ISSN 1673-3770 CN 37-1437/R
Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (6): 62-67.doi: 10.6040/j.issn.1673-3770.0.2022.096
• Research Progress • Previous Articles Next Articles
ZHU Yaxin,LIU Feng,GUAN Jian,YIN Shankai
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| [1] Perry M, Whyte A. Immunology of the tonsils[J]. Immunol Today, 1998, 19(9): 414-421. doi:10.1016/s0167-5699(98)01307-3 [2] 宋晓蕊, 许莹, 僧东杰, 等. 腺样体和扁桃体菌群研究进展[J]. 中华耳鼻咽喉头颈外科杂志, 2021, 56(8): 885-890. doi:10.3760/cma.j.cn115330-20201009-00792 SONG Xiaorui, XU Ying, SENG Dongjie, et al. Advances in adenotonsillar microbiome[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2021, 56(8): 885-890. doi:10.3760/cma.j.cn115330-20201009-00792 [3] Cho KS, Kim SH, Hong SL, et al. Local atopy in childhood adenotonsillar hypertrophy[J]. Am J Rhinol Allergy, 2018, 32(3): 160-166. doi:10.1177/1945892418765003 [4] Lumeng JC, Chervin RD. Epidemiology of pediatric obstructive sleep apnea[J]. Proc Am Thorac Soc, 2008, 5(2): 242-252. doi:10.1513/pats.200708-135MG [5] Leitzen KP, Brietzke SE, Lindsay RW. Correlation between nasal anatomy and objective obstructive sleep apnea severity[J]. Otolaryngol Head Neck Surg, 2014, 150(2): 325-331. doi:10.1177/0194599813515838 [6] 刘燕,魏萍,寇巍,等. 儿童腺样体肥大与耳鼻咽喉科常见疾病关系的研究进展[J]. 山东大学耳鼻喉眼学报,2019, 33(4): 149-154. doi:10.6040/j.issn.1673-3770.0.2018.266 LIU Yan, WEI Ping, KOU Wei, et al. Research of the relationship between adenoid hypertrophy and the common diseases of pediatric otolaryngology[J]. Journal of Otolaryngology and Ophthalmology of Shandong University,2019, 33(4): 149-154. doi:10.6040/j.issn.1673-3770.0.2018.266 [7] 李延忠, 张泰. 关于儿童阻塞性睡眠呼吸暂停低通气综合征我们面临的问题[J]. 山东大学耳鼻喉眼学报,2018, 32(2): 1-5. doi:10.6040/j.issn.1673-3770.1.2018.003 LI Yanzhong, ZHANG Tai. Problems we face in children with obstructive sleep apnea hypopnea syndrome[J]. Journal of Otolaryngology and Ophthalmology of Shandong University,2018, 32(2): 1-5. doi:10.6040/j.issn.1673-3770.1.2018.003 [8] 中国儿童OSA诊断与治疗指南制订工作组, 中华医学会耳鼻咽喉头颈外科学分会小儿学组, 中华医学会儿科学分会呼吸学组,等.中国儿童阻塞性睡眠呼吸暂停诊断与治疗指南(2020)[J].中华耳鼻咽喉头颈外科杂志,2020,55(8): 729-747. doi: 10.3760/cma.j.cn115330-20200521-00431 Working Group of Chinese Guideline for the Diagnosis and Treatment of Childhood OSA, Subspecialty Group of Pediatrics, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association, Subspecialty Group of Respiratory Diseases, Society of Pediatrics, Chinese Medical Association, et al.Chinese guideline for the diagnosis and treatment of childhood obstructive sleep apnea(2020)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2020, 55(8): 729-747. doi:10.3760/cma.j.cn115330-20200521-00431 [9] 许政敏, 付勇, 沈翎,等. 儿童反复上呼吸道感染临床诊治管理专家共识[J]. 中国实用儿科杂志, 2017, 32(10): 721-725. doi:10.19538/j.ek2017100601 XU Zhengmin, FU Yong, Shen Ling, et al. Chinese Journal of Practical Pediatrics[J]. Chinese Journal of Practical Pediatrics, 2017, 32(10): 721-725. doi:10.19538/j.ek2017100601 [10] Bitar MA, Saade R. The role of OM-85 BV(Broncho-Vaxom)in preventing recurrent acute tonsillitis in children[J]. Int J Pediatr Otorhinolaryngol, 2013, 77(5): 670-673. doi:10.1016/j.ijporl.2013.01.009 [11] 于清波. OM85-BV治疗儿童反复上呼吸道感染伴腺样体肥大的效果及对血清TNF-α、IL-6、sIL-2R水平的影响[J]. 中国医学创新, 2022, 19(4): 8-12. doi:10.3969/j.issn.1674-4985.2022.04.002 YU Qingbo. Effect of OM85-BV in the treatment of children with recurrent respiratory tract infections with adenoid hypertrophy and its effect on serum levels of TNF-α, IL-6 and sIL-2R[J]. Medical Innovation of China, 2022, 19(4): 8-12. doi:10.3969/j.issn.1674-4985.2022.04.002 [12] 陈文欣, 曹伟, 沈佳华, 等. OM85-BV对反复上呼吸道感染伴腺样体肥大的疗效及治疗机制初步探讨[J]. 临床耳鼻咽喉头颈外科杂志, 2020, 34(6): 499-504. doi:10.13201/j.issn.2096-7993.2020.06.005 CHEN Wenxin, CAO Wei, SHEN Jiahua, et al. The efficacy of OM85-BV in the treatment of recurrent upper respiratory tract infection with adenoid hypertrophy and the preliminary exploration of potential therapeutic mechanism[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2020, 34(6): 499-504. doi:10.13201/j.issn.2096-7993.2020.06.005 [13] 中国医师协会儿科医师分会儿童耳鼻咽喉专业委员会,中国妇幼保健协会儿童变态反应专业委员会. 儿童上气道炎症性疾病联合治疗专家共识[J]. 中国实用儿科杂志, 2021, 36(12): 897-903. doi:10.19538/j.ek2021120603 Ear-Nose-Throat Committee of Chinese Association of Pediatricians;Pediatric Allergy Committee of Chinese Maternal and Child Health Association. Expert consensus on joint treatment for children with upper airway inflammation[J]. Chinese Journal of Practical Pediatrics, 2021, 36(12): 897-903. doi:10.19538/j.ek2021120603 [14] 谷婷婷,刘岩,张悦,等.内舒拿联合孟鲁司特钠治疗腺样体肥大的Meta分析[J]. 山东大学耳鼻喉眼学报,2021, 35(1): 47-55. doi:10.6040/j.issn.1673-3770.0.2020.181 GU Tingting, LIU Yan, ZHANG Yue, et al. Nasonex and montelukast sodium in the treatment of adenoidal hypertrophy: a Meta-analysis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 47-55. doi:10.6040/j.issn.1673-3770.0.2020.181 [15] Kim KS, Min HJ. Correlations between the adenotonsillar microbiome and clinical characteristics of pediatric patients with snoring[J]. Clin Exp Otorhinolaryngol, 2021, 14(3): 295-302. doi:10.21053/ceo.2020.01634 [16] Cho SW, Yang SK. What does the microbiome in the tonsil tell us? [J]. Clin Exp Otorhinolaryngol, 2021, 14(3): 247-248. doi:10.21053/ceo.2021.01074 [17] Nave H, Gebert A, Pabst R. Morphology and immunology of the human palatine tonsil[J]. Anat Embryol(Berl), 2001, 204(5): 367-373. doi:10.1007/s004290100210 [18] Saravia J, Chapman NM, Chi H. Helper T cell differentiation[J]. Cell Mol Immunol, 2019,16(7):634-643. doi:10.1038/s41423-019-0220-6 [19] 张奇雪. EOS及Th1/Th2失衡在腺样体肥大患儿中的意义研究[D]. 天津: 天津医科大学, 2019 [20] 张爱英, 史雅楠, 宋英鸾, 等. 白细胞介素-5与干扰素-γ介导的Th2/Th1失衡在腺样体肥大伴分泌性中耳炎中的研究[J]. 中国耳鼻咽喉头颈外科, 2019, 26(4): 218-219. doi:10.16066/j.1672-7002.2019.04.013 ZHANG Aiying, SHI Yanan, SONG Yingluan, et al. Chinese Archives of Otolaryngology-Head and Neck Surgery[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2019, 26(4): 218-219. doi:10.16066/j.1672-7002.2019.04.013 [21] 董家琪, 姜妍, 黄世勇, 等. 分泌性中耳炎儿童腺样体组织中IL-10、IFN-γ表达[J]. 听力学及言语疾病杂志, 2020, 28(2): 149-152. doi:10.3969/j.issn.1006-7299.2020.02.008 DONG Jiaqi, JIANG Yan, HUANG Shiyong, et al. Expression of IFN-γ and IL-10 in adenoid tissues of children with secretory otitis media[J]. Journal of Audiology and Speech Pathology, 2020, 28(2): 149-152. doi:10.3969/j.issn.1006-7299.2020.02.008 [22] Zhang XW, Sun BQ, Li S, et al. Local atopy is more relevant than serum SIgE in reflecting allergy in childhood adenotonsillar hypertrophy[J]. Pediatr Allergy Immunol, 2013, 24(5): 422-426. doi:10.1111/pai.12089 [23] Zou JJ, Yang Y, Fu Q, et al. Eosinophils are more strongly relevant to allergic sensitization than basophils in pediatric adenotonsillar hypertrophy[J]. Front Pediatr, 2021, 9: 598063. doi:10.3389/fped.2021.598063 [24] Bettelli E, Carrier Y, Gao WD, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells[J]. Nature, 2006, 441(7090): 235-238. doi:10.1038/nature04753 [25] Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases[J]. Autoimmun Rev, 2014, 13(6): 668-677. doi:10.1016/j.autrev.2013.12.004 [26] 倪坤, 赵利敏, 吴佳欐, 等. Th17/Treg在儿童腺样体肥大发病机制中的作用[J]. 中国眼耳鼻喉科杂志, 2016, 16(2): 103-106, 110. doi:10.14166/j.issn.1671-2420.2016.02.010 NI Kun, ZHAO Limin, WU Jiali, et al. Role of Th17/Treg balance in the pathogenesis of adenoidal hypertrophy in children[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2016, 16(2): 103-106, 110. doi:10.14166/j.issn.1671-2420.2016.02.010 [27] Vinuesa CG, Linterman MA, Yu D, et al. Follicular helper T cells[J]. Annu Rev Immunol, 2016, 34: 335-368. doi:10.1146/annurev-immunol-041015-055605 [28] Feng CY, Zhang QC, Zhou GQ, et al. Roles of T follicular helper cells in the pathogenesis of adenoidal hypertrophy combined with secretory otitis media[J]. Medicine, 2018, 97(13): e0211. doi:10.1097/MD.0000000000010211 [29] Carrasco A, Sjölander I, van Acker A, et al. The tonsil lymphocyte landscape in pediatric tonsil hyperplasia and obstructive sleep apnea[J]. Front Immunol, 2021, 12: 674080. doi:10.3389/fimmu.2021.674080 [30] Matsumiya H, Kawata K, Kamekura R, et al. High frequency of Bob1 lo T follicular helper cells in florid reactive follicular hyperplasia[J]. Immunol Lett, 2017, 191: 23-30. doi:10.1016/j.imlet.2017.07.012 [31] Cyster JG, Allen CDC. B Cell Responses: Cell Interaction Dynamics and Decisions. Cell. 2019;177(3):524-540. Doi:10.1016/j.cell.2019.03.016 [32] Zhang PC, Pang YT, Loh KS, et al. Comparison of histology between recurrent tonsillitis and tonsillar hypertrophy[J]. Clin Otolaryngol Allied Sci, 2003, 28(3): 235-239. doi:10.1046/j.1365-2273.2003.00697.x [33] Sarmiento Varon L, de Rosa J, Machicote A, et al. Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy[J]. Sci Rep, 2017, 7(1): 11077. doi:10.1038/s41598-017-09689-x [34] Dan JM, Havenar-Daughton C, Kendric K, et al. Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant T FH cells[J]. Sci Transl Med, 2019, 11(478): eaau3776. doi:10.1126/scitranslmed.aau3776 [35] Vivier E, Artis D, Colonna M, et al. Innate lymphoid cells: 10 years on[J]. Cell, 2018, 174(5): 1054-1066. doi:10.1016/j.cell.2018.07.017 [36] Moro K, Yamada T, Tanabe M, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+)lymphoid cells[J]. Nature, 2010, 463(7280): 540-544. doi:10.1038/nature08636 [37] Price AE, Liang HE, Sullivan BM, et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity[J]. Proc Natl Acad Sci USA, 2010, 107(25): 11489-11494. doi:10.1073/pnas.1003988107 [38] Neill DR, Wong SH, Bellosi A, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity[J]. Nature, 2010, 464(7293): 1367-1370. doi:10.1038/nature08900 [39] 张爱英, 史雅楠, 宋英鸾, 等. Ⅱ型固有淋巴细胞相关因子在腺样体肥大伴分泌性中耳炎的研究[J]. 中国耳鼻咽喉头颈外科, 2018, 25(11): 591-593. doi:10.16066/j.1672-7002.2018.11.005 ZHANG Aiying, SHI Yanan, SONG Yingluan, et al. Research on the effect of the associated cytokine of type II innate lymphoid cells(ILC2)in otitis media with effusion with adenoid hypertrophy[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2018, 25(11): 591-593. doi:10.16066/j.1672-7002.2018.11.005 [40] Magri G, Miyajima M, Bascones S, et al. Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells[J]. Nat Immunol, 2014, 15(4): 354-364. doi:10.1038/ni.2830 [41] Wagar LE, Salahudeen A, Constantz CM, et al. Modeling human adaptive immune responses with tonsil organoids[J]. Nat Med, 2021, 27(1): 125-135. doi:10.1038/s41591-020-01145-0 [42] Johnston J, Hoggard M, Biswas K, et al. The bacterial community and local lymphocyte response are markedly different in patients with recurrent tonsillitis compared to obstructive sleep apnoea[J]. Int J Pediatr Otorhinolaryngol, 2018, 113: 281-288. doi:10.1016/j.ijporl.2018.07.041 [43] Mikola E, Elenius V, Saarinen M, et al. Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis[J]. Clin Transl Allergy, 2018, 8: 22. doi:10.1186/s13601-018-0205-z [44] de Corso E, Galli J, di Cesare T, et al. A systematic review of the clinical evidence and biomarkers linking allergy to adeno-tonsillar disease[J]. Int J Pediatr Otorhinolaryngol, 2021, 147: 110799. doi:10.1016/j.ijporl.2021.110799 |
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