Abstract: Objective: To analyze the impact of chemotherapy on esthesioneuroblastoma and illustrate the suitable chemotherapy modality. Methods： A retrospective chart review of patients with esthesioneuroblastoma treated with chemotherapy at our department from Mar. 1993 to Jun. 2004, including age, gender, duration, Kadish staging, Hymas grade,therapy modality and outcome, was analyzed. Results： Four male cases, averagely aged 31.5 years, were treated. All patients were in Kadish C stage, and 1 in Hymas grade 2, 2 in Hymas grade 3, and 1 in Hymas grade 4. The main components of chemical drug included etoposide and platin. Chemotherapy was used as primary therapy on 1 case with grade 2, and the patient was still alive with tumor at the end of followup of 6 months. Chemotherapy was used on 3 cases as salvage therapy. Among them, 2 cases with grade 3 were alive without tumor after followups of 48 months and 6 months respectively, and 1 case with grade 4 was alive with tumor after followup of 12 months. Conclusions： Adoption of chemotherapy to treat esthesioneuroblastoma is effective, and the Hymas grade of esthesioneuroblastoma affects the response to chemotherapy. The components of chemical drug should include etoposide and platin.

Key words: Drug therapy, Platinum, Esthesioneuroblastoma, Etoposide