Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (1): 70-74.doi: 10.6040/j.issn.1673-3770.0.2021.117

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Short-term effect of Dermatophagoides farinae specific sublingual immunotherapy for children with allergic rhinitis

PANG Chong1, BIAN Sainan2,3,4, ZHANG Bing1, YIN Xu1, LU Yingxia1, YE Pengfei1, WANG Zhan1, ZHAO Jing1, GAO Yan1, GUAN Kai2,3,4   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Capital Institute of Pediatrics affiliated Children's Hospital, Beijing, 100730, China;
    2. Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China;
    3. Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, Beijing, 100730, China;
    4. National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, China
  • Published:2022-02-22

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Abstract: Objective To evaluate the short-term effect of Dermatophagoides farinae specific sublingual immunotherapy for children with allergic rhinitis. Methods Children attended in the department of otorhinolaryngology head and neck surgery, Capital Institute of Pediatrics affiliated Children's Hospital and received Dermatophagoides farinae specific sublingual immunotherapy for 6 months were enrolled from 2019 to 2020. Visual analogue scale(VAS), total nasal symptoms score(TNSS), total medication score(TMS), and combined symptom and medication score(CSMS)before and after immunotherapy were collected. Results In total 50 children with allergic rhinitis were enrolled, with an average age of(7.7±2.7)years old. Before immunotherapy, VAS, TNSS, TMS and CSMS was(5.5±1.6)score,(5.5±2.2)score,(3.0±0.1)score,(4.3±0.6)score, respectively. And after immunotherapy for 6 months, VAS, TNSS, TMS and CSMS was(2.5±1.4)score,(2.2±1.6)score,(0.6±1.1)score,(1.2±1.2)score, respectively. The scores were all decreased significantly after immunotherapy(P<0.05). Conclusion Short term efficacy of Dermatophagoides farinae specific sublingual immunotherapy is good for children with allergic rhinitis.

Key words: Allergic rhinitis, Dermatophagoides farinae, Sublingual immunotherapy

CLC Number: 

  • R765
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