JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Correlation between nuclear factor-kappa B subunit P50 activity and IL-4 and γ-IFN expressions in nasal polyps

LI Yun-qiu1, FENG Yong2, WANG Ji-hua1   

  1. Department of Otolaryngology Head and Neck Surgery, 1. Hunan Provincial Hospital, Changsha 410002, China;2. Xiangya Hospital of Central South University, Changsha 410002, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-02-24 Published:2008-02-24
  • Contact: LI Yun-qiu

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Abstract: To explore the possible regulatory mechanism of nuclear factorkappa B subunit P50 to Th1/Th2 cytokine in nasal polyps. MethodsThe expressions of IL-4 , γ-IFN and P50 were determined by the method of immunohistochemistry staining in 40 cases of nasal polyps and 20 normal subjects, and the linear correlations between activities of P50 and IL-4 and γ-IFN were evaluated. ResultsThe expression of P50 was mainly distributed in the cytoplasm of epithelia, inflammatory cells and the epithelia of glands, and the expression of IL-4 and the activity of P50 were significantly increased in nasal polyps(both P<0.001), however, the expression of γ-IFN had no significant differences between the groups(P>0.05). The Pearson correlation analysis demonstrated that P50 nuclear-presence closely correlated with the IL-4 level, but not with γ-IFN. The correlation coefficient was 0.70 for P50 and IL-4(P<0.001 ) and 0.14 for P50 and γ-IFN (P>0.05). ConclusionThe activity of P50 in nasal polyps significantly increases, and it may play an important role in the imbalance of Th1/Th2-typed cytokines by up-regulating the level of IL-4.

Key words: Nuclear factor κB sub-unit P50, Cytokine, Nasal polyps, IL-4, γ-IFN

CLC Number: 

  • R765.25
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