JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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CUI Hong1,ZHAO Shu-you1,ZHANG Qing-quan21   

  • Received:1900-01-01 Revised:1900-01-01 Online:2006-06-24 Published:2006-06-24
  • Contact: CUI Hong

Abstract: Objective: To investigate the expression of oncogene STK15 in laryngeal squamous cell carcinoma(LSCC), and therefore to find out the correlation of STK15 and laryngeal squamous cell carcinoma. Methods: SP immunohistochemical method was used to determine the expression of STK15 in 40 cases of LSCC and 30 cases of vocal cord polyp. Results: STK15 was found in 67.5%(27/40)and 33.3%(10/30)of LCSS and vocal cord polyp, the difference was significant(P<0.05). Expression of STK15 had some relation with the tumor grade and lymphatic metastasis(P<0.05), but not with the pathology grade, primary site of LSCC, patients′gender and age. The degree of STK15 expression was related with the tumor grade(P<0.05). Conclusion: STK15 may play an important role in the pathway of carcinogenesis and progression of LSCC and it may be identified as a new therapeutic target.

Key words: Carcinoma, squamous cell, Laryngeal neoplasms, Oncogene STK15, Immunohistochemistry

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