in the regulation of tumor autophagy in recent 10 years to provide a new way in the use of tetrandrine as an antitumor drug.

Key words: Tetrandrine, Autophagy, Dibenzylisoquinoline alkaloids, Lysosome, Tumour

CLC Number: 

  • R730
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