Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (6): 106-111.doi: 10.6040/j.issn.1673-3770.0.2023.170

• Clinical Study • Previous Articles     Next Articles

Metabolic markers in obstruetive sleep apnea hypopnea syndrome patients with different arousal thresholds

XING Liang, YUAN Yuqi, XIE Yushan, SU Yonglong, NIU Xiaoxin, MA Lina, WANG Zitong, LIU Haiqin, SHI Yewen, REN Xiaoyong   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China
  • Published:2023-12-15

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Abstract: Objective This study aimed to investigate variations in clinical characteristics among patients with obstructive sleep apnea hypopnea syndrome(OSAHS)who exhibit different arousal thresholds and to analyze the correlation between arousal thresholds and clinical factors. Methods We selected 107 adult male patients diagnosed with OSAHS by polysomnography(PSG)from September 2018 to June 2022. The patients were categorized based on their arousal threshold scores and underwent arterial blood gas and biochemical examinations. We compared the PSG parameters, arterial blood gas, dyslipidemia, and fasting plasma glucose. Linear regression was used to estimate the association between significant variables and arousal threshold after adjusting for apnea hypopnea index(AHI). Additionally, we analyzed the correlation between arousal threshold and specific clinical factors. Results The high arousal threshold group had higher AHI, apnea index(AI), longest apnea time(LAT)and mean apnea time(MAT), oxygen desaturation index(ODI), percentage of total sleep time with oxygen saturation below 90%, total cholesterol(TC), and low-density lipoprotein cholesterol(LDL-C)compared to the low arousal threshold group. Conversely, the low arousal threshold group had higher values for the lowest oxygen saturation(LSaO2)and mean oxygen saturation(MSaO2)during sleep compared to the high arousal threshold group. However, both TC and LDL-C showed no correlation with arousal threshold after adjusting for AHI. Furthermore, the arousal threshold score was negatively correlated with AHI, AI, LAT and MAT, and positively correlated with LSaO2 and MSaO2. Conclusion Patients with OSAHS who had different arousal threshold showed changes in lipid metabolism, which may be potential biomarkers of metabolic disorders in such patients.

Key words: Obstructive sleep apnea hypopnea syndrome, Arousal threshold, Arterial blood gas, Dyslipidemia

CLC Number: 

  • R766
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