JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Expression of TRAIL and Survivin proteins in the carcinogenesis and development of laryngeal carcinoma

WU Kai, MA Mao-qiang， WANG Chun-hai, ZHANG Yong   

  1. Department of Patholgy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011, Shandong, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: WU Kai

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Abstract: Objective: To explore the correlation between the expressions of TRAIL and Survivin proteins and the pathologic features of laryngeal epithelial lesions. Methods: Immunohistochemistry was used to determine the expressions of TRAIL and Survivin proteins in normal mucosa and displasia and invasive carcinoma tissues of 48 cases of laryngeal carcinoma. Results: The expression of Survivin protein progressively increased, whereas that of TRAIL protein gradually decreased in a route of normal mucosa and displasia and invasive carcinoma tissues. The expression of TRAIL protein in laryngeal invasive carcinoma was negatively correlated with that of Survivin protein (r=-0.510, P<0.01). Conclusions: The expressions of TRAIL and Survivin proteins are significantly related to the genesis and progression of laryngeal carcinoma.

Key words: Laryngeal neoplasms, Pathology, Immunohistochemistry, Tumor necrosis factor related apoptosis inducing ligand, Survivin

CLC Number: 

  • R739.65
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