中医药治疗变应性鼻炎疗效的生物标志物研究进展

Research progress on biomarkers of traditional Chinese medicine in the treatment of allergic rhinitis

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doi:10.6040/j.issn.1673-3770.0.2023.020

Abstract: Allergic rhinitis(AR)is a common disease in otolaryngology. It is characterized by nasal itching, paroxysmal sneezing, runny nose, and nasal congestion. The incidence rate has been gradually increasing and it has become a major chronic inflammatory disease of the respiratory tract. Traditional Chinese medicine(TCM)treatment can not only effectively control the symptoms of patients with AR, but also has preventive and long-term effects. At present, the evaluation of efficacy is still based on the symptom, which are subjective. Therefore, biological indicators that can objectively evaluate the efficacy are needed with urgency. This paper reviews the relevant recent literature on the biological markers of the efficacy of TCM in the treatment of AR. We show that the changes in various cytokines and immune cells in nasal secretions and serum immunological indexes are related to the mechanism of TCM in the treatment of AR. Therefore, they can be used as potential biomarker to evaluate the efficacy of TCM, and provide evidence-base for the treatment of allergic rhinitis with TCM.

Key words: Traditional Chinese medicine, Allergic rhinitis, Biomarkers, Nasal secretions, Serum immunology, Respiratory chronicity

CLC Number:

R765.21

ZHOU Heqing, SHEN Qi. Research progress on biomarkers of traditional Chinese medicine in the treatment of allergic rhinitis[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 168-176.

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