Abstract: To investigate the effect of IRIS532 overtone laser photocoagulation treatment for diabetic macular edema. Methods: A retrospective study on 45 patients (76 eyes) were analyzed. Of them, 44 eyes of localized edema were treated with direct photocoagulation and 32 eyes of diffuse edema were treated with grid photocoagulation. Vision and fundus fluorescein angiography were analyzed. Results： Among patients with localized edema, visual acuity was improved in 2 lines or more in 10 eyes (22.72%), not changed in 25 eyes(56.82%), and declined in 9 eyes(20.45%), and among patients with diffuse edema, these were respectively in 10 eyes (31.25%), 19 eyes(59.38%) and 3 eyes(9.38%). Among patients with localized edema, edema disappeared in 12 eyes(27.27%), alleviated in 23 eyes (52.27%) and did not changed in 9 eyes(20.45%), and among patients with diffuse edema, these were respectively in 6 eyes(18.75%), 14 eyes(43.75%) and 12 eyes (38.71%). Conclusion： IRIS overtone 532nm laser photocoagulation is more effective for localized edema than for diffuse edema.

Key words: Macular edema, Diabetic retinopathy, Laser coagulation