中成药治疗急性咽炎数据挖掘及网状Meta分析

doi:10.6040/j.issn.1673-3770.0.2022.173

Abstract

Abstract: Objective This study aimed to explore the use of Chines- patent medicines in managing patients with acute pharyngitis, and to compare their efficacy against commonly used drugs. Methods Clinical studies of Chinese-patent medicines for acute pharyngitis, published until April 20, 2022, were collected from PubMed, Embase, Cochrane Library, web of science, CNKI, Wanfang, Sinomed, and VIP. Meta-analysis and data mining were done with the Stata software and R software. Results A total of 202 clinical studies and 141 types of Chinese-patent medicines were collected. Of which, a watermelon cream preparation was the most frequently studied Chinese-patent medicine, followed by Shufengjiedu capsules. The main symptoms of exuberant lung-stomach heat included sore swollen throat, dry throat and thirst, and gum swelling and pain. On the other hand, the main symptoms of wind-heat assailing the outer body included pharyngeal redness and swelling, dry throat, hoarseness, hissing, and fever. A total of 33 randomized control trials, 14 interventions, and eight types of Chinese-patent medicines were included in our meta-analysis, which showed that Sufengjiedu capsules combined with antibiotics, watermelon cream preparation, Qingyan drops combined with antibiotics, Guaizijin, and Yinhuang preparations were more effective than single vse antibiotics. Moreover, our net meta-analysis revealed that the Yinhuang preparation(SUCRA=0.87), sufengjiedu capsule combined with antiviral drugs(SUCRA=0.85), and watermelon cream preparation(SUCRA=0.72)had the greatest efficiency rates. Conclusion At present, the most used clinical research on the treatment of acute pharyngitis with Chinese-patent medicine involves the use of watermelon cream preparation. The most common pattern is wind-heat assailing the outer body. Our metanalysis revealed that the efficacy of Chinese patent medicines was non-inferior to that of antibiotics alone. Of which, the Yinhuang preparation displayed the best efficacy.

Key words: Acute pharyngitis, Chinese patent medicine, Meta-analysis, Data mining

CLC Number:

R766.14

LI Zepeng, LI Wenjian, SUN Zhijia. Net Meta-analysis and data mining of patients with acute pharyngitis managed with Chinese medicine[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 111-118.

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Net Meta-analysis and data mining of patients with acute pharyngitis managed with Chinese medicine

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