JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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STAT3 expression in laryngeal carcinoma tissues and its relation with Survivin expression

ZHANG Han-bing1，ZHANG Dao-gong2，PAN Xin-liang1， LUAN Xin-yong1，XIE Guang1   

  1. Department of Otolaryngology & Head and Neck Surgery, 1. Qilu Hospital of Shandong University, Jinan 250012, China;2. Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-04-24 Published:2008-04-24
  • Contact: ZHANG Han-bing

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Abstract: To investigate the expression characters of signal transducer and activator of transcription 3(STAT3) and its relation with the expression of Survivin in laryngeal carcinoma. MethodsImmunohistochemistry (IHC) was used to determine the protein expressions of STAT3, p-STAT3 and Survivin in 40 laryngeal squamous cell carcinoma tissues and 12 normal control laryngeal mucous tissues. Also RT-PCR was used to determine the expressions of STAT3 mRNA and Survivin mRNA. ResultsThe expressions of STAT3, p-STAT3 and Survivin protein in laryngeal carcinoma tissues were significantly higher than those in normal laryngeal tissues (P＜0.01). And the expressions of STAT3 mRNA and Survivin mRNA were significantly higher in laryngeal carcinoma tissues than those in normal laryngeal tissues (P＜0.01). Positive expressions of STAT3, p-STAT3 protein and STAT3 mRNA were correlated with the clinical stage and had no relationship with patient age, tumor position, histological grade, and lymph node metastasis, and also positive expression of Survivin protein and Survivin mRNA was correlated with the clinical stage and lymph node metastasis. There were positive correlations between STAT3 and Survivin expression in laryngeal carcinoma. Conclusions Over-expression of STAT3 may play an important role in the genesis and growth of laryngeal carcinoma. STAT3 may prolong the survival time of laryngeal carcinoma by increasing the expression of Survivin.

Key words: Signal transducer and activator of transcription 3, Survivin, Laryngeal neoplasms, RT-PCR, Immunohistochemistry

CLC Number: 

  • R739.65
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