JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (4): 94-97.doi: 10.6040/j.issn.1673-3770.0.2015.526

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Diagnostic value of plasma 1-3-β-D glucan for fungal rhinosinusitis.

YU Pengju1, XU Fenglei2, YANG Jun1, CHEN Wei3, JIANG Manjie   

  1. 1. Department of otorhinolaryngology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan 215300, Jiangsu, China;2. ENT &HN Surgery Department, The Second Hospital of Shandong University, Jinan 250000, Shandong, China;3. Department of Otolaryngology-Head Neck Surgery, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu, China
  • Received:2015-12-11 Online:2016-08-16 Published:2016-08-16

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Abstract: Objective To analyze the value of plasma 1-3-β-D glucan for diagnosis of fungal rhinosinusitis. Methods Patients with nasosinusitis underwent surgery treatment at our hospital from 2014 to 2015 were selected and divided into observation group(fungal rhinosinusitis)and control group(bacterial rhinosinusitis)according to the postoperative pathological diagnosis. Changes of 1-3-β-D glucan, C-reactive protein(CRP)and procalcitonin(PCT)in peripheral blood were compared. Results A total of 83 patients were enrolled, in which 41 cases were divided in observation group and 42 cases were divided in control group. Patients in observation group had a higher level of 1-3-β-D glucan than that of control group before surgery(P<0.05), but decreased significantly after surgery(P<0.05). Correlation analysis showed that, for patients in observation group, the levels of 1-3-β-D glucan had significant positive correlation with CRP(t=0.846, P=0.002)and PCT(t=0.701, P=0.002). ROC analysis showed that the 1-3-β-D glucan cut-off point value of 12.0 pg/mL, as used for the diagnosis of fungal rhinosinusitis, provided a sensitivity of 90.48%, a specificity of 95.12%, better than these of CRP and PCT. Conclusion Plasma 1-3-β-D glucan assay for diagnosis of fungal rhinosinusitis is reliable and it has potential to become a practical indicator for auxiliary preoperative diagnosis.

Key words: Diagnosis, C-reactive protein, 1-3-β-D glucan, Procalcitonin, Fungal rhinosinusitis

CLC Number: 

  • R765.4
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