JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2011, Vol. 25 ›› Issue (2): 10-.

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Alzheimer-associated neuronal thread protein in urine and serum amyloid A protein in patients with obstructive sleep apnea syndrome

ZHU Feng-juan1， FAN Xian-liang2， FENG Hui-wei2， ZHANG Hui2， JIA Tao2， ZHANG Hong-ping2   

  1. 1. School of Medicine Shandong University, Jinan 250012, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, Second Hospital of Shandong University, Jinan 250033, China
  • Received:2010-12-08 Revised:2011-01-22 Online:2011-04-16 Published:2011-04-16

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Abstract:

Objective     To investigate the Alzheimer associated neuronal thread protein (AD7c-NTP) in urine and serum amyloid A protein (SAA) in patients with obstructive sleep apnea syndrome (OSAS). Methods     52 patients with OSAS were recruited as the experimental group, while eighteen healthy subjects with matched age and BMI were recruited as the control group. The AD7c-NTP and SAA specific monoclonal ELISA method was used to measure AD7c-NTP in morning urine and SAA in serum. In addition, correlations of AD7c-NTP and SAA between apnea hypopnea index (AHI) and the lowest arterial oxygen saturation (LSaO2) were analyzed. All data were processed in SPSS 17.0. Results    Compared with the control group, AD7c-NTP and SAA levels were significantly higher in the OSAS group（P＜0.05）. AD7c-NTP and SAA were positively correlated with AHI, but negatively correlated with LSaO2.  Conclusion     AD7c-NTP and SAA levels are significantly higher in OSAS patients and correlated with the degree of OSAS. Elevated AD7c-NTP and SAA level may contribute to some increased risks for SD (senile dementia) in OSAS patients.

Key words: Sleep apnea, obstructive; Alzheimer associated neuronal thread protein; Serum amyloid A protein; Senile dementia

CLC Number: 

  • R766.7
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