JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (2): 31-35.doi: 10.6040/j.issn.1673-3770.0.2014.352

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Expressions of EGF and EGFR in nasal polyps epithelium

DUAN Chen1, XU Xin2, SHI Li3   

  1. 1. School of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Qingdao Caretaker Otolaryngology Head & Neck Surgery Hospital, Qingdao 266071, Shandong, China;
    3. Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-11-05 Online:2015-04-16 Published:2015-04-16
  • Contact: 史丽。E-mail:shili126@sina.com E-mail:shili126@sina.com

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Abstract: Objective To investigate the expressions of epidermal growth factor (EGF) and epidermal growth factor receptor(EGFR) in nasal polyps (NPs) as well as their potential roles in polyp epithelium. Methods Polyp biopsies were collected from 25 patients with NPs. Inferior turbinates were obtained from 10 subjects with septal deviation, which were served as the control group. EGF and EGFR expression levels were assessed by using immunohistochemistry and real-time quantitative PCR. Results Staining results revealed that EGF and EGFR mainly localized in basal epithelial cells, and their protein levels were significantly lower in NP than in the control. Down-regulation of both EGF and EGFR mRNA levels were further confirmed in NP as compared with control samples. Conclusion Lower expression of EGF and EGFR in epithelium may be involved in the defect of epithelial repair process in NP.

Key words: Epidermal growth factor, Nasal polyps, Epithelial repair, Epidermal growth factor receptor

CLC Number: 

  • R765.4+1
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