Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (6): 85-92.doi: 10.6040/j.issn.1673-3770.0.2023.174

• Clinical Study • Previous Articles     Next Articles

Clinical significance of peripheral blood inflammatory markers in obstructive sleep apnea hypopnea syndrome with hypertension

YUAN Yuqi, CAO Zine, NIU Xiaoxin, XIE Yushan, SU Yonglong, ZHU Simin, ZHANG Yitong, LIU Haiqin, REN Xiaoyong, SHI Yewen   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China
  • Published:2023-12-15

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Abstract: Objective To assist with evaluating the patient's condition, we investigated peripheral blood inflammatory marker changes in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)complicated with hypertension. Methods We retrospectively analyzed data from 196 patients with OSAHS diagnosed by polysomnography(PSG). The patients were divided into the simple OSAHS(150 cases)or the OSAHS with hypertension(46 cases)groups. The following inflammatory indexes were calculated: neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), monocyte-to-lymphocyte ratio(MLR), and the systemic immune-inflammation index(SII). The differences of the basic clinical data, PSG parameters, and inflammatory indexes were compared between the two groups. The inflammatory indexes and blood pressure were also correlated. Regression analysis of the variables associated with blood pressure was conducted. Results Considering the inflammatory markers, the NLR, PLR, and SII levels in patients with OSAHS and hypertension were significantly higher than those with only OSAHS(P=0.007; P=0.032; P=0.009). Correlation analysis showed that systolic blood pressure in patients with OSAHS was positively correlated with the body mass index(BMI), apnea-hypopnea index(AHI), NLR, and SII(r=0.195, P=0.006; r=0.195, P=0.006; r=0.208, P=0.004; r=0.246, P=0.001, respectively), and negatively correlated with the lowest oxygen saturation(LSaO2; r=-0.228, P=0.001). The diastolic blood pressure in patients with OSAHS was also positively correlated with BMI, AHI, NLR, and SII(r=0.160, P=0.025; r=0.210, P=0.003; r=0.145, P=0.043; r=0.206, P=0.004, respectively), and negatively correlated with LSaO2(r=-0.203, P=0.004). Binary logistic regression analysis showed that age and SII were independent risk factors for the patients with OSAHS and hypertension. Systolic blood pressure and diastolic blood pressure were considered in the multiple linear regression as dependent variables. The results suggest that the longest hypopnea time and SII were risk factors for blood pressure in patients with OSAHS. Conclusion NLR and SII significantly increased in patients with OSAHS and hypertension and were also significantly associated with blood pressure. Thus, clinical monitoring of the above indicators may assist in evaluating the patient's condition.

Key words: Obstructive sleep apnea hypopnea syndrome, Hypertension, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Monocyte-to-lymphocyte ratio, The systemic immune-inflammation index

CLC Number: 

  • R766.4
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