Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (6): 41-45.doi: 10.6040/j.issn.1673-3770.0.2023.342

• Research Progress • Previous Articles     Next Articles

Advances in research on the relationship between obstructive sleep apnea and breast cancer

HU Tingting, WANG Yuehua   

  1. Department of oncology, Affiliated Hospital of Hubei University of Arts and Science Xiangyang Central Hospital, Xiangyang 441021, Hubei, China
  • Published:2023-12-15

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Abstract: Animal studies suggest that intermittent hypoxia due to obstructive sleep apnea(OSA)is a risk factor for breast cancer. Despite biological plausibility, human epidemiological studies have shown inconsistent results. However, a recent meta-analysis of seven large studies with a total of 5 370 466 patients showed that patients with OSA had a 36% increased risk of breast cancer compared to patients without OSA(HR 1.36, 95%CI 1.03-1.80). This article reviews the research on the relationship between OSA and breast cancer, including the possible pathogenesis of OSA-associated breast cancer.

Key words: Breast cancer, Hypoxia, Mechanism, Obstructive sleep apnea

CLC Number: 

  • R563.9
[1] Schneider AP 2nd, Zainer CM, Kubat CK, et al. The breast cancer epidemic: 10 facts[J]. Linacre Q, 2014, 81(3): 244-277. doi:10.1179/2050854914Y.0000000027
[2] Yap DWT, Tan NKW, Tan BKJ, et al. The association of obstructive sleep apnea with breast cancer incidence and mortality: a systematic review and meta-analysis[J]. J Breast Cancer, 2022, 25(3): 149. doi:10.4048/jbc.2022.25.e11
[3] Porcacchia AS, Ishikura IA, Hachul H, et al. Does obstructive sleep apnea increase the risk of breast cancer in women during and after menopause?[J]. J Clin Sleep Med, 2022, 18(3): 961-962. doi:10.5664/jcsm.9784
[4] Zhang Y, Zhang HY, Wang MH, et al. Hypoxia in breast cancer—scientific translation to therapeutic and diagnostic clinical applications[J]. Front Oncol, 2021, 11: 652266. doi:10.3389/fonc.2021.652266
[5] Almendros I, Montserrat JM, Ramirez J, et al. Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnoea[J]. Eur Respir J, 2012, 39(1): 215-217. doi:10.1183/09031936.00185110
[6] 聂帅, 崔宇杰, 刘岩, 等. 阻塞性睡眠呼吸暂停与肿瘤相关性进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(5):152-156. doi: 10.6040/j.issn.1673-3770.0.2019.595 NIE Shuai, CUI Yujie, LIU Yan, et al. Correlation between obstructive sleep apnea and tumors[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5):152-156. doi: 10.6040/j.issn.1673-3770.0.2019.595
[7] Tan BKJ, Teo YH, Tan NKW, et al. Association of obstructive sleep apnea and nocturnal hypoxemia with all-cancer incidence and mortality: a systematic review and meta-analysis[J]. J Clin Sleep Med, 2022, 18(5): 1427-1440. doi:10.5664/jcsm.9772
[8] Huang TY, Lin B, Stampfer M, et al. Associations of self-reported obstructive sleep apnea with total and site- specific cancer risk in older women: a prospective study[J]. Sleep, 2021, 44(3): 198. doi:10.1093/sleep/zsaa198
[9] Jara SM, Phipps A, Maynard C, et al. The association of sleep apnea and cancer in veterans[J]. Otolaryngol Neck Surg, 2020, 162: 581-588. doi:10.1177/0194599819900487
[10] Cheong AJY, Tan BKJ, Teo YH, et al. Obstructive sleep apnea and lung cancer: a systematic review and meta-analysis[J]. Annals ATS, 2022, 19(3): 469-475. doi:10.1513/annalsats.202108-960oc
[11] Gozal D, Ham SA, Mokhlesi B. Sleep apnea and cancer: analysis of a nationwide population sample[J]. Sleep, 2016, 39(8): 1493-1500. doi:10.5665/sleep.6004
[12] Cheng LJ, Guo H, Zhang ZL, et al. Obstructive sleep apnea and incidence of malignant tumors: a meta-analysis[J]. Sleep Med, 2021, 84: 195-204. doi:10.1016/j.sleep.2021.05.029
[13] Choi JH, Lee JY, Do Han K, et al. Association between obstructive sleep apnoea and breast cancer: the Korean National Health Insurance Service Data 2007–2014[J]. Sci Rep, 2019, 9: 19044. doi:10.1038/s41598-019-55551-7
[14] Wu DH, Zhao ZF, Chen CH, et al. Impact of obstructive sleep apnea on cancer risk: a systematic review and meta-analysis[J]. Sleep Breath, 2023, 27(3): 843-852. doi:10.1007/s11325-022-02695-y
[15] Madut A, Fuchsova V, Man H, et al. Increased prevalence of obstructive sleep apnea in women diagnosed with endometrial or breast cancer[J]. PLoS One, 2021, 16(4): 0249099. doi:10.1371/journal.pone.0249099
[16] Ozdilekcan C, Kutun S, Dogan L. Impact of obstructive sleep apnea-related symptoms on surgical wound complications in breast cancer patients: pilot study in a tertiary health center in Turkey[J].Sleep Breath, 2021, 25(2): 835-842. doi:10.1007/s11325-020-02208-9
[17] Gao XL, Jia ZM, Zhao FF, et al. Obstructive sleep apnea syndrome and causal relationship with female breast cancer: a Mendelian randomization study[J]. Aging, 2020, 12(5): 4082-4092. doi:10.18632/aging.102725
[18] 高莹慧, 田强, 李春娣, 等. 阻塞性睡眠呼吸暂停会增加某些癌症的患病率和病死率[J]. 国际呼吸杂志, 2014, 34(11): 853-855. doi:10.3760/cma.j.issn.1673-436X.2014.11.014 GAO Yinghui, TIAN Qiang, LI Chundi, et al. Obstructive sleep apnea can increase the morbidity and mortality of certain cancer[J]. International Journal of Respiration, 2014, 34(11): 853-855. doi:10.3760/cma.j.issn.1673-436X.2014.11.014
[19] Minoves M, Kotzki S, Hazane-Puch F, et al. Chronic intermittent hypoxia, a hallmark of obstructive sleep apnea, promotes 4T1 breast cancer development through endothelin-1 receptors[J]. Sci Rep, 2022, 12: 12916. doi:10.1038/s41598-022-15541-8
[20] Hunyor I, Cook KM. Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer[J]. Am J Physiol Regul Integr Comp Physiol, 2018, 315(4): R669-R687. doi:10.1152/ajpregu.00036.2018
[21] Chen AN, Sceneay J, Gödde N, et al. Intermittent hypoxia induces a metastatic phenotype in breast cancer[J]. Oncogene, 2018, 37(31): 4214-4225. doi:10.1038/s41388-018-0259-3
[22] Rausch LK, Netzer NC, Hoegel J, et al. The linkage between breast cancer, hypoxia, and adipose tissue[J]. Front Oncol, 2017, 7: 211. doi:10.3389/fonc.2017.00211
[23] Campos-Rodriguez F, Cruz-Medina A, Selma MJ, et al. Association between sleep-disordered breathing and breast cancer aggressiveness[J]. PLoS One, 2018, 13(11): e0207591. doi:10.1371/journal.pone.0207591
[24] Nieto FJ, Peppard PE, Young T, et al. Sleep-disordered breathing and cancer mortality[J]. Am J Respir Crit Care Med, 2012, 186(2): 190-194. doi:10.1164/rccm.201201-0130oc
[25] Nagaraju GP, Bramhachari PV, Raghu G, et al. Hypoxia inducible factor-1α: its role in colorectal carcinogenesis and metastasis[J]. Cancer Lett, 2015, 366(1): 11-18. doi:10.1016/j.canlet.2015.06.005
[26] Justeau G, Gervès-Pinquié C, Trzepizur W, et al. Association between nocturnal hypoxemia and cancer incidence in patients investigated for OSA-Data From a Large Multicenter French Cohort[J]. Chest, 2020, 158(6):2610-2620. doi:10.1016/j.chest.2020.06.055
[27] Palm A, Theorell-Haglöw J, Isakson J, et al. Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY cohort[J]. BMJ Open,2023,13(3): 064501.doi: 10.1136/bmjopen-2022-064501
[28] Almendros I, Gozal D. Intermittent hypoxia and cancer: undesirable bed partners?[J]. Respir Physiol Neurobiol, 2018, 256: 79-86. doi:10.1016/j.resp.2017.08.008
[29] Fietze I, Laharnar N, Obst A, et al. Prevalence and association analysis of obstructive sleep apnea with gender and age differences-Results of SHIP-Trend[J]. J Sleep Res, 2019, 28(5): 12770. doi:10.1111/jsr.12770
[30] Yang YY, Kim SC, Yu T, et al. Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses[J]. Mediators Inflamm, 2014, 2014: 352371. doi:10.1155/2014/352371
[31] Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi:10.3322/caac.21660
[32] Sillah A, Watson NF, Gozal D, et al. Obstructive sleep apnea severity and subsequent risk for cancer incidence[J]. Prev Med Rep, 2019, 15: 100886. doi:10.1016/j.pmedr.2019.100886
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