Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 64-70.doi: 10.6040/j.issn.1673-3770.0.2021.577

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The roles of ion channels in the pathogenesis of chronic rhinosinusitis

LIN Hai, ZHU YingOverview,ZHANG Weitian   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital/Otolaryngological Institute, Shanghai Jiao Tong University/Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai 200233, China
  • Published:2022-06-15

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Abstract: Chronic rhinosinusitis(CRS)is a common chronic inflammatory disease in rhinology; its etiology and pathogenesis are not fully understood. Ion channels are proposed to participate in a variety of physiological activities, such as stabilizing membrane potential, maintaining cellular volume homeostasis, regulating intercellular signal transduction, and other functions. Calcium channels, potassium channels, sodium channels, chloride channels and hydrogen ion-related ion channels are closely related to the pathogenesis of CRS. Numerous studies have shown that ion channels are abnormally expressed in nasal mucosa tissues from CRS patients, indicating that disturbance of ion channel regulation may be involved in the inflammatory immune response of CRS and lead to its further aggravation. This review summarizes research progress on the roles of ion channels in the pathogenesis of CRS. The aim is to provide new insights into further explorations of CRS pathogenesis and treatment strategies.

Key words: Chronic rhinosinusitis, Nasal polyp, Ion, Ion channels, Pathogenesis

CLC Number: 

  • R765.41
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