阻塞性睡眠呼吸暂停与抑郁症共病机制的研究进展

doi:10.6040/j.issn.1673-3770.0.2024.513

Abstract

Abstract: Obstructive sleep apnea(OSA)is a common sleep-related breathing disorder. Depression, also known as depressive disorder, is a prevalent mental disorder. OSA and depression interact with each other. Patients with OSA have a higher prevalence of depression, as poor sleep structure, daytime fatigue and complaints from others about snoring negatively affect the mood of OSA patients; patients with depression frequently experience sleep disturbances, which may increase the risk of OSA through abnormal neurotransmitter levels and altering muscle tone. Moreover, co-occurrence of these disorders often manifests as more severe symptomatology and complex therapeutic challenges. Shared pathophysiological mechanisms include neuroinflammation, oxidative stress, gut microbiota dysbiosis, impaired synaptic plasticity, lower 5-HT levels, and complement activation. These mechanisms interact in the occurrence and development of OSA and depression, and jointly promote the progression of the disease. In this paper, we summarize the epidemiology, pathogenesis, and treatment of OSA and depression comorbidity, aiming to deepen the understanding of the two co-comorbidities and to provide scientific support for precise treatment of patients.

Key words: Obstructive sleep apnea, Depression, Comorbidity, Neuroinflammation

CLC Number:

R766

LI Lilin, LI Xinyi, GUAN Jian. Research progress on the mechanism of comorbidity between obstructive sleep apnea and depression[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 89-96.

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