Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (5): 93-99.doi: 10.6040/j.issn.1673-3770.0.2021.203

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Progress in diabetic retinopathy mechanisms and cellular models

WANG Jiaojiao, LI MiaoOverview,SONG ZongmingGuidance   

  1. Department of Ophthalmology, Henan Provincial People's Hospital/Henan Eye Hospital/Henan Eye Institute, Zhengzhou 450003, Henan, China
  • Published:2022-09-20

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Abstract: Diabetic retinopathy is the leading cause of poor vision and blindness in adults. A reasonable model for diabetic retinopathy can not only simulate its pathogenic mechanism, but also reduce economic investment. Therefore, screening and constructing suitable cell models is the core of research. In this paper, the mechanisms of inflammatory response, apoptosis, vascular dysfunction, and neurovascular unit dysfunction in diabetic retinopathy were discussed. Moreover, several models of endothelial cells, pericytes, retinal pigment epithelial cells, and glial cells were summarized to provide a useful reference for further studies on the mechanism of diabetic retinopathy and the development of relevant drugs.

Key words: Diabetic retinopathy, Vitro model, Construct, Mechanism, Progress

CLC Number: 

  • R774
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