JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

• Articles • Previous Articles     Next Articles

Correlation between nuclear factor-kappa B subunit P50 activity and IL-4 and γ-IFN expressions in nasal polyps

LI Yun-qiu1, FENG Yong2, WANG Ji-hua1   

  1. Department of Otolaryngology Head and Neck Surgery, 1. Hunan Provincial Hospital, Changsha 410002, China;2. Xiangya Hospital of Central South University, Changsha 410002, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-02-24 Published:2008-02-24
  • Contact: LI Yun-qiu

PDF (PC)

1671

Abstract: To explore the possible regulatory mechanism of nuclear factorkappa B subunit P50 to Th1/Th2 cytokine in nasal polyps. MethodsThe expressions of IL-4 , γ-IFN and P50 were determined by the method of immunohistochemistry staining in 40 cases of nasal polyps and 20 normal subjects, and the linear correlations between activities of P50 and IL-4 and γ-IFN were evaluated. ResultsThe expression of P50 was mainly distributed in the cytoplasm of epithelia, inflammatory cells and the epithelia of glands, and the expression of IL-4 and the activity of P50 were significantly increased in nasal polyps(both P<0.001), however, the expression of γ-IFN had no significant differences between the groups(P>0.05). The Pearson correlation analysis demonstrated that P50 nuclear-presence closely correlated with the IL-4 level, but not with γ-IFN. The correlation coefficient was 0.70 for P50 and IL-4(P<0.001 ) and 0.14 for P50 and γ-IFN (P>0.05). ConclusionThe activity of P50 in nasal polyps significantly increases, and it may play an important role in the imbalance of Th1/Th2-typed cytokines by up-regulating the level of IL-4.

Key words: Nuclear factor κB sub-unit P50, Cytokine, Nasal polyps, IL-4, γ-IFN

CLC Number: 

  • R765.25
[1] SONG Xiaoyu, ZHANG Yu, LI Chenglin, SONG Xicheng. Enhanced recovery after surgery for the treatment of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 9-12.
[2] HUANG Yuan, BA Luo, LI Bo, YU Wenxing, YANG Fangli, DU Jintao. Transcription factor NKX2-1 regulates eosinophilic inflammation in chronic rhinosinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 17-23.
[3] CHEN Wangxing, ZHAO Xue, LIU Yan, LIU Yue, JIN Chunshun. Psychological status of patients with deviated nasal septum or chronic sinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 24-27.
[4] Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps. Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 28-31.
[5] LI Huabin, LAI Yuting. Pathogenesis, diagnosis, and treatment of chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 4-9.
[6] YU Qianqian, GUAN Ge, ZHANG Niankai, LI Na, WEN Junfeng, LIU Tingting, LIAN Yuanyuan. Characteristics of respiratory epithelial adenomatoid hamartomas in the nasal olfactory cleft on computed tomography [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 76-81.
[7] LI Hongmei, WANG Lan, GAO Zhaohui, WANG Ying, XUE Jinmei. The expression and significance of p-ERK2/ ERK2 in nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 42-46.
[8] ZHANG Jie, GONG Qi. Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 54-57.
[9] GAN Bin, ZHANG Yongju, XU Anting. BRF2 in the pathogenesis of chronic rhinosinusitis with nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 47-53.
[10] ZHI Lili, SONG Daoliang. Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 43-46.
[11] LUN Jie, ZHANG Ya′nan. Analysis on the factors related to the recurrence of chronic rhinosinusitis with nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 80-83.
[12] . The aqueous levels of TNF-α and IP-10 in different kinds of glaucoma and their correlation. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(1): 103-106.
[13] LIU Ye, SUN Dianshui, YIN Jinjun, XIA Ming, XU Ying, SUN Jianhua. Vestibular function damage mechanisms in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 14-17.
[14] WANG Haipeng, XU Huijuan, ZHANG Xiufang, WANG Huizhong, LI Yanzhong. The application of Sinus Jel in adult patients of nasal polyps with sleep-disordered breathing. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 58-60.
[15] SU Yi, XIE Jinghua, PAN Xiaoli, ZENG Guoqing. Efficacy and associated factors of endoscopic sinus surgery on patients with chronic rhinosinusitis with or without nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 86-89.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd